Phytotherapie - Behandlung ohne Nebenwirkungen?

Saller, Reinhard; Reichling, Jürgen; Kristof, O.

doi:10.1055/s-2007-1023899

Cited by 11 publications

(3 citation statements)

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“…In total, 14 documents were selected, which provided detailed information about the medical uses of 102 taxa that were uninterruptedly used for therapeutic purposes through all time periods. We omitted herbals which did not add new uses [36][37][38][39][40] or did not provide detailed information about the medical use of single species (index of Capitulare de villis [41] and index of Lonicero [42]).…”

Section: Written Sourcesmentioning

confidence: 99%

Trends of Medicinal Plant Use over the Last 2000 Years in Central Europe

Cero

Saller²,

Leonti

et al. 2022

Plants

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Medicinal plant knowledge in Central Europe can be traced back from the present to antiquity, through written sources. Approximately 100 medicinal plant taxa have a history of continuous use. In this paper, we focus on use patterns over time and the link between historical and traditional uses with the current scientific evidence. We discuss our findings against the backdrop of changing eras and medicinal concepts. Based on use-records from totally 16 historical, popular and scientific herbals, we analyze how use categories of 102 medicinal plant taxa developed over time. Overall, 56 of the 102 taxa maintained continuous use throughout all time periods. For approximately 30% of the continuous uses, scientific evidence supporting their use exists, compared to 11% for recently added uses and 6% for discontinuous uses. Dermatology and gastroenterology are use categories that are relevant across all time periods. They are associated with a high diversity of medicinal taxa and continuously used medicinal species with scientific evidence. Antidotes, apotropaic (protective) magic, and humoral detoxification were important use categories in the past. New applications reflecting biomedical progress and epidemiological challenges are cardiovascular and tonic uses. Changes in medicinal concepts are mirrored in plant use and specifically in changes in the importance of use categories. Our finding supports the concept of social validation of plant uses, i.e., the assumption that longstanding use practice and tradition may suggest efficacy and safety.

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Section: Written Sourcesmentioning

confidence: 99%

Trends of Medicinal Plant Use over the Last 2000 Years in Central Europe

Cero

Saller²,

Leonti

et al. 2022

Plants

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“…However, like synthetic drugs, the cytotoxicity and mechanism of plant-derived remedies should also be evaluated to assess their clinical efficacy, quality and safety [18][19][20] as well as undesired side effects [17,21] . In this study, we assessed the cytotoxic effects of GA on nontumorigenic MC-3T3-E1 cells (a mouse calvaria osteoblast cell line).…”

Section: Introductionmentioning

confidence: 99%

Antitumor Effects of Ginkgolic Acid in Human Cancer Cell Occur via Cell Cycle Arrest and Decrease the Bcl-2/Bax Ratio to Induce Apoptosis

Zhou¹,

Li²,

Du³

et al. 2010

Chemotherapy

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Background: Ginkgolic acids (GAs), extracted from the seed coat of Ginkgo biloba L. Our previous study has shown that GA monomer could inhibit the growth of Hep-2 significantly and induce the fragmentation of the chromosomal DNA. To further assess the antitumor potential and turn it into a candidate new antitumor drug, the antitumor mechanism of GA was investigated. Method: The cytotoxicity and antitumor effect of GA monomer were assayed by MTT colorimetric assay with nontumorogenic MC-3T3-E1 as well as tumorogenic Hep-2 and Tac8113 cell lines. The effect of GA monomer on the proliferation of tumor cell lines was analyzed with MTT colorimetric and CFSE labeled assay. Cell cycle distribution and measurement of the percentage of apoptotic cells were performed by flow cytometry following stained with propidium iodide, annexin V-FITC. The expression of apoptotic proteins Bcl-2, Bax and caspase-3 was analyzed with Western blot. Result: GA only inhibited the growth of tumorogenic cell lines in a both dose- and time-dependent manner. Tumor cells were treated with GA for 72 h, 70.53 ± 4.54% Hep-2 and 63.5 ± 7.2% Tca8113 cells were retarded at GO/G1 phase, and the percentage of apoptosis was 40.4 ± 1.58 and 38.4 ± 1.7%, respectively. GA-treated activated caspase-3 downregulated the expression of anti-apoptotic Bcl-2 protein and upregulated the expression of pro-apoptotic Bax protein, eventually leading to a decrease in the Bcl-2/Bax ratio in tumor cells. Conclusions: The antitumor action of GA was due to inhibiting the proliferation in a manner of inhibiting division, retarding the progress of cell cycle and inducing apoptosis, making GA a candidate as new antitumor drug.

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“…podem conter constituintes que exercem efeitos colaterais indesejáveis (Shaw et al, 1997). Assim, os fitoterápicos devem ser avaliados sob diversos aspectos, tais como eficácia, qualidade e segurança (Couzinier & Mamatas, 1986;Saller et al, 1998;De Smet, 1995).…”

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