Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies

Mirzaei, Hamed; Shakeri, Abolfazl; Rashidi, Bahman; Jalili, Amin; Banikazemi, Zarrin; Sahebkar, Amirhossein

doi:10.1016/j.biopha.2016.11.098

Cited by 414 publications

(307 citation statements)

References 105 publications

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“…CUR is a polyphenol with both antioxidant and hydrophobic properties (Priyadarsini, 2013; Mirzaei et al, 2017), which may explain why it preferentially adsorbs to PMMA and the cell wall of C. albicans . We hypothesized that the hydrophobic nature of the molecule could drive the coated C. albicans cells to aggregate with one another, and if we consider this within the context oral delivery within saliva then there is the possibility of creating complexes of cells that minimize their interaction with the denture surface.…”

Section: Discussionmentioning

confidence: 99%

The Anti-Adhesive Effect of Curcumin on Candida albicans Biofilms on Denture Materials

et al. 2017

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The use of natural compounds as an alternative source of antimicrobials has become a necessity given the growing concern over global antimicrobial resistance. Polyphenols, found in various edible plants, offers one potential solution to this. We aimed to investigate the possibility of using curcumin within the context of oral health as a way of inhibiting and preventing the harmful development of Candida albicans biofilms. We undertook a series of adsorption experiments with varying concentrations of curcumin, showing that 50 μg/ml could prevent adhesion. This effect could be further synergized by the curcumin pre-treatment of yeast cells to obtain significantly greater inhibition (>90%, p < 0.001). Investigation of the biological impact of curcumin showed that it preferentially affected immature morphological forms (yeast and germlings), and actively promoted aggregation of the cells. Transcriptional analyses showed that key adhesins were down-regulated (ALS1 and ALS3), whereas aggregation related genes (ALS5 and AAF1) were up-regulated. Collectively, these data demonstrated that curcumin elicits anti-adhesive effects and that induces transcription of genes integrally involved in the processes related to biofilm formation. Curcumin and associated polyphenols therefore have the capacity to be developed for use in oral healthcare to augment existing preventative strategies for candidal biofilms on the denture surface.

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Section: Discussionmentioning

confidence: 99%

The Anti-Adhesive Effect of Curcumin on Candida albicans Biofilms on Denture Materials

et al. 2017

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“…Moreover, curcumin could induce apoptosis in cancer cell line, regulation of cell cycle, and increase of chemotherapy sensitivity (Zhou et al, ). However, some studies indicated that curcumin are associated with some limitations such as low oral absorption, bio‐distribution, and systemic bioavailability which lead to does not approved it as a drug in clinical (Mirzaei, Shakeri, et al, ). To date, several studies applied various curcumin analogs and novel drug delivery systems and can to overcoming to the current limitations (Mirzaei, Shakeri, et al, ; Momtazi et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that dietary factors such as curcumin have suitable anti‐cancer properties (Mirzaei, Khoi, Azizi, & Goodarzi, ). These agents exert their effects via a sequence of cellular and molecular pathways such as STAT3, MAPK, PTEN, and miRNA network (Mirzaei, Shakeri, et al, ). The utilization of these agents is associated with various advantages such as their non‐toxic properties.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA: A novel target of curcumin in cancer therapy

Mirzaei

Masoudifar

Sahebkar

et al. 2017

Journal Cellular Physiology

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Curcumin is known as a natural dietary polyphenol which is extracted from Curcuma longa L. It has been shown that curcumin has a variety of pharmacological effects such as antioxidant, anti-cancer, anti-inflammatory, and anti-microbial activities. Anti-cancer effects of curcumin are due to targeting of a wide range of cellular and molecular pathways involved in cancer pathogenesis including NF-kB, MAPK, PTEN, P53, and microRNAs (miRNA) network. Multiple lines of evidence have indicated that curcumin exerts its therapeutic effects via regulating miRNA expression (e.g., miR-1, miR-7, miR-9, miR-34a, miR-181, miR-21, and miR-19) which could lead to the regulation of underlying cellular and molecular pathways involved in cancer pathogenesis. Exosomes are one of the important classes of biological vehicles which could be released from various types of cells such as cancer cells and stem cells and could change the behavior of recipient cells. It has been shown that treatment of cancer cells with different dose of curcumin leads to the release of exosomes containing curcumin. These exosomes could induce anti-cancer properties in recipient cells and reduce tumor growth. Hence, exosomes containing curcumin could be applied as powerful tools for cancer treatment. Here, we highlighted various miRNAs which could be affected by curcumin in various types of cancer. Moreover, we highlight exosomes containing curcumin as suitable therapeutic tools in cancer therapy.

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“…[2][3][4] Importantly, oral administration of CM 12 g/day exhibited little toxicity in clinical trials. 5 However, clinical applications of insoluble CM face more challenging issues, such as low dissolution rate, low bioavailability, and controlled delivery.…”

Section: Introductionmentioning

confidence: 99%

Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

Xie¹,

Fan²,

Li³

et al. 2017

IJN

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Purpose To deliver insoluble natural compounds into colon cancer cells in a controlled fashion. Materials and methods Curcumin (CM)–silk fibroin (SF) nanoparticles (NPs) were prepared by solution-enhanced dispersion by supercritical CO 2 (SEDS) (20 MPa pressure, 1:2 CM:SF ratio, 1% concentration), and their physicochemical properties, intracellular uptake efficiency, in vitro anticancer effect, toxicity, and mechanisms were evaluated and analyzed. Results CM-SF NPs (<100 nm) with controllable particle size were prepared by SEDS. CM-SF NPs had a time-dependent intracellular uptake ability, which led to an improved inhibition effect on colon cancer cells. Interestingly, the anticancer effect of CM-SF NPs was improved, while the side effect on normal human colon mucosal epithelial cells was reduced by a concentration of ~10 μg/mL. The anticancer mechanism involves cell-cycle arrest in the G 0 /G 1 and G 2 /M phases in association with inducing apoptotic cells. Conclusion The natural compound-loaded SF nanoplatform prepared by SEDS indicates promising colon cancer-therapy potential.

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Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies

Cited by 414 publications

References 105 publications

The Anti-Adhesive Effect of Curcumin on Candida albicans Biofilms on Denture Materials

The Anti-Adhesive Effect of Curcumin on Candida albicans Biofilms on Denture Materials

MicroRNA: A novel target of curcumin in cancer therapy

Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

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