Phytotherapy for breast cancer

Alugoju, Phaniendra; Chaitanya, Nyshadham S.N.; Krishnaswamy, V.K.D.; Kancharla, Pavan Kumar

doi:10.1016/b978-0-12-822009-2.00007-8

Cited by 7 publications

(3 citation statements)

References 192 publications

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“…The leaf extract has been proven to be effective against infections caused by E. coli, S. aureus, S. pyrogens, B. subtilis and P. vulgaris , as well as helping in cell repair and rejuvenation[ 171 ]. Plant phytochemicals such as alkaloids, terpenoids, lignans, and steroids contributed to the pharmacological activities; also, its chloroform fraction contains pharmacologically active substances like rutin and quercetin, which have anticancer activity in MDA-MB-231 and MCF 7 breast cancer cells[ 172 , 173 ]. In vitro and in vivo studies demonstrated that the alkaloid present in T. cordifolia contributes to the antihyperglycemic effect via insulin-releasing and insulin-mimicking pathways, hence reducing postprandial hyperglycemia[ 174 ].…”

Section: Discussionmentioning

confidence: 99%

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Narzary¹,

Swarnakar²,

Kalita³

et al. 2023

World J Clin Cases

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BACKGROUND Diabetic foot ulcer (DFU) is a serious health issue of diabetes mellitus that affects innumerable people worldwide. Management and treatment of this complication are challenging, especially for those whose immune system is weak. AIM To discuss the plants and their parts used to heal DFU, along with the mode of their administration in diabetic patients. METHODS The original articles on “the plants for the treatment of DFU” studied in clinical cases only were obtained from various bibliographic databases using different keywords. RESULTS The search resulted in 22 clinical cases records with 20 medicinal plants belonging to 17 families on 1553 subjects. The fruits and leaves were the most preferentially used parts for DFU treatment, regardless of whether they were being administered orally or applied topically. Of the 20 medicinal plants, 19 reported their effectiveness in increasing angiogenesis, epithelialization, and granulation, thus hastening the wound-healing process. The efficacy of these botanicals might be attributed to their major bioactive compounds, such as actinidin and ascorbic acid (in Actinidia deliciosa ), 7-O-(β-D-glucopyranosyl)-galactin (in Ageratina pichinchensis ), omega-3-fatty acid (in Linum usitatissimum ), isoquercetin (in Melilotus officinalis ), anthocyanins (in Myrtus communis ), and plantamajoside (in Plantago major ). CONCLUSION The validation of mechanisms of action underlying these phytocompounds contributing to the management of DFU can aid in our better understanding of creating efficient treatment options for DFU and its associated problems.

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Section: Discussionmentioning

confidence: 99%

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Narzary¹,

Swarnakar²,

Kalita³

et al. 2023

World J Clin Cases

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“…Li and colleagues (2020) discovered that andrographolide facilitates downregulation of the PI3K/Akt/mTOR pathway and inhibits glycolysis, a vital process that is needed for the survival and proliferation of cancer cells [ 75 ]. Andrographolide is also known to inhibit the PI3K/Akt/mTOR pathway and suppress angiogenic regulators such as vascular endothelial growth factor (VEGF) [ 76 ]. VEGF plays a major role in suppressing anti-cancer response in cells, which is facilitated by hypoxia-inducible factor (HIF)-1 [ 77 ].…”

Section: The Role Of Andrographis Paniculata In Li...mentioning

confidence: 99%

Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway

Naomi

Bahari

Ong

et al. 2022

IJMS

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Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of pharmacological activities, including anti-cancer properties, particularly in the lipid-dependent cancer pathway. Lipids act as crucial membrane-building elements, fuel for energy-demanding activities, signaling molecules, and regulators of several cellular functions. Studies have shown that alterations in lipid composition assist cancer cells in changing microenvironments. Thus, compounds that target the lipid pathway might serve as potential anti-cancer therapeutic agents. The purpose of this review is to provide an overview of the medicinal chemistry and pharmacology of A. paniculata and its active compounds in terms of anti-cancer activity, primary mechanism of action, and cellular targets, particularly in the lipid-dependent cancer pathway.

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“…Recent developments in drug discovery in cancer research have led to the identification and evaluation of a plethora of phytochemicals for their potent anti-cancer efficacy against different cancers. Indeed, more than 100 plant-derived compounds are currently being used as drugs in modern medicine, while many other drugs are simple synthetic modifications of natural phytochemicals [7,8]. Since ancient times, traditional medicinal plants have been used to treat various human ailments including cancer.…”

Section: Introductionmentioning

confidence: 99%

7-Geranyloxycinnamic Acid Isolated from Melicope lunu-ankenda Leaves Perturbs Colon Cancer and Breast Cancer Cell Lines’ Growth via Induction of Apoptotic Pathway

et al. 2023

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Globally, breast cancer is the most prevalent form of cancer in women and there is a need for alternative therapies such as plant-derived compounds with low systemic toxicity and selective toxicity to cancer cells. The aim of this study is to assess the cytotoxicity effects of 7-geranyloxycinnamic acid isolated from leaves of Melicope lunu-ankenda, a traditional medicinal plant, on the human breast cancer cell lines. Dried leaf powder was used for the preparation of different crude extracts using different solvents of increasing order of polarity. The structure of the isolated compound from the petroleum ether extract was elucidated by 1H and 13C NMR, LC-MS, and DIP−MS spectroscopy. The cytotoxic activity of the crude extract and 7-geranyloxycinnamic acid analyzed using MTT assay. Apoptotic analysis was evaluated using Annexin V-PI staining, AO/PI staining, intracellular ROS measurement, and measurement of activities of caspases 3/7, 8, and 9. Crude extracts and the isolated pure compound showed significant cytotoxicity against tested cancer cell lines. 7-geranyloxycinnamic acid was found to exert significant cytotoxic effects against breast cancer cell lines such as the MCF-7 and MDA-MB-231 cell lines. The cytotoxic effects are attributed to its ability to induce apoptosis via accumulation of ROS and activation of caspases in both breast cancer cell lines. The pure compound, 7-geranyloxycinnamic acid isolated from the leaves of M. lunu-ankenda, can exert significant cytotoxic effects against breast cancer cell lines without affecting the normal cells.

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Phytotherapy for breast cancer

Cited by 7 publications

References 192 publications

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway

7-Geranyloxycinnamic Acid Isolated from Melicope lunu-ankenda Leaves Perturbs Colon Cancer and Breast Cancer Cell Lines’ Growth via Induction of Apoptotic Pathway

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Phytotherapy for breast cancer

Cited by 7 publications

References 192 publications

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century: A systematic review

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century: A systematic review

Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway

7-Geranyloxycinnamic Acid Isolated from Melicope lunu-ankenda Leaves Perturbs Colon Cancer and Breast Cancer Cell Lines’ Growth via Induction of Apoptotic Pathway

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Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21^st century: A systematic review