Phytosomes as Emerging Nanotechnology for Herbal Drug Delivery

Kumar, Dinesh; Vats, Nitin; Saroha, Kamal; Rana, Avtar Chand

doi:10.1007/978-3-030-41838-0_7

Cited by 13 publications

(7 citation statements)

References 60 publications

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“…Phospholipids have the property of an active emulsifier because of their hydrophilic head and lipophilic tail. The emulsifier property of phytosomes improves phytopolyphenol's bioavailability by facilitating them to pass from the aqueous to the lipophilic environment of the cell membrane [31]. Researchers have reported improved hepatoprotective and antioxidant effects of silybin phytosomes formulation in comparison to silybin alone [32].…”

Section: Phytosomesmentioning

confidence: 99%

Nanodelivery of Dietary Polyphenols for Therapeutic Applications

Rudrapal¹,

Mishra

Rani

et al. 2022

Molecules

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Advancement in nanotechnology has unleashed the therapeutic potentials of dietary polyphenols by enhancing bioavailability, improving biological half-life, and allowing site-specific drug delivery. In this review, through citation of relevant literature reports, we discuss the application of nano-pharmaceutical formulations, such as solid lipid nanoparticles, nano-emulsions, nano-crystals, nano-polymersomes, liposomes, ethosomes, phytosomes, and invasomes for dietary polyphenols. Following this, we highlight important studies concerning different combinations of nano formulations with dietary polyphenols (also known as nanophytopolyphenols). We also provide nano-formulation paradigms for enhancing the physicochemical properties of dietary polyphenols. Finally, we highlight the latest patents that were granted on nano-formulations of dietary polyphenols. Based on our review, we observe that nanosized delivery of herbal constituents, spices, and dietary supplements have the ability to improve biological processes and address issues connected with herbal treatments.

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Section: Phytosomesmentioning

confidence: 99%

Nanodelivery of Dietary Polyphenols for Therapeutic Applications

Rudrapal¹,

Mishra

Rani

et al. 2022

Molecules

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“…Another major advantage of phytosomes is their ability to improve the oral absorption of polar phytoactive compounds, leading to better bioavailability and greater therapeutic effects 20 . This is due to the ability of the phospholipid molecules in the phytosome to form chemical links with the phytoactive compounds, increasing their stability and solubility in aqueous solutions.…”

Section: Advantages Of Phytosomesmentioning

confidence: 99%

Phytosomes: A Promising Nanocarrier for Enhanced Delivery of Herbal Compounds in Cancer Therapy

Saeed,

Sadr,

Gharib

et al. 2022

J Lab Anim. Res

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Cancer is a life-threatening disease that remains a global health problem, with millions of people diagnosed yearly. Despite significant progress in cancer treatment, conventional chemotherapy still faces several limitations, including poor solubility, low bioavailability, lack of selectivity, and severe side effects. Therefore, alternative therapeutic strategies are necessary to improve cancer therapy. This review aimed to provide an updated overview of phytosome complexes and their potential application in cancer therapy, including their formulation techniques, transportation mechanism through phytosome, and recent investigations on their efficacy in treating different types of cancers. In recent years, nanotechnology has emerged as a promising approach to cancer therapy, as it enables the delivery of therapeutic agents to the tumor site with higher selectivity and efficiency. Phytosomes are a nanotechnology-based drug delivery system conjugating plant extracts or phytoconstituents with phospholipids. This conjugation results in the formation of a complex with improved solubility, stability, and bioavailability. Phytosomes have been shown to enhance the pharmacokinetic profile of phytoactive compounds, allowing for better targeting and sustained release. Phytosomes of curcumin, resveratrol, and quercetin have demonstrated anticancer properties in various in vitro and in vivo models. Moreover, phytosomes have been used to deliver chemotherapeutic agents, such as paclitaxel, docetaxel, and camptothecin, with improved efficacy and reduced toxicity. Phytosome complexes offer a promising platform for cancer therapy due to their ability to enhance the bioavailability and efficacy of phytoactive compounds. Incorporating phytosomes in cancer therapy could lead to the development of more effective and less toxic treatments for different types of cancers. Further studies are needed to elucidate the mechanism of action of phytosomes and to optimize their formulation for clinical use.

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“…Phytosomes are an innovative lipid-based delivery system that have a liposomes-related structure and can be used for the entrapment of different types of polyphenolic-based phytoconstituents to improve their absorption when administrated [ 63 , 64 , 65 ]. The first phytosomes were developed by Indena company (Milan, Italy) in the late 1980s, which aimed to increase the bioavailability of drugs by complexing them to phospholipids.…”

Section: Phytosomesmentioning

confidence: 99%

“…In recent years, there have been significant developments of novel nanosized delivery systems that may enhance the absorption and penetration of herbal bioactive materials through biological membranes, and therefore increase their bioavailability [ 62 ]. One of these emerging nanotechnologies that can be implemented to overcome the poor bioavailability of bioactive phytoconstituents and enhance their miscibility in lipid-rich barriers is phytosomes [ 63 ].…”

Section: Introductionmentioning

confidence: 99%

Phytosomes as an Emerging Nanotechnology Platform for the Topical Delivery of Bioactive Phytochemicals

et al. 2021

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The emergence of phytosome nanotechnology has a potential impact in the field of drug delivery and could revolutionize the current state of topical bioactive phytochemicals delivery. The main challenge facing the translation of the therapeutic activity of phytochemicals to a clinical setting is the extremely low absorption rate and poor penetration across biological barriers (i.e., the skin). Phytosomes as lipid-based nanocarriers play a crucial function in the enhancement of pharmacokinetic and pharmacodynamic properties of herbal-originated polyphenolic compounds, and make this nanotechnology a promising tool for the development of new topical formulations. The implementation of this nanosized delivery system could enhance the penetration of phytochemicals across biological barriers due to their unique physiochemical characteristics, improving their bioavailability. In this review, we provide an outlook on the current knowledge of the biological barriers of phytoconstituents topical applications. The great potential of the emerging nanotechnology in the delivery of bioactive phytochemicals is reviewed, with particular focus on phytosomes as an innovative lipid-based nanocarrier. Additionally, we compared phytosomes with liposomes as the gold standard of lipid-based nanocarriers for the topical delivery of phytochemicals. Finally, the advantages of phytosomes in topical applications are discussed.

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Phytosomes as Emerging Nanotechnology for Herbal Drug Delivery

Cited by 13 publications

References 60 publications

Nanodelivery of Dietary Polyphenols for Therapeutic Applications

Nanodelivery of Dietary Polyphenols for Therapeutic Applications

Phytosomes: A Promising Nanocarrier for Enhanced Delivery of Herbal Compounds in Cancer Therapy

Phytosomes as an Emerging Nanotechnology Platform for the Topical Delivery of Bioactive Phytochemicals

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