Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway

Naomi, Ruth; Bahari, Hasnah; Ong, Zhi Yi; Yong, Yoke Keong; Embong, Hashim; Rajandram, Retnagowri; Teoh, Soo Huat; Othman, Fezah; Hasham, Rosnani; Khoo, Boon Yin; Kaniappan, Priyatharisni; Yazid, Muhammad Dain; Zakaria, Zainul Amiruddin

doi:10.3390/ijms23115972

Cited by 6 publications

(2 citation statements)

References 112 publications

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“…It does this by affecting the early proliferation and differentiation of the T cells. Additionally, it decreases cytokine expression and splenic cell counts and CD4+ IFN-γ + T cells within 4–7 weeks of undergoing treatment [ 126 , 127 ].…”

Section: Miscellaneous Natural Productsmentioning

confidence: 99%

Introduction to Traditional Medicine and Their Role in Prevention and Treatment of Emerging and Re-Emerging Diseases

et al. 2022

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Infectious diseases have been a threat to human health globally. The relentless efforts and research have enabled us to overcome most of the diseases through the use of antiviral and antibiotic agents discovered and employed. Unfortunately, the microorganisms have the capability to adapt and mutate over time and antibiotic and antiviral resistance ensues. There are many challenges in treating infections such as failure of the microorganisms to respond to the therapeutic agents, which has led to more chronic infections, complications, and preventable loss of life. Thus, a multidisciplinary approach and collaboration is warranted to create more potent, effective, and versatile therapies to prevent and eradicate the old and newly emerging diseases. In the recent past, natural medicine has proven its effectiveness against various illnesses. Most of the pharmaceutical agents currently used can trace their origin to the natural products in one way, shape, or form. The full potential of natural products is yet to be realized, as numerous natural resources have not been explored and analyzed. This merits continuous support in research and analysis of ancient treatment systems to explore their full potential and employ them as an alternative or principal therapy.

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Section: Miscellaneous Natural Productsmentioning

confidence: 99%

Introduction to Traditional Medicine and Their Role in Prevention and Treatment of Emerging and Re-Emerging Diseases

et al. 2022

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“…In HT-29 cancer cell line, it allows apoptosis and inhibits the cell cycle that depends on its doses [8]. The andrographolide compound has activity as an anticancer through inhibition of NF-kb and multiple lipid-dependent pathways in the lungs, ovary, and breast cancer [9,10]. In addition, T. crispa L. stems contain tinocropside, columbine, berberine, apigenin, and pycroretoside glycoside for allowing apoptosis, decreasing blood glucose levels, and NF-Kb gene expression in breast cancer cells [11,12].…”

Section: Introductionmentioning

confidence: 99%

Protein-Protein Interaction Analysis to Identify Nuclear Factor-Erythroid-2 Factor 2 (Nrf2) Inhibition by Extracellular Enzymes From Water Kefir Organisms

ZUHROTUN,

PRIJADI,

INDRADI

et al. 2023

Int J App Pharm

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Objective: This research was conducted to screen the anticancer activity of bitter herbs that contains Andrographis paniculata (Brum. f) leaves (AP) and Tinospora crispa L. stems (TC) in form of fresh materials and extracts using a mechanism-based yeast bioassay. Methods: Samples tested by mechanism-based yeast bioassay (MBYB) were single extract, mixed extract, and jamu gendong pahitan from a traditional market and made in the laboratory. Fresh sample of jamu gendong pahitan from the market and a single extract (AP and TC) was tested at one dose. While fresh jamu gendong pahitan made in the laboratory and the mixed extract (AP: TC) was tested at three different doses, doses 1 (3:10), dose 2 (1:1), and dose 3 (10:3). The leaves and stems were extracted by 70% ethanol for 3x24 h, each day the solvent was changed then every macerate was evaporated using a rotavapor and water bath. By this MBYB method, noted that the active sample must have an IC12 value of<8000µg/ml, so all the samples or doses were tested using final concentration varying at around 8,000; 4,000; 2,000; 1,000; 500, 250, and 125µg/ml. Results: The percentage yield of Andrographis paniculata (Brum. f) leaves was 11.2% and Tinospora crispa L. stems was 19.%. The activity assay for jamu gendong pahitan from the traditional market was inactive as a topoisomerase inhibitor (IC12>8000µg/ml). Samples showed topoisomerase I inhibitor activity were jamu gendong pahitan made in laboratory doses 1 and 2. While samples showed topoisomerase I and II inhibitor activities were jamu gendong pahitan made in laboratory dose 3, single and mixed extracts. Conclusion: The fresh material of jamu gendong pahitan (bitter herbs) bought from the market is inactive, while the fresh material of samples of jamu gendong pahitan made in laboratory doses 1 and 2 have topoisomerase I inhibitor activity. Based on the IC12, value, it is known that the sample that gave the best activity was the mixed extract of bitter herbs dose 3 that contain extract of A. paniculata and T. crispa (10:3), with IC12 values in strains 1138, 1140, and 1353 were 926.28±173, 576.75±42, and 865.5±135µg/ml respectively.

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Assessment of multi-biomedical efficiency of Andrographis paniculata shoot extracts through in-vitro analysis and major compound identification

Chau,

Samdani,

Kuriakose

et al. 2024

Environmental Research

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Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway

Cited by 6 publications

References 112 publications

Introduction to Traditional Medicine and Their Role in Prevention and Treatment of Emerging and Re-Emerging Diseases

Introduction to Traditional Medicine and Their Role in Prevention and Treatment of Emerging and Re-Emerging Diseases

Protein-Protein Interaction Analysis to Identify Nuclear Factor-Erythroid-2 Factor 2 (Nrf2) Inhibition by Extracellular Enzymes From Water Kefir Organisms

Assessment of multi-biomedical efficiency of Andrographis paniculata shoot extracts through in-vitro analysis and major compound identification

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