Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare

Abstract

Phytoecdysones from Serratula coronata seem to be promising agents for skincare in patients with psoriasis. The aim of the study was to determine the effects of creams containing the extract of S. coronata on psoriatic lesions. Creams with different formulas were prepared: 0-Lekobaza®, 1-Lekobaza®, S. coronata, 2-Lekobaza®, Salicylic acid, 3-Lekobaza®, S. coronata, Salicylic acid. After examination of skin penetration and biosafety, the designated cream was applied twice daily for 6 weeks on 72 psoriatic plaques located on elbows or knees. The lesions were assessed at baseline and follow-up of 6 weeks. The lesions area was measured, and severity of scaling, erythema, and infiltration was assessed using a 5-point scale (from 0—none to 4—very severe). Skin hydration and structure, pH, transepidermal water loss, erythema, and melanin index were analyzed instrumentally. Creams 1, 2, and 3 significantly reduced the area of psoriatic plaques. Improvement in erythema and infiltration was observed for creams 1 and 3. Creams 1–3 reduced scaling. Our study confirmed a beneficial effect of creams containing S. coronata extract on psoriatic lesions.

Adsorption isotherms and kinetics for Pb(ii) ion removal from aqueous solutions with biogenic metal oxide nanoparticles

“…26 The aerial part (leaves, stems) of SCR, found in Central Kazakhstan (Karaganda region) exhibits a signicant enrichment of various phytoecdysteroids and avonoids. [27][28][29] Notably, the phytoecdysones derived from SCR promise as potential agents for the treatment of different skin diseases, [30][31][32] while avonoids demonstrate noteworthy antioxidant activity. 33 Despite the abundant presence of secondary metabolites in SCR, which are known to be capable of reducing metal ions, this plant remains relatively understudied as a potential precursor for the biogenic synthesis of catalytically active metal oxide nanoparticles.…”

Biological Activities of Natural Products III

“…Kroma A. et al [ 1 ] documented the beneficial effect of creams with ethanolic extract from the herb known as Serratula coronata in the treatment of psoriatic patients. The authors determined the primary group of components of this extract responsible for a significant reduction in the area of psoriatic plagues and improvement in skin conditions was probably ecdysteroids.…”