Phytophotodermatitis

Nguyen, Daniel A.; Muhammad, Muneeza K.; Lee, Grace L.

doi:10.1007/978-3-030-37782-3_4

Cited by 3 publications

(3 citation statements)

References 70 publications

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“…Phototoxic furanocoumarins are common in the epidermis of species in the Umbelliferae and Rutaceae, and in plants such as wild parsley or citrus they are a source of phytophotodermatitis—light‐dependent skin irritation in humans (Nguyen et al, 2020). Thus, it is logical to hypothesize that they may function as an anti‐herbivore defense.…”

Section: So Production By Endogenous Photosensitizers In Plant Biotic...mentioning

confidence: 99%

Singlet oxygen signalling and its potential roles in plant biotic interactions

Goggin,

Fischer

2024

Plant Cell & Environment

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Singlet oxygen (SO) is among the most potent reactive oxygen species, and readily oxidizes proteins, lipids and DNA. It can be generated at the plant surface by phototoxins in the epidermis, acting as a direct defense against pathogens and herbivores (including humans). SO can also accumulate within mitochondria, peroxisomes, cytosol and the nucleus through multiple enzymatic and nonenzymatic processes. However, the majority of research on intracellular SO generation in plants has focused on transfer of light energy to triplet oxygen by photopigments from the chloroplast. SO accumulates in response to diverse stresses that perturb chloroplast metabolism, and while its high reactivity limits diffusion distances, it participates in retrograde signalling through the EXECUTER1 sensor, generation of carotenoid metabolites and possibly other unknown pathways. SO thereby reprogrammes nuclear gene expression and modulates hormone signalling and programmed cell death. While SO signalling has long been known to regulate plant responses to high‐light stress, recent literature also suggests a role in plant interactions with insects, bacteria and fungi. The goals of this review are to provide a brief overview of SO, summarize evidence for its involvement in biotic stress responses and discuss future directions for the study of SO in defense signalling.

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Section: So Production By Endogenous Photosensitizers In Plant Biotic...mentioning

confidence: 99%

Singlet oxygen signalling and its potential roles in plant biotic interactions

Goggin,

Fischer

2024

Plant Cell & Environment

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“…Phototoxic furanocoumarins are common in the epidermis of species in the Umbelliferae, and Rutaceae, and in plants such as wild parsley or citrus they are a source of phytophotodermatitis light-dependent skin irritation in humans (Nguyen et al, 2020). Thus, it is logical to hypothesize that they may function as an antiherbivore defense.…”

Section: So Production By Photosensitizers In Plant Biotic Interactionsmentioning

confidence: 99%

Fun in the Sun: Singlet Oxygen Harnessing the Power of Light in Response to Biotic Stresses

Goggin,

Fischer

2023

Preprint

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Singlet Oxygen (SO) is among the most potent reactive oxygen species, and readily oxidizes proteins, lipids, and DNA. It can be generated at the plant surface by phototoxins in the epidermis, acting as a direct defense against pathogens and herbivores (including humans). SO can also accumulate within mitochondria, peroxisomes, cytosol, and the nucleus through multiple enzymatic and non-enzymatic processes. However, the primary location of SO in plants is in the chloroplast, where it results from transfer of light energy from PhotosystemII to triplet oxygen. SO accumulates in response to diverse stresses that perturb chloroplast metabolism, and while its short half-life precludes exiting the chloroplast, it participates in retrograde signaling through the EXECUTER1 sensor, generation of carotenoid metabolites, and possibly other unknown pathways. SO thereby reprograms nuclear gene expression and modulates hormone signaling and programmed cell death. While SO signaling has long been known to regulate plant responses to high-light stress, recent literature also suggests a role in plant interactions with insects, bacteria, and fungi. The goals of this review are to provide a brief overview of SO, summarize evidence for its involvement in biotic stress responses, and discuss future directions for the study of SO in signaling and defense.

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“…; Lauraceae) may contain photosensitizing molecules, such as flavins, cyanins, porphyrins and hydrocarbons, and can cause skin erythema or even cancer ( Kejlová et al, 2010 ). The photosensitizing furocoumarin psoralen found in some EOs is known to induce phototoxic effects and may induce skin irritation or cancer, like phytophotodermatitis, after formation of covalent DNA adducts when exposed to ultraviolet A or solar light ( Averbeck et al, 1990 ; Averbeck and Averbeck, 1998 ; Nguyen et al, 2020 ). However, in the dark, the same oil is neither cytotoxic nor mutagenic by itself.…”

Section: Eos and Their Bio-functional Properties – Risks And Side Eff...mentioning

confidence: 99%

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

et al. 2022

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Essential oils (EOs) and their individual volatile organic constituents have been an inherent part of our civilization for thousands of years. They are widely used as fragrances in perfumes and cosmetics and contribute to a healthy diet, but also act as active ingredients of pharmaceutical products. Their antibacterial, antiviral, and anti-inflammatory properties have qualified EOs early on for both, the causal and symptomatic therapy of a number of diseases, but also for prevention. Obtained from natural, mostly plant materials, EOs constitute a typical example of a multicomponent mixture (more than one constituent substances, MOCS) with up to several hundreds of individual compounds, which in a sophisticated composition make up the property of a particular complete EO. The integrative use of EOs as MOCS will play a major role in human and veterinary medicine now and in the future and is already widely used in some cases, e.g., in aromatherapy for the treatment of psychosomatic complaints, for inhalation in the treatment of respiratory diseases, or topically administered to manage adverse skin diseases. The diversity of molecules with different functionalities exhibits a broad range of multiple physical and chemical properties, which are the base of their multi-target activity as opposed to single isolated compounds. Whether and how such a broad-spectrum effect is reflected in natural mixtures and which kind of pharmacological potential they provide will be considered in the context of ONE Health in more detail in this review.

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Phytophotodermatitis

Cited by 3 publications

References 70 publications

Singlet oxygen signalling and its potential roles in plant biotic interactions

Singlet oxygen signalling and its potential roles in plant biotic interactions

Fun in the Sun: Singlet Oxygen Harnessing the Power of Light in Response to Biotic Stresses

Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being

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