Phytosomes:A Brief overview

Dhir, Sarika; Khar, Roop K.; Chakraborthy, G. S.; Saurabh, Maan

doi:10.18579/jpcrkc/2016/15/2/94471

Cited by 9 publications

(3 citation statements)

References 15 publications

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“…Virosomes are prepared by enveloped viruses such as influenza, herpes simplex, human immunodeficiency, rubella, yellow fever, etc., and these are derived from influenza containing constituents from the influenza virus envelope, hemagglutinin (HA), and neuraminidase (NA) that are incorporated into the phospholipids bilayers. HA and NA act as a carrier and adjuvant, and moreover, HA also responsible for rapid cellular uptake by endocytosis 40,41 .…”

Section: Fig 5: Structure Of Exosomesmentioning

confidence: 99%

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2021

IJPSR

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Section: Fig 5: Structure Of Exosomesmentioning

confidence: 99%

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2021

IJPSR

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“…Several studies were performed on the application of phytosome delivery systems for the various herbal products, including quercetin, 24 curcumin, 25 naringenin, 26 silybin, green tea, and ginkgo biloba 27–29 . Early research indicated that phytosome‐containing silymarin significantly enhanced the bioavailability and stability in the gastric media compared to other vesicular systems 30 .…”

Section: Introductionmentioning

confidence: 99%

“…22,23 Several studies were performed on the application of phytosome delivery systems for the various herbal products, including quercetin ,24 curcumin, 25 naringenin, 26 silybin, green tea, and ginkgo biloba. [27][28][29] Early research indicated that phytosome-containing silymarin significantly enhanced the bioavailability and stability in the gastric media compared to other vesicular systems. 30 Gabetta et al demonstrated that the pharmacological activity of flavanolignane-phospholipid complexes (1:1 of silybin, silidianin, and silicristin) was more apparent and noticeable compared to the pure flavanolignanes.…”

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Nanophytosomes of hesperidin and of hesperetin: Preparation, characterization, and in vivo evaluation

Omidfar

Gheybi

Davoodi

et al. 2022

Biotech and App Biochem

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Hesperidin and hesperetin are two important plant flavanones abundantly found in citrus fruit. They have discovered many biological activities to treat diseases, including cancer, diabetes, and Alzheimer's disease. Despite their various benefits, they have poor solubility, which reduces their bioavailability and absorption. In this study, nanophytosomes have been utilized to improve their payload's solubility and bioavailability. In the current study, hesperetin or hesperidin was complexed with Phospholipon 90G with a 2:1 or 3:1 molar ratio, respectively. The formation of associations between active compounds and phospholipid were confirmed by X‐ray diffraction (XRD), Fourier‐transform infrared spectroscopy (FTIR), and nuclear magnetic resonance (NMR) techniques. Dynamic light scattering data show that the prepared associations in the presence of body fluids can make nanoparticles in the range of 200–250 nm. In addition, oral administration demonstrated that Cmax of hesperidin and hesperetin was increased (up to four times) after complexation with the lipid. It is concluded that phospholipid association may be used as a suitable and straightforward strategy to improve therapeutic activities of hesperidin and hesperetin by increasing their solubility and bioavailability.

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