Phytofabrication of cupric oxide nanoparticles using Simarouba glauca and Celastrus paniculatus extracts and their enhanced apoptotic inducing and anticancer effects
“…46 Nitric oxide and the pro-oxidant enzyme myeloperoxidase (MPO) were playing a fundamental role in controlling cellular stress and constituting a key component of the innate immune defense system. 47 Excessive production of NO and MPO− derived oxidants have been associated with tissue damage as well as the onset and the progression of chronic inflammationrelated disorders including cancer involved in EAC-induced toxicity, this agrees with our findings that demonstrated a significant increase in NO level and MPO activity in the selected organs. Our results are in line with ELAblack et al (2020) 48 that explained the increase of NO level may be due to the elevation of lipid peroxidation levels and its product MDA that can enhance host cells, fundamentally macrophages/ monocytes, to produce NO by stimulation of iNOS activity causing tissue damage.…”
Section: ■ Discussionsupporting
confidence: 93%
“…Nitric oxide and the pro-oxidant enzyme myeloperoxidase (MPO) were playing a fundamental role in controlling cellular stress and constituting a key component of the innate immune defense system . Excessive production of NO and MPO–derived oxidants have been associated with tissue damage as well as the onset and the progression of chronic inflammation-related disorders including cancer involved in EAC-induced toxicity, this agrees with our findings that demonstrated a significant increase in NO level and MPO activity in the selected organs.…”
Section: Discussionsupporting
confidence: 90%
“…Hematological Parameters. The Ehrlich solid tumor (EST) group shows a considerable significant drop in Hb %, lymphocyte, and red blood cell (RBC) count by 29% (10.53 ± 0.29), 22% (53.00 ± 1.73), and 36% (3.30 ± 0.17), respectively, as compared with the normal group (14.90 ± 0.30, 68.17 ± 1.01, and 5.14 ± 0.07, respectively), accompanied by a significant increase in white blood cell47 ± 0.29), 22% (64.53 ± 0.90), and 44% (4.74 ± 0.17), and by 20% (12.67 ± 0.16), 29% (68.37 ± 0.18), and 36% (4.49 ± 0.14), respectively, as compared with the Ehrlich group, accompanied by a significant decrease in WBC count and percentage of neutrophils and monocytes by 39% (6.60 ± 0.05), 15% (26.33 ± 0.72), and 35% (1.41 ± 0.06), respectively, and by 22% (8.50 ± 0.34), 27% (22.37 ± a…”
Current research is focused on cancer treatments other than chemotherapy medications, particularly those derived from natural sources. The goal of this work was to look at the anticancer and biomarker properties of a methanolic extract of Annona squamosa leaves and their extract-loaded noisome. A. squamosa leaves extract and their leaves extract-loaded noisome were prepared. Transmission electron microscopy was used to screen the size of the niosomes loaded with the A. squamosa L. leaves extract. The tumor size, blood picture (hemoglobin, red blood cells, white blood cells), liver functions, kidney function, oxidative stress, and inflammatory markers were evaluated to assess the potential anticancer activity of the A. squamosa leaves extract and A. squamosa leaves extract-loaded noisome in Ehrlich ascites carcinoma. A. squamosa L. leaves extract was found to be an effective anticancer treatment. The protective effect of the loaded extract showed more significant results. All treated groups showed a lower tumor volume compared to the positive control. Liver and kidney functions were improved, and inflammatory markers were decreased. Oxidative stress was improved in tumor, liver, and kidney tissues. A. squamosa leaves contain major anticancer compounds that in general help most enzymes of the liver and kidney and other injured organs to return to their normal levels.
“…46 Nitric oxide and the pro-oxidant enzyme myeloperoxidase (MPO) were playing a fundamental role in controlling cellular stress and constituting a key component of the innate immune defense system. 47 Excessive production of NO and MPO− derived oxidants have been associated with tissue damage as well as the onset and the progression of chronic inflammationrelated disorders including cancer involved in EAC-induced toxicity, this agrees with our findings that demonstrated a significant increase in NO level and MPO activity in the selected organs. Our results are in line with ELAblack et al (2020) 48 that explained the increase of NO level may be due to the elevation of lipid peroxidation levels and its product MDA that can enhance host cells, fundamentally macrophages/ monocytes, to produce NO by stimulation of iNOS activity causing tissue damage.…”
Section: ■ Discussionsupporting
confidence: 93%
“…Nitric oxide and the pro-oxidant enzyme myeloperoxidase (MPO) were playing a fundamental role in controlling cellular stress and constituting a key component of the innate immune defense system . Excessive production of NO and MPO–derived oxidants have been associated with tissue damage as well as the onset and the progression of chronic inflammation-related disorders including cancer involved in EAC-induced toxicity, this agrees with our findings that demonstrated a significant increase in NO level and MPO activity in the selected organs.…”
Section: Discussionsupporting
confidence: 90%
“…Hematological Parameters. The Ehrlich solid tumor (EST) group shows a considerable significant drop in Hb %, lymphocyte, and red blood cell (RBC) count by 29% (10.53 ± 0.29), 22% (53.00 ± 1.73), and 36% (3.30 ± 0.17), respectively, as compared with the normal group (14.90 ± 0.30, 68.17 ± 1.01, and 5.14 ± 0.07, respectively), accompanied by a significant increase in white blood cell47 ± 0.29), 22% (64.53 ± 0.90), and 44% (4.74 ± 0.17), and by 20% (12.67 ± 0.16), 29% (68.37 ± 0.18), and 36% (4.49 ± 0.14), respectively, as compared with the Ehrlich group, accompanied by a significant decrease in WBC count and percentage of neutrophils and monocytes by 39% (6.60 ± 0.05), 15% (26.33 ± 0.72), and 35% (1.41 ± 0.06), respectively, and by 22% (8.50 ± 0.34), 27% (22.37 ± a…”
Current research is focused on cancer treatments other than chemotherapy medications, particularly those derived from natural sources. The goal of this work was to look at the anticancer and biomarker properties of a methanolic extract of Annona squamosa leaves and their extract-loaded noisome. A. squamosa leaves extract and their leaves extract-loaded noisome were prepared. Transmission electron microscopy was used to screen the size of the niosomes loaded with the A. squamosa L. leaves extract. The tumor size, blood picture (hemoglobin, red blood cells, white blood cells), liver functions, kidney function, oxidative stress, and inflammatory markers were evaluated to assess the potential anticancer activity of the A. squamosa leaves extract and A. squamosa leaves extract-loaded noisome in Ehrlich ascites carcinoma. A. squamosa L. leaves extract was found to be an effective anticancer treatment. The protective effect of the loaded extract showed more significant results. All treated groups showed a lower tumor volume compared to the positive control. Liver and kidney functions were improved, and inflammatory markers were decreased. Oxidative stress was improved in tumor, liver, and kidney tissues. A. squamosa leaves contain major anticancer compounds that in general help most enzymes of the liver and kidney and other injured organs to return to their normal levels.
“…Transition metal oxide nanoparticles, such as CuO NPs, have been broadly used for various applications, including as sensors, catalysts, semiconductors, antimicrobial agents, supercapacitors, etc. [ 4 , 5 , 6 , 7 ]. Additionally, CuO nanoparticles have recently been used in biomedical and cancer applications owing to their attractive chemical properties.…”
The active and inexpensive catalyst cupric oxide (CuO) loaded foliar fertilizer of graphitic carbon nitride (g-C3N4) is investigated for biological applications due to its low cost and easy synthesis. The synthesized CuO NPs, bulk g-C3N4, exfoliated g-C3N4, and different weight percentages of 30 wt%, 40 wt%, 50 wt%, 60 wt%, and 70 wt% CuO-loaded g-C3N4 are characterized using different analytical techniques, including powder X-ray diffraction, scanning electron microscopy, energy dispersive X-ray analysis, and ultraviolet-visible spectroscopy. The nanocomposite of CuO NPs loaded g-C3N4 exhibits antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). The 20 μg/mL of 70 wt% CuO/g-C3N4 nanocomposite showed an efficiency of 98% for Gram-positive bacteria, 80% for E. Coli, and 85% for P. aeruginosa. In the same way, since the 70 wt% CuO/g-C3N4 nanocomposite showed the best results for antibacterial activity, the same compound was evaluated for anti-fungal activity. For this purpose, the fungi Fusarium oxysporum and Trichoderma viride were used. The anti-fungal activity experiments were not conducted in the presence of sunlight, and no appreciable fungal inhibition was observed. As per the literature, the presence of the catalyst g-C3N4, without an external light source, reduces the fungal inhibition performance. Hence, in the future, some modifications in the experimental conditions should be considered to improve the anti-fungal activity.
“…A variety of possible photo-sensitive nano-semiconductor metal halide/oxides/sulphide, such as TiO2, ZnO, CuO, BiFeO3 and Carbon-based nanostructures have been produced and employed as photocatalysts for water purification, thanks to rapid advances in nanotechnology [11]. This innovative interdisciplinary branch of science and technology leads to the formation of different morphologies like nanoparticles [12-16][17], nanotubes [18,19], nanorods [20,21], nanocubes [22] and nanosheets [23] by using numerous advanced methods such as hydrothermal, solvothermal, sol-gel, microwave, co-precipitation methods [24] with different applications in many fields such as from basic chemistry [25][26][27][28], physics [29][30][31] to the advanced electronics [32][33][34][35][36], nanotechnology [37][38][39][40][41], biotechnology [42][43][44][45][46][47] by altering the properties like mechanical [17,48] physical [49][50][51] and magnetic [52,53] so they come up with an ideal of environmental friendly [54], with a motto of decreasing the pollutions [55,…”
Pollution by textile dyes on waterbodies is an issue for both human health and the environment. To remove/degrade dyes, many approaches (coagulation, membrane separation, and adsorption) have been investigated. However, the use of semiconductor-assisted materials in conjunction with sustainable solar energy has emerged as a possible solution to the problem. Although single component photocatalysts have been tested, composites of semiconductor materials are being employed owing to their low efficiency and stability due to the high recombination rate electron-hole pair and inefficient visible light absorption. By combining two or more semiconductor components, semiconductor heterojunction systems are created. Overall stability is increased by the synergistic impact of their features, such as adsorption and better charge carrier movement. This paper discusses current advances in advanced nanocomposite materials utilized as photocatalysts, as well as the utilization of heterojunctions, crystallinity, and doping to improve photocatalytic characteristics. The conclusion includes a summary, research gaps, and a forecast for the future. This study will aid in the development of efficient heterostructure photodegradation systems by providing a comprehensive appraisal of recent advances in demonstrating effective nanocomposites for photodegradation of Rhodamine B dye under ideal circumstances.
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