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Diarrhoea is a condition characterized by a variation in the bowel movement. It is one of the major health issues in developing countries. Its severity is more in children’s. Diarrhoea causes severe dehydration and some time it may lead to death. Globally, over 5 million children’s are dying each year because of diarrhoea. In the present scenario, herbal medicines are used by the people in a wider range because of its safety as compared to synthetic drugs. So it is very crucial to identify and investigate available natural drugs for treating diarrhoea. Hence, the present study endeavor the evaluation of antidiarrhoeal activity of Achyranthus aspera. The anti-diarrhoeal activity was performed by using different animal models like castor oil-induced diarrhoea, prostaglandin-E2 induced enteropooling and gastrointestinal motility test. All the extracts of Achyranthus aspera showed considerable antidiarrhoeal activity in all the three animal models by reducing diarrhoeal episodes. The findings of the present investigation revealed the significant antidiarrhoeal property of Achyranthes aspera. Hence this plant can be used in the suitable form as an alternative to available synthetic antidiarrhoeal medicines which are not completely safe. Thus the adverse effects of synthetic drugs can be minimized by reducing its use.
Diarrhoea is a condition characterized by a variation in the bowel movement. It is one of the major health issues in developing countries. Its severity is more in children’s. Diarrhoea causes severe dehydration and some time it may lead to death. Globally, over 5 million children’s are dying each year because of diarrhoea. In the present scenario, herbal medicines are used by the people in a wider range because of its safety as compared to synthetic drugs. So it is very crucial to identify and investigate available natural drugs for treating diarrhoea. Hence, the present study endeavor the evaluation of antidiarrhoeal activity of Achyranthus aspera. The anti-diarrhoeal activity was performed by using different animal models like castor oil-induced diarrhoea, prostaglandin-E2 induced enteropooling and gastrointestinal motility test. All the extracts of Achyranthus aspera showed considerable antidiarrhoeal activity in all the three animal models by reducing diarrhoeal episodes. The findings of the present investigation revealed the significant antidiarrhoeal property of Achyranthes aspera. Hence this plant can be used in the suitable form as an alternative to available synthetic antidiarrhoeal medicines which are not completely safe. Thus the adverse effects of synthetic drugs can be minimized by reducing its use.
Asthma in chronic condition is very tedious to cure and which is very common disease. The aim of study was to evaluate anti-asthmatic activity root part of. A. aspera. Collection of root part of is done from Rahata District Ahmednagar (Maharashtra). For authentication of of Achyranthes aspera A. aspera Herbarium of plant was made and sent to Biological Survey of India, Pune. The collected material was proceeded for air dry at 35-40º C and then it was pulverized in electric grinder. Extraction of obtained powder was completed in ethanol,Water-ethanol and Petroleum ether by using Soxhlet Apparatus.. The presence of Steroids, flavonides, phenolic compound, glycosides, tannins, saponins, alkaloids and carbohydrates were revealed by phytochemical screening. The extract obtained were of aerial part of screened for anti-asthmatic activity. The Petroleum ether extract of root part was result the right side shift of dose Achyranthes aspera response curve in isolated goat chain and isolated guinea pig so it is indicating antiasthmatic action of drug extract.
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