Phytonanotechnology: a greener approach for biomedical applications

Javed, Rabia; Ghonaim, Reem; Shathili, Abdulrahman M.; Khalifa, Shaden A. M.; El‐Seedi, Hesham R.

doi:10.1016/b978-0-12-821467-1.00009-4

Cited by 15 publications

(9 citation statements)

References 171 publications

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“…Phyto Nanoparticles (PNPs) have proved their wide range of applications in biomedicine due to their extraordinary capacity to act as reducing and stabilizing agents. [1] Plant-mediated nanoparticle synthesis is considered a green chemistry technique due to the absence of harmful solvents or reagents. Simple, dependable, cost-effective, and ecologically friendly.…”

Section: Introductionmentioning

confidence: 99%

Tinospora cordifolia Stem Extract-mediated Green Synthesis of Selenium Nanoparticles and its Biological Applications

Puri¹,

Patil²

2022

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Background: According to a literature review Tinospora cordifolia possess alkaloids, tannins, flavonoids, glycosides, and steroids with anti-cancer potential. However, there is a lack of scientific evidence on the green synthesis of selenium nanoparticles from the stem of T. cordifolia and its biological activities. Objectives: This study is intended to synthesize Selenium Nanoparticles using T. cordifolia stem extract, characterise them, and evaluate them in-vitro for antioxidant and anticancer activity. Materials and Methods: The T. cordifolia Selenium Nanoparticles (TC-SeNPs) were synthesised by reducing selenious acid with T. cordifolia stem extract. TC-SeNPs were characterized by UV-Vis, FTIR, XRD, FE-SEM, EDAX and ICP-AES, further evaluated for in-vitro antioxidant activity by DPPH free radical scavenging test and reducing power capacity. The MTT assay of TC-SeNP was carried out in-vitro in the human breast cancer cells line (MCF-7) to determine the anticancer activity. Results:The UV-spectroscopy of TC-SeNPs showed maximum absorbance at 285 nm, which is the characteristic feature of SeNP. According to DLS, SEM, and TEM images, the size of TC-SeNPs was between 100-200 nm and was stable with a Zeta potential of -23.9mV. XRD analysis confirmed the crystallinity of TC-SeNPs. Selenium in TC-SeNP was verified in EDAX analysis (63.36% weight) and ICP-AES 68.08 ±12.2 µg/ml selenium content. The IC 50 value 28.62 ± 0.63 µg/mL and EC 50 (62.50 ± 1.21 µg/mL) values indicated that the TC-SeNPs possess significant antioxidant capacity. MTT assay showed TC-SeNPs were cytotoxic to MCF-7 cell with IC 50 values (31.29 ± 0.22µg/mL), suggesting that TC-SeNPs display moderate cytotoxicity that could dose-dependently inhibit cell proliferation. Conclusion: Thus, experimental evidence provides insight into the successful synthesis of the selenium nanoparticle from the stem of T. cordifolia, its potential therapeutic value, and the prospect of developing an anti-cancer TC-SeNPs formulation.

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Section: Introductionmentioning

confidence: 99%

Tinospora cordifolia Stem Extract-mediated Green Synthesis of Selenium Nanoparticles and its Biological Applications

Puri¹,

Patil²

2022

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“…In another study, chitosan stabilized CuO NPs were fabricated via co-precipitation method using copper acetate precursor. 500 °C was the calcination temperature that produced < 35 nm sized NPs (Javed et al 2021a ). Similarly, PEG and PVP capped CuO NPs of 27 nm size were fabricated using co-precipitation by (Javed et al 2017 ).…”

Section: Synthesis Techniquesmentioning

confidence: 99%

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Naz

Gul

Zia

et al. 2023

Appl Microbiol Biotechnol

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Versatile nature of copper oxide nanoparticles (CuO NPs) has made them an imperative nanomaterial being employed in nanomedicine. Various physical, chemical, and biological methodologies are in use for the preparation of CuO NPs. The physicochemical and biological properties of CuO NPs are primarily affected by their method of fabrication; therefore, selectivity of a synthetic technique is immensely important that makes these NPs appropriate for a specific biomedical application. The deliberate use of CuO NPs in biomedicine questions their biocompatible nature. For this reason, the present review has been designed to focus on the approaches employed for the synthesis of CuO NPs; their biomedical applications highlighting antimicrobial, anticancer, and antioxidant studies; and most importantly, the in vitro and in vivo toxicity associated with these NPs. This comprehensive overview of CuO NPs is unique and novel as it emphasizes on biomedical applications of CuO NPs along with its toxicological assessments which would be useful in providing core knowledge to researchers working in these domains for planning and conducting futuristic studies. Key Points • The recent methods for fabrication of CuO nanoparticles have been discussed with emphasis on green synthesis methods for different biomedical approaches. • Antibacterial, antioxidant, anticancer, antiparasitic, antidiabetic, and antiviral properties of CuO nanoparticles have been explained. • In vitro and in vivo toxicological studies of CuO nanoparticles exploited along with their respective mechanisms. Graphical Abstract

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“…Despite promising effects in cancer treatment, their clinical applications in RT are few. This is possibly related to their low bioavailability, which can be overcome with the use of nanocarriers [77][78][79].…”

Section: Natural Products As Radiosensitizersmentioning

confidence: 99%

Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy

Gomes

Franco²

2022

Pharmaceutics

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Cancer is responsible for a significant proportion of death all over the world. Therefore, strategies to improve its treatment are highly desired. The use of nanocarriers to deliver anticancer treatments has been extensively investigated and improved since the approval of the first liposomal formulation for cancer treatment in 1995. Radiotherapy (RT) is present in the disease management strategy of around 50% of cancer patients. In the present review, we bring the state-of-the-art information on the combination of nanocarrier-assisted delivery of molecules and RT. We start with formulations designed to encapsulate single or multiple molecules that, once delivered to the tumor site, act directly on the cells to improve the effects of RT. Then, we describe formulations designed to modulate the tumor microenvironment by delivering oxygen or to boost the abscopal effect. Finally, we present how RT can be employed to trigger molecule delivery from nanocarriers or to modulate the EPR effect.

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Phytonanotechnology: a greener approach for biomedical applications

Cited by 15 publications

References 171 publications

Tinospora cordifolia Stem Extract-mediated Green Synthesis of Selenium Nanoparticles and its Biological Applications

Tinospora cordifolia Stem Extract-mediated Green Synthesis of Selenium Nanoparticles and its Biological Applications

Synthesis, biomedical applications, and toxicity of CuO nanoparticles

Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy

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