Phytoestrogens and liver disease

Lei, Barbara; Roncaglia, V.; Viganò, R.; Cremonini, Claudia; Maria, Nicola De; Buono, Maria Grazia Del; Manenti, F.; Villa, Erica

doi:10.1016/s0303-7207(02)00099-0

Cited by 22 publications

(17 citation statements)

References 10 publications

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“…However, when evaluating this relationship, confounding factors such as lifestyle, diet, socio-cultural and morphological differences that distinguish Asian and Western populations must be considered in the analysis . Several studies have discussed the potential effects of phytoestrogens in treating breast cancer, endometrial cancer, liver disease and prostate cancer (Fotsis et al, 1993;Strom et al, 1999;Adlercreutz et al, 2000b;Messina and Loprinzi, 2001;Lei et al, 2002). Additional research has shown that intestinal bacteria are seen as important in the metabolism of phytoestrogens and have the ability to refine phytoestrogens into compounds similar in structure to E 2 that protect against cancer (Xu et al, 1995).…”

Section: Human Health and Phytoestrogensmentioning

confidence: 99%

Phytoestrogens: a review of the present state of research

Ososki

Kennelly

2003

Phytotherapy Research

401

278

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Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health. The number of articles published on phytoestrogens has risen dramatically in the past couple decades. Further research continues to demonstrate the biological complexity of phytoestrogens, which belong to several different chemical classes and act through diverse mechanisms. This paper discusses the classification of phytoestrogens, methods of identification, their proposed mechanisms of action and botanical sources for phytoestrogens. The effects of phytoestrogens on breast and prostate cancers, cardiovascular disease, menopausal symptoms and osteoporosis will also be examined including research on benefits and risks.

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Section: Human Health and Phytoestrogensmentioning

confidence: 99%

Phytoestrogens: a review of the present state of research

Ososki

Kennelly

2003

Phytotherapy Research

401

278

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“….) have been reported by several epidemiological studies to be in association with the incidence of some hormone-dependant diseases (Roy et al, 1998;Andersen et al, 2002;Lei et al, 2002). For example, exposure to environmental estrogens has been associated with an increase in incidence of testicular and breast cancer, and compromised reproductive capacity (Byford et al, 2002;Diel et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Protection of mammalian cell used in biosensors by coating with a polyelectrolyte shell

Germain

Balaguer

Nicolas

et al. 2006

Biosensors and Bioelectronics

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“…Genistein has been demonstrated to have diverse biological activities including anticancer, antioxidant, and anti-inflammatory actions [114]. Epidemiological studies have demonstrated an inverse correlation between frequency of isoflavone-rich miso soup intake and HCC mortality [115], and a significantly lower intake of genistein in patients with HCC in comparison with cirrhosis [116], suggesting that consumption of genistein-rich soy foods may reduce the risk of HCC. In contrast, there are some opposing reports demonstrating no association between tofu consumption and HCC [117], and rather increased risk of HCC in patients with HBV and HCV infection with high consumption of genistein [118].…”

Section: Genisteinmentioning

confidence: 99%

Chemoprevention against hepatocellular carcinoma

Okano

Fujise

Abe

et al. 2011

Clin J Gastroenterol

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Since the majority of hepatocellular carcinoma (HCC) arises from a background of chronic liver diseases caused by infection with hepatitis C virus (HCV) and hepatitis B virus (HBV), chemoprevention targeting patients at high risk of HCC is feasible. In this review article, we summarize current knowledge of chemoprevention against HCC mostly using phytochemicals which have less toxicity than pharmaceutical agents. We describe in vivo and in vitro evidence and proposed mechanisms of beneficial effects of several compounds on the liver, including acyclic retinoid (ACR), angiotensin-converting enzyme inhibitors (ACEIs), caffeine, capsaicin, cepharanthine (CEP), cinnamaldehyde, curcumin, diallyl sulfide (DAS), eicosapentaenoic acid (EPA), epigallocatechin-3-gallate (EGCG), genistein, lycopene, resveratrol, silymarin, sulforaphane (SFN), and xanthohumol (XN). Because antihepatocarcinogenic effects by these compounds are mostly based on experimental studies, clinical evidence is urgently necessary.

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Phytoestrogens and liver disease

Cited by 22 publications

References 10 publications

Phytoestrogens: a review of the present state of research

Phytoestrogens: a review of the present state of research

Protection of mammalian cell used in biosensors by coating with a polyelectrolyte shell

Chemoprevention against hepatocellular carcinoma

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