Phytoestrogens: Adverse Effects on Reproduction in California Quail

Leopold, AS; Erwin, Monica; Oh, Jae Hwan; Browning, Brian L.

doi:10.1126/science.1246602

Cited by 190 publications

(81 citation statements)

References 7 publications

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“…[40,41] Consumption of plant material with abnormal content of phytoestrogens has been shown to decrease fertility in quail. [42] Intake of excess isoflavanoids (phytosterol) during child hood may lead to moderate decrease in male fertility, including reproductive capacity. [43] In an earlier report, we presented evidence on the effect of GA 3 on serum enzyme and biomarkers and on lipids, and blood cell count in male rat.…”

Section: Discussionmentioning

confidence: 99%

Effect of Plant Hormone Gibberellic Acid-3 on Rat Testicular Biomarkers and Its Histology

Suriamurthy¹

2017

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Section: Discussionmentioning

confidence: 99%

Effect of Plant Hormone Gibberellic Acid-3 on Rat Testicular Biomarkers and Its Histology

Suriamurthy¹

2017

WJPPS

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“…In the wild, one study found high levels of phytoestrogens in the leaves of stunted desert annuals in a dry year, leading ultimately to impaired reproduction when ingested by the California quail (Lophortyx californicus). In wet years, these quails bred normally and phytoestrogens were largely absent in these herbs (Leopold et al, 1976). Finally in captured cheetahs, cases of infertility and liver disease were attributed to the consumption of a soy-based diet and the exposure to high levels of isoflavones ( 50 mg/day; Setchell et al, 1987).…”

Section: Soy and Phytoestrogens As Potential Sources Of Endocrinedisrmentioning

confidence: 99%

Soy, phytoestrogens and their impact on reproductive health

Cederroth

Zimmermann

Nef

2012

Molecular and Cellular Endocrinology

190

117

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a b s t r a c tThere is growing interest in the potential health threats posed by endocrine-disrupting chemicals (EDCs) to the reproductive system. Soybean is the most important dietary source of isoflavones, an important class of phytoestrogen. While consumption of soy food or phytoestrogen supplements has been frequently associated with beneficial health effects, the potentially adverse effects on development, fertility, and the reproductive and endocrine systems are likely underappreciated. Here we review the available epidemiological, clinical and animal data on the effects of soy and phytoestrogens on the development and function of the male and female reproductive system, and weigh the evidence as to their detrimental impact.

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“…In addition, phytoestrogens could augment or inhibit estrogen negative feedback by binding to ERs in the anterior pituitary or hypothalamus and indirectly alter ovarian steroidogenesis (see below). Natural dietary exposures to phytoestrogens have been associated with cystic ovaries, irregular estrus, and anestrus in cattle (91), and reduced breeding success in California quail (92). Compromised follicular development (91) and reductions in luteal phase plasma progesterone and E 2 , as well as shortened luteal phases, have been reported in cycling ewes whereas increases in estradiol and cortisol have been reported in pregnant ewes (93,94).…”

Section: Ovarian Cyclicitymentioning

confidence: 99%

Cross-species and interassay comparisons of phytoestrogen action.

Whitten

Patisaul

2001

Environ Health Perspect

174

105

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This paper compiles animal and human data on the biologic effects and exposure levels of phytoestrogens in order to identify areas of research in which direct species comparisons can be made. In vitro and in vivo assays of phytoestrogen action and potency are reviewed and compared to actions, dose-response relationships, and estimates of exposure in human subjects. Binding studies show that the isoflavonoid phytoestrogens are high-affinity ligands for estrogen receptors (ERs), especially ER beta, but have lower potency in whole-cell assays, perhaps because of interactions with binding proteins. Many other enzymatic actions require concentrations higher than those normally seen in plasma. In vivo data show that phytoestrogens have a wide range of biologic effects at doses and plasma concentrations seen with normal human diets. Significant in vivoresponses have been observed in animal and human tests for bone, breast, ovary, pituitary, vasculature, prostate, and serum lipids. The doses reported to be biologically active in humans (0.4--10 mg/kg body weight/day) are lower than the doses generally reported to be active in rodents (10--100 mg/kg body weight/day), although some studies have reported rodent responses at lower doses. However, available estimates of bioavailability and peak plasma levels in rodents and humans are more similar. Steroidogenesis and the hypothalamic-pituitary-gonadal axis appear to be important loci of phytoestrogen actions, but these inferences must be tentative because good dose-response data are not available for many end points. The similarity of reported proliferative and antiproliferative doses illustrates the need for fuller examination of dose-response relationships and multiple end points in assessing phytoestrogen actions.

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Phytoestrogens: Adverse Effects on Reproduction in California Quail

Cited by 190 publications

References 7 publications

Effect of Plant Hormone Gibberellic Acid-3 on Rat Testicular Biomarkers and Its Histology

Effect of Plant Hormone Gibberellic Acid-3 on Rat Testicular Biomarkers and Its Histology

Soy, phytoestrogens and their impact on reproductive health

Cross-species and interassay comparisons of phytoestrogen action.

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