Phytophotodermatitis: a diagnosis to consider

Machado, Marta; Vidal, Rita Lacerda; Cardoso, Patrícia Cristina; Coelho, Sónia

doi:10.1136/bcr-2015-213388

Cited by 10 publications

(4 citation statements)

References 3 publications

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“…Phytophotodermatitis is a cutaneous inflammatory reaction caused by the interaction of light sensitising botanical substances called furocoumarins, with ultraviolet light (specifically long wave UVA) 1–3. The UV activated furocoumarins damage cells by binding to nuclear DNA and RNA and cause disruption of the cell membrane, resulting in oedema and cell necrosis 4.…”

Section: Discussionmentioning

confidence: 99%

Severe phytophotodermatitis from fig sap: a little known phenomenon

Redgrave

Solomon

2021

BMJ Case Rep

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A 46-year-old arborist with no medical history presented to the emergency department with a confluent blistering, erythematous, non-pruritic, painful rash covering both arms circumferentially and the back of his neck. He sought medical advice as his arms were becoming more painful and swollen with blister formation, despite aloe vera cream and wet towel wraps. He recalled that 2 days previously he had been pruning a fig tree on a hot sunny day. He was wearing a t-shirt and his forearms had been exposed to a large quantity of fig sap, while he was working under direct sunlight. On examination, there were several blisters with no superimposed infection. He was diagnosed with phytophotodermatitis and referred to a regional burns unit. He recovered well with simple dressings and a course of antibiotics. At present, he has made a good recovery with no long-term sequelae such as skin hyperpigmentation or hypopigmentation.

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Section: Discussionmentioning

confidence: 99%

Severe phytophotodermatitis from fig sap: a little known phenomenon

Redgrave

Solomon

2021

BMJ Case Rep

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“…string trimmer) dermatitis. With any common domestic vegetation, children who play outside may be exposed [35]. Rue is used as an herbal medicine for sprains, rheumatic pains, bruises, burns, and as an anti-parasitic agent and insect repellant [35][36][37].…”

Section: Rutaceaementioning

confidence: 99%

Phytophotodermatitis

Nguyen¹,

Muhammad²,

Lee³

2020

Dermatological Manual of Outdoor Hazards

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PUVAPsoralen and Ultraviolet A Radiation ROS Reactive Oxygen Species UVA Ultraviolet A Radiation Background/IntroductionCertain plant compounds may be toxic via direct human skin contact, while others may become phototoxic when combined with light. Dr. Robert Klaber originally coined the term "phytophotodermatitis" in a 1942 publication of the British Journal of Dermatology and Syphilis. Dr. Klaber suggested this term to describe the phenomenon of human skin eruptions produced by photosensitizing plants and their extracts upon exposure to sunlight [1]. Phytophotodermatitis may have only recently been coined as a term, but historical characterizations have been described as far back as 2000 B.C. in Egypt [2]. Egyptians used the Apiaceae plant family species Ammi majus, also known as false Bishop's Weed, to treat vitiligo [2,3]. Apiaceae (formerly known as Umbelliferae) is among the commonly implicated plant families along with Rutaceae and

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“…Phytophotodermatitis, or lime disease, occurs when plant material containing psoralens or furocoumarins touch skin that is subsequently exposed to ultraviolet radiation [4]. Within 24 hours, erythematous-irregular patches and streaks will appear, followed by vesicle and large bullae formation (Figure 1) [4,6]. A burning sensation often accompanies the rash [6].…”

Section: Phytophotodermatits (Lime Disease)mentioning

confidence: 99%

“…Within 24 hours, erythematous-irregular patches and streaks will appear, followed by vesicle and large bullae formation (Figure 1) [4,6]. A burning sensation often accompanies the rash [6]. Lesions are replaced by hyperpigmented macules, which usually fade after a few months [4].…”

Section: Phytophotodermatits (Lime Disease)mentioning

confidence: 99%

Phytodermatitis: A Brief Review of Human Skin Reactions Caused by the Kingdom Plantae

Brandenburg¹

2019

J Plant Pathol Res

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Many organisms of the kingdom Plantae may cause skin reactions when contacted or ingested. Those involved in work and recreation in the great outdoors as well as gardeners and other plant enthusiasts are well aware of this. While Toxicodendron dermatitis from poison ivy, oak, and sumac is the most common cause of allergic contact dermatitis (ACD) in the United States, this is just the tip of the iceberg. Numerous other species of plants are also known causes of ACD, producing a multitude of molecular culprits. Reactions, however, are not limited to type 4 hypersensitivities. Irritant contact dermatitis, phytophotodermatitis or lime disease, and urticarial rashes also occur when certain species come in contact with skin. Furthermore, ingestion of certain plant species may cause rare toxidrome skin eruptions. This paper reviews all of these major known types of phytodermatitis.

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Phytophotodermatitis: a diagnosis to consider

Cited by 10 publications

References 3 publications

Severe phytophotodermatitis from fig sap: a little known phenomenon

Severe phytophotodermatitis from fig sap: a little known phenomenon

Phytophotodermatitis

Phytodermatitis: A Brief Review of Human Skin Reactions Caused by the Kingdom Plantae

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