Phytosterols as the core or stabilizing agent in different nanocarriers

Mohammadi, Maryam; Jafari, Seid Mahdi; Hamishehkar, Hamed; Ghanbarzadeh, Babak

doi:10.1016/j.tifs.2020.05.004

Cited by 50 publications

(33 citation statements)

References 124 publications

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“…Liposomes have an enclosed vesicular structure and are able to accommodate both water-soluble and hydrophobic compounds in their internal aqueous core and bilayer space, respectively [ 6 ]. Moreover, the typical constituents of liposomes are completely natural, and their nontoxicity has led to the broad application of these vesicular systems in the encapsulation of various bioactive compounds [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Engineering of Liposome Structure to Enhance Physicochemical Properties of Spirulina plantensis Protein Hydrolysate: Stability during Spray-Drying

et al. 2021

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Encapsulating hydrolysates in liposomes can be an effective way to improve their stability and bioactivity. In this study, Spirulina hydrolysate was successfully encapsulated into nanoliposomes composed of different stabilizers (cholesterol or γ-oryzanol), and the synthesized liposomes were finally coated with chitosan biopolymer. The synthesized formulations were fully characterized and their antioxidant activity evaluated using different methods. Then, stabilization of coated nanoliposomes (chitosomes) by spray-drying within the maltodextrin matrix was investigated. A small mean diameter and homogeneous size distribution with high encapsulation efficiency were found in all the formulations, while liposomes stabilized with γ-oryzanol and coated with chitosan showed the highest physical stability over time and preserved approximately 90% of their initial antioxidant capacity. Spray-dried powder could preserve all characteristics of peptide-loaded chitosomes. Thus, spray-dried hydrolysate-containing chitosomes could be considered as a functional food ingredient for the human diet.

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Section: Introductionmentioning

confidence: 99%

Engineering of Liposome Structure to Enhance Physicochemical Properties of Spirulina plantensis Protein Hydrolysate: Stability during Spray-Drying

et al. 2021

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“…Because the consumed phytosterols would have limited intestinal absorption and crossing the BBB may take longer periods of ~6 weeks, higher doses may be required to capture the benefits [122]. Researchers have resorted to nanoencapsulation for improving the bioavailability of phytosterols in the food industry [123][124][125], but only for research purposes as a methodology of drug delivery. Thus, future studies should be carried out to explore the therapeutic and disease-specific mechanisms of phytosterols for their neuroprotective role in neurodegenerative diseases.…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases

Sharma

Tan

2021

IJMS

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Phytosterols constitute a class of natural products that are an important component of diet and have vast applications in foods, cosmetics, and herbal medicines. With many and diverse isolated structures in nature, they exhibit a broad range of biological and pharmacological activities. Among over 200 types of phytosterols, stigmasterol and β-sitosterol were ubiquitous in many plant species, exhibiting important aspects of activities related to neurodegenerative diseases. Hence, this mini-review presented an overview of the reported studies on selected phytosterols related to neurodegenerative diseases. It covered the major phytosterols based on biosynthetic considerations, including other phytosterols with significant in vitro and in vivo biological activities.

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“…Their study showed that the inclusion complex enhanced water solubility of sterols to 8.68 mg mL −1 and resulted in free form 0.02 mg mL −1 [ 78 ]. Likewise, many studies have recently been conducted to enhance the bioavailability of sterols, but no studies have focused on brain delivery [ 79 , 80 , 81 , 82 ]. Sterol-loaded nanocarriers seem promising to increase more bioavailability in blood; however, more extensive studies are required to investigate tissue and organ distributions and the toxicity risks.…”

Section: Technological Advances Toward Sterol Therapymentioning

confidence: 99%

Prospects of Marine Sterols against Pathobiology of Alzheimer’s Disease: Pharmacological Insights and Technological Advances

et al. 2021

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Alzheimer’s disease (AD) is a degenerative brain disorder characterized by a progressive decline in memory and cognition, mostly affecting the elderly. Numerous functional bioactives have been reported in marine organisms, and anti-Alzheimer’s agents derived from marine resources have gained attention as a promising approach to treat AD pathogenesis. Marine sterols have been investigated for several health benefits, including anti-cancer, anti-obesity, anti-diabetes, anti-aging, and anti-Alzheimer’s activities, owing to their anti-inflammatory and antioxidant properties. Marine sterols interact with various proteins and enzymes participating via diverse cellular systems such as apoptosis, the antioxidant defense system, immune response, and cholesterol homeostasis. Here, we briefly overview the potential of marine sterols against the pathology of AD and provide an insight into their pharmacological mechanisms. We also highlight technological advances that may lead to the potential application of marine sterols in the prevention and therapy of AD.

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Phytosterols as the core or stabilizing agent in different nanocarriers

Cited by 50 publications

References 124 publications

Engineering of Liposome Structure to Enhance Physicochemical Properties of Spirulina plantensis Protein Hydrolysate: Stability during Spray-Drying

Engineering of Liposome Structure to Enhance Physicochemical Properties of Spirulina plantensis Protein Hydrolysate: Stability during Spray-Drying

Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases

Prospects of Marine Sterols against Pathobiology of Alzheimer’s Disease: Pharmacological Insights and Technological Advances

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