Antidiarrhoeal Potential of various Solvent Extracts of Achyranthes aspera against three diverse diarrhoeal animal models

Ahmed, Syed Sagheer; K, Chandra Prakash; Tabassum, Saba; Salma, Noor; H, Ahalya Devi K

doi:10.52711/0974-360x.2021.00722

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Furthermore, in the castor oil-induced diarrheal model, these extracts reduced the frequency of defecation and the total weight of wet diarrhea compared to the control group. [25] 10. Anti-malarial Activity :…”

Section: Analgesic Activitymentioning

confidence: 99%

A Comprehensive Review on Medicinal Applications and Pharmacological Activities of Tridex procumbens

2024

IRJMETS

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Tridax procumbens Linn, a widely distributed medicinal plant, has garnered significant attention due to its diverse medicinal properties. This review aims to comprehensively evaluate its medicinal importance based on scientific literature and traditional knowledge. Tridax procumbens exhibits a plethora of pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial, antidiabetic, and wound healing effects. Additionally, it shows promise in the management of various ailments such as arthritis, malaria, dysentery, and skin disorders. The plant's therapeutic efficacy can be attributed to its rich phytochemical profile, which includes flavonoids, alkaloids, phenolics, and terpenoids. Furthermore, studies have elucidated the underlying mechanisms of action for many of its bioactive compounds. Despite its promising medicinal properties, further research is needed to fully understand the pharmacological mechanisms and optimize its therapeutic applications. Tridax procumbens holds immense potential as a valuable source of natural remedies and warrants continued investigation for its integration into modern medicine.

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Section: Analgesic Activitymentioning

confidence: 99%

A Comprehensive Review on Medicinal Applications and Pharmacological Activities of Tridex procumbens

2024

IRJMETS

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“…[ 1 ] Medicinal plants are in high demand right now and their adaptation is expanding due to their higher availability and lower toxicity to humans. [ 2 ] Psidium guajava , commonly called guava, is one of the well-known ancient medicinal plants that belongs to the family Myrtaceae. It is available in topical areas like Bangladesh, India, Pakistan, South America, and Indonesia.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis of Silver Nanoparticles of Psidium guajava Leaf Extract and Evaluation for Its Antibacterial Property

Raghupathy,

Sivalingam,

Brahma

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Nonessential heavy metals are toxic to human health. In this study, mercury, a hazardous metal, was detected by colorimetric analysis using Murraya koenigii. The eco-friendliness of this method was also emphasized. UV spectrum is a broad peak observed at 200–250 nm in P. guajava leaf extracts. The UV spectrum of green synthesized P. guajava exhibited an absorption band of 418 nm, which confirms the nanoparticle synthesis. FTIR analysis of the vibrational peak around 3307 cm−1 is assigned to ν(O–H) stretching that could possibly emanate from carbohydrates or phenolics. The peaks found around 2917 and 2849 cm−1 are ascribed to the –C-H stretch of the alkyl group, and the peak around 1625 cm−1 is due to the enolic β-diketones or -C = O stretch of carboxylic acids, while the corresponding -C-O stretch is observed around 1375 and 1029 cm−1. The assignment of peaks is similar. It is clear from the SEM image that the constituent parts were non-uniform sphere-shaped, agglomerated, and of an average size of 30.9 nm. XRD analysis was utilized to determine the structural characteristics and crystalline nature of P. guajava. The observed intensity peaks at 32.35°, 36.69°, 39.24°, 44.76°, 59.42°, and 67.35° represent the 2θ values for P. guajava in the diffraction pattern, aligning with the values in the standard database. The synthesized AgNPs tested antibacterial properties against various strains of microorganisms, including Escherichia coli, 25 μg/mL 6.02 ± 0.17 and 100 μg/mL 7.3 ± 0.05, Staphylococcus aureus, 25 μg/mL 05.02 ± 0.07 and 100 μg/mL 11.3 ± 1.12, Streptococcus mutans, 25 μg/mL 04.02 ± 0.19 and 100 μg/mL 11.1 ± 0.11, Enterococcus faecalis, 25 µg/mL 0.8.05 ± 0.11 and 100 µg/mL 11.7 ± 0.02. The short novelty of Psidium guajava (guava) lies in its potential relevance to human health, as it has been found to possess bioactive compounds with various medicinal properties, such as antimicrobial, antioxidant, and anti-inflammatory activities, making it a promising natural resource for therapeutic applications.

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“…Medicinal plants are in high demand right now and their adaptation is expanding due to their higher availability and lower toxicity to humans [ 13 ]. Remarkably, 25% of the modern medications are derived directly or indirectly from plants, proving the strong basis for plant-derived medicine [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis and Characterization of Silver Nanoparticles of Psidium guajava Leaf Extract and Evaluation for Its Antidiabetic Activity

Sreeharsha

Ahmed²,

Bharathi³

et al. 2022

Molecules

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Diabetes mellitus (DM) and its complications are a severe public health concern due to the high incidence, morbidity, and mortality rates. The present study aims to synthesize and characterize silver nanoparticles (AgNPs) using the aqueous leaf extract of Psidium guajava (PGE) for investigating its antidiabetic activity. Psidium guajava silver nanoparticles (PGAg NPs) were prepared and characterized by various parameters. The in vivo study was conducted using PGE and PGAg NPs in Streptozotocin (STZ)-induced diabetic rats to assess their antidiabetic properties. STZ of 55 mg/kg was injected to induce diabetes. The PGE, PGAg NPs at a dose of 200 and 400 mg/kg and standard drug Metformin (100 mg/kg) were administered daily to diabetic rats for 21 days through the oral route. Blood glucose level, body weight changes, lipid profiles, and histopathology of the rats’ liver and pancreas were examined. In the diabetic rats, PGE and PGAg NPs produced a drastic decrease in the blood glucose level, preventing subsequent weight loss and ameliorating lipid profile parameters. The histopathological findings revealed the improvements in pancreas and liver cells due to the repercussion of PGE and PGAg NPs. A compelling effect was observed in all doses of PGE and PGAg NPs; however, PGAg NPs exhibited a more promising result. Thus, from the results, it is concluded that the synthesized PGAg NPs has potent antidiabetic activity due to its enhanced surface area and smaller particle size of nanoparticles.

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Antidiarrhoeal Potential of various Solvent Extracts of Achyranthes aspera against three diverse diarrhoeal animal models

Cited by 4 publications

References 16 publications

A Comprehensive Review on Medicinal Applications and Pharmacological Activities of Tridex procumbens

A Comprehensive Review on Medicinal Applications and Pharmacological Activities of Tridex procumbens

Phytochemical Analysis of Silver Nanoparticles of Psidium guajava Leaf Extract and Evaluation for Its Antibacterial Property

Green Synthesis and Characterization of Silver Nanoparticles of Psidium guajava Leaf Extract and Evaluation for Its Antidiabetic Activity

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