Phytosterols and risk of lung cancer: A case-control study in Uruguay

Mendilaharsu, Marı́a; Stéfani, Eduardo De; Deneo‐Pellegrini, Hugo; Carzoglio, Julio; Ronco, Álvaro L.

doi:10.1016/s0169-5002(98)00044-0

Cited by 80 publications

(50 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mendilaharsu et al (1998) carried out a case-control study with 463 subjects with newly diagnosed primary lung cancer and 465 hospitalized controls in Uruguay to determine the effect of phytosterol intake on lung carcinogenesis within 3 years. Phytosterol consumption was associated with reduced risk of the cancer by approximately 50%, after correcting for factors including tobacco smoking, vegetables, fruits and antioxidant substances, known to be confounders.…”

Section: Effect Of Phytosterol Intake On Cancer Development In Humansmentioning

confidence: 99%

“…In addition to their cholesterol-lowering actions, mounting evidence suggests that phytosterols possess anti-cancer effects against cancer of the lung (Mendilaharsu et al, 1998), stomach (De Stefani et al, 2000), ovary (McCann et al, 2003) and estrogen-dependent human breast cancer (Ju et al, 2004). It has been speculated that phytosterols inhibit the production of carcinogens, cancer-cell growth, invasion and metastasis, and promote apoptosis of cancerous cells (Meric et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anticancer effects of phytosterols

2009

View full text Add to dashboard Cite

Phytosterol and stanol (or phytosterols) consumption reduces intestinal cholesterol absorption, leading to decreased blood LDL-cholesterol levels and lowered cardiovascular disease risk. However, other biological roles for plant sterols and stanols have also been proposed. The objective of this review is to critically examine results from recent research regarding the potential effects and mechanisms of action of phytosterols on forms of cancer. Considerable emerging evidence supports the inhibitory actions of phytosterols on lung, stomach, as well as ovarian and breast cancer. Phytosterols seem to act through multiple mechanisms of action, including inhibition of carcinogen production, cancer-cell growth, angiogenesis, invasion and metastasis, and through the promotion of apoptosis of cancerous cells. Phytosterol consumption may also increase the activity of antioxidant enzymes and thereby reduce oxidative stress. In addition to altering cell-membrane structure and function, phytosterols probably promote apoptosis by lowering blood cholesterol levels. Moreover, consumption of phytosterols by healthy humans at the recommended level of 2 g per day does not cause any major health risks. In summary, mounting evidence supports a role for phytosterols in protecting against cancer development. Hence, phytosterols could be incorporated in diet not only to lower the cardiovascular disease risk, but also to potentially prevent cancer development.

show abstract

Section: Effect Of Phytosterol Intake On Cancer Development In Humansmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anticancer effects of phytosterols

2009

View full text Add to dashboard Cite

show abstract

“…Des travaux scientifiques ont prouvé que les phytostérols pouvaient réduire le risque de certains types de cancers notamment celui du poumon [13], du sein [14], oesophage [15], de l'estomac [16] …”

Section: Matériel Et Méthodesunclassified

Etude des phytostérols et des acides gras de pistachia atlantica

Ghalem¹,

Benhassaini²

2011

Afrique Science: Revue Internationale Des Sciences Et Technologie

View full text Add to dashboard Cite

“…While M. paniculata came in the second rank and give ICR 50R 65.1 μg/ml (A549 cells) with inhibition 77.3% at 100µg/ml. In these regards, Choi et al [44] and Lopes et al [45] found that phytosterols have anti-cancer effects, against stomach cancer [46], lung cancer [47], ovary [48] and breast cancer [49] by enhancing stimulation of X-receptor and switch of sphingomyelin, suppression of cell division and induce apoptosis by activation of caspase [50]. It has been speculated that phytosterols inhibit cancer-cell growth, metastasis, invasion, and induce apoptosis [51].…”

Section: Anti-tumor Activitymentioning

confidence: 99%

Sterols Bioactivity of Ruta Graveolens L. And Murraya Paniculata L.

Baker

Ibrahim

Kandeil

et al. 2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: Ruta graveolens L. (R. graveolens) and Murraya paniculata L. (M. paniculata) are medicinal plants belonging to Rutaceae family have many uses in traditional medicine. The aim of the present study was to investigate sterols bioactivity of the two Rutaceae plant leaves.Methods: Sterols of the two Rutaceae plant leaves were identified using GC/MS. The antioxidant activities of the sterols of these herbs were evaluated by three different methods; free radical scavenging using 2,2′-Azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), 1,1-Diphenyl-2-picryl-hydrazyl ( Results: GC/MS assay showed β-Sitosterol (36%) as the most abundant sterols of R. graveolens followed by stigmasterol (18%), while stigmasterol (25.2%) was the most abundant one of M. paniculata steroids. The anti-inflammatory potential of R. graveolens steroids was significantly higher than that of diclofenac sodium (standard drug). M. paniculata sterols have higher antiviral activity (IC DPPH) and total antioxidant activity. The anticancer activity of the sterols was determined by MTT assay against colorectal cancer HCT116, breast cancer MCF7, liver cancer HepG2 and lung cancer A549 cell lines. Anti-inflammatory activity was evaluated using albumin denaturation assay and antiviral activities against H5N1 virus were carried out using plaque reduction assay. 50= 0.15 of µg/ml) than R. graveolens sterols (IC50 Conclusion:The current study suggests that the sterols of M. paniculata have more anti-viral activity than R. graveolens sterols which showed more anticancer and anti-inflammatory activities. = 7.8 of µg/ml). The sterols of R. graveolens showed anticancer activity against MCF7 and A549 cells with inhibition 84.3 and 81%, at 100 µg/ml respectively. While M. paniculata sterols showed 77.3% inhibition against A549 cells.

show abstract

Phytosterols and risk of lung cancer: A case-control study in Uruguay

Cited by 80 publications

References 19 publications

Anticancer effects of phytosterols

Anticancer effects of phytosterols

Etude des phytostérols et des acides gras de pistachia atlantica

Sterols Bioactivity of Ruta Graveolens L. And Murraya Paniculata L.

Contact Info

Product

Resources

About