Soy, phytoestrogens and their impact on reproductive health

Cederroth, Christopher R.; Zimmermann, Céline; Nef, Serge

doi:10.1016/j.mce.2011.05.049

Cited by 190 publications

(150 citation statements)

References 118 publications

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“…They lead to altered sexual development and reproduction in both sexes of human and wild life animals (1)(2)(3)(4). One of these endocrine disrupting chemicals is Bisphenol A (BPA).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Effects of Bisphenol A on the Histology and Ultrastructure of Prostate and Seminal Vesicle Glands in Rats

Hasanluyi

Khojasteh

Nejhad

2016

Thrita

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Background: Bisphenol A is a xenoestrogen, synthesized in large quantities for the production of polymers (polycarbonates, epoxy resins) and thermal paper, and is widely used in products of everyday use (packaging, containers and bottles). Data concerning the occurrence of BPA in food, water and indoor environments as well as its appearance in tissues and body fluids of the human body are available in the literature. Male accessory sex glands are also vulnerable to environmental endocrine disruptors with adverse effects in adulthood. The developing prostate gland is particularly sensitive to estrogens and high-dose exposures during a critical developmental window results in intraepithelial prostatic neoplasia (PIN) in adult rodent models. Bisphenol A is also an endocrine disruptor. High levels of BPA exposure correlate with increased risk of mammary gland, brain and prostate cancers and have adverse effects on the tissues of the prostate and seminal vesicles. Objectives: The aim of this study was to investigate the effects of BPA doses on the histological structure and ultrastructure of prostate and seminal vesicle glands. Methods: Forty male Wistar rats were randomly divided into four groups (n = 10): A control group and three treatment groups,

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“…They lead to altered sexual development and reproduction in both sexes of human and wild life animals (1)(2)(3)(4). One of these endocrine disrupting chemicals is Bisphenol A (BPA).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Effects of Bisphenol A on the Histology and Ultrastructure of Prostate and Seminal Vesicle Glands in Rats

Hasanluyi

Khojasteh

Nejhad

2016

Thrita

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“…Some EDCs are agonistic ligands that directly bind to hormone receptors, whereas others inhibit receptor functions as antagonists. For example, xenoestrogens such as Bisphenol A (BPA) (1) and genistein (5) are EDCs that activate estrogen receptors by direct binding. Tributyltin is an obesogenic EDC that binds to peroxisome proliferation-activated receptor γ (PPAR-γ) to activate the retinoid X receptor (RXR)-PPAR heterodimer nuclear receptor complex, enhancing adipogenesis (6).…”

mentioning

confidence: 99%

Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes

Shioda

Rosenthal

Coser

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Although biological effects of endocrine disrupting chemicals (EDCs) are often observed at unexpectedly low doses with occasional nonmonotonic dose-response characteristics, transcriptomewide profiles of sensitivities or dose-dependent behaviors of the EDC responsive genes have remained unexplored. Here, we describe expressome analysis for the comprehensive examination of dosedependent gene responses and its applications to characterize estrogen responsive genes in MCF-7 cells. Transcriptomes of MCF-7 cells exposed to varying concentrations of representative natural and xenobiotic estrogens for 48 h were determined by microarray and used for computational calculation of interpolated approximations of estimated transcriptomes for 300 doses uniformly distributed in log space for each chemical. The entire collection of these estimated transcriptomes, designated as the expressome, has provided unique opportunities to profile chemical-specific distributions of ligand sensitivities for large numbers of estrogen responsive genes, revealing that at low concentrations estrogens generally tended to suppress rather than to activate transcription. Gene ontology analysis demonstrated distinct functional enrichment between high-and low-sensitivity estrogen responsive genes, supporting the notion that a single EDC chemical can cause qualitatively distinct biological responses at different doses. Expressomal heatmap visualization of dose-dependent induction of Bisphenol A inducible genes showed a weak gene activation peak at a very low concentration range (ca. 0.1 nM) in addition to the main, strong gene activation peak at and above 100 nM. Thus, expressome analysis is a powerful approach to understanding the EDC dose-dependent dynamic changes in gene expression at the transcriptomal level, providing important information on the overall profiles of ligand sensitivities and nonmonotonic responses.

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“…The shorter AGD may be ascribed to lower androgen function during the hormone-sensitive male programming window [33] or postnatally [34]. Thus, the mixture of the substances used in this study may have had an additive or synergistic effect resulting in a shorter AGD in the mixture-exposed group (group D).…”

Section: Discussionmentioning

confidence: 87%

Effects of environmental endocrine disruptors, including insecticides used for malaria vector control on reproductive parameters of male rats

Patrick

Bornman

Joubert

et al. 2016

Reproductive Toxicology

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The male reproductive system is sensitive to endocrine disrupting chemicals (EDCs) during critical developmental windows. Male Sprague-Dawley rats were exposed in utero-, during lactation-and directly to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and a mixture of DDT, deltamethrin (DM), pnonylphenol (p-NP) and phytoestrogens, at concentrations found in a malaria-area. After dosing for 104 days, histological assessments and reproductive-endpoints were assessed.The anogenital distance (AGD) (P = 0.005) was shorter in the mixture-exposed group, while the prostate mass (P = 0.018) was higher in the DDT-exposed group. A higher testicular mass and abnormal histology was observed in the DDT-(P = 0.019), DDE-(P = 0.047) and mixture-exposed (P < 0.005) groups. This study shows that in utero-, lactational-and direct exposure to EDCs present in a malaria-area negatively affects male reproductive parameters in rats. These findings raise concerns to EDC-exposures to mothers living in malaria-areas and the reproductive health of their male offspring. 1

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Soy, phytoestrogens and their impact on reproductive health

Cited by 190 publications

References 118 publications

Investigation of the Effects of Bisphenol A on the Histology and Ultrastructure of Prostate and Seminal Vesicle Glands in Rats

Investigation of the Effects of Bisphenol A on the Histology and Ultrastructure of Prostate and Seminal Vesicle Glands in Rats

Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes

Effects of environmental endocrine disruptors, including insecticides used for malaria vector control on reproductive parameters of male rats

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