Phytoconstituents from the root of Streptocaulon tomentosum and their chemotaxonomical relevance for separation from S. juventas

Khine, Myint Myint; Arnold, Norbert; Franke, Katrin; Porzel, Andrea; Schmidt, Jürgen; Wessjohann, Ludger A.

doi:10.1016/j.bse.2007.01.006

Cited by 8 publications

(3 citation statements)

References 19 publications

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“…S. juventas is used to treat acute or chronic enteritis, upper respiratory infection, and acute tonsillitis, suggesting its anti-inflammatory activity. Phytochemical studies have shown that CTSs are the major chemical constituents of this species [10][11][12][13][14]. Using ATPase activity assayguided isolation, we aimed to obtain active structurally diverse CTSs and study their ligand effects through NKA receptor transduction.…”

Section: Bioassay-guided Fractionation and Biological Activity Of Car...mentioning

confidence: 99%

“…[17], glucodigitoxigenin(7) [20], sarmentogenin-3-O-β-D-allopyranoside(8) [21], periplogenin glucoside (9)[22], somalin(11) [23], periplocymarin(12) [9], tupichinolide (13)[24], periplogenin digitoxoside(14) [9], 3-O-(β-glucopyranosyl) acovenosigenin A (15)[13], digitoxigenin gentiobioside(16) [14], 1α,14β-dihydroxy-5β-card-20 (22)-enolide-3-O-[O-β-D-glucopyranosyl-(1 → 2)-β-D-digitalopyranoside] (17) [14], acovenosigenin A 3-O-[O-β-D-glucopyranosyl-(1 → 4)-β-D-digitalopyranoside] (18)[14], griffithigenin(19) [14], and 16-dehydrodigitoxigenin glucoside (20)[14] based on comparison of the NMR data with the literature.The binding of sub-inotropic doses of CTSs, such as ouabain, to NKA results in the transactivation of the epidermal growth factor receptors (EGFRs), resulting in the activation of the MAPK/ERK pathway[5]. In addition, ouabain stimulates phosphoinositide 3kinase (PI3K), resulting in the activation of protein kinase B (Akt) ▶ Fig.2Identified structural formula of CTSs from S. juventas.…”

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confidence: 99%

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Bioassay-Guided Fractionation and Biological Activity of Cardenolides from Streptocaulon juventas

Xu,

Zhu

et al. 2023

Planta Med

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The discovery that Na/K-ATPase acts as a signal transducer led us to investigate the structural diversity of cardiotonic steroids and study their ligand effects. By applying Na/K-ATPase activity assay-guided fractionation, we isolated a total of 20 cardiotonic steroids from Streptocaulon juventas, including an undescribed juventasoside B (10) and 19 known cardiotonic steroids. Their structures have been elucidated. Using our platform of purified Na/K-ATPase and an LLC-PK1 cell model, we found that 10, at a concentration that induces less than 10% Na/K-ATPase inhibition, can stimulate the Na/K-ATPase/Src receptor complex and selectively activate downstream pathways, ultimately altering prostate cancer cell growth. By assessing the ligand effect of the isolated cardiotonic steroids, we found that the regulation of cell viability by the isolated cardiotonic steroids was not associated with their inhibitory potencies against Na/K-ATPase activity but reflected their ligand-binding affinity to the Na/K-ATPase receptor. Based on this discovery, we identified a unique active cardiotonic steroid, digitoxigenin (1), and verified that it can protect LLC-PK1 cells from hypoxic injury, implicating its potential use in ischemia/reperfusion injury and inducing collagen synthesis in primary human dermal fibroblast cells, and implicating that compound 2 is the molecular basis of the wound healing activity of S. juventas.

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Section: Bioassay-guided Fractionation and Biological Activity Of Car...mentioning

confidence: 99%

mentioning

confidence: 99%

Bioassay-Guided Fractionation and Biological Activity of Cardenolides from Streptocaulon juventas

Xu,

Zhu

et al. 2023

Planta Med

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“…Previous studies showed that Sj has antimicrobial activity against Aspergillus niger , Penicillin cyclopium, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa , and Escherichia coli , in vitro antiplasmodial activity, anti‐proliferative activity against some cancer cell lines, and antioxidant activity . The constituents of Sj have been reported to include glycosides, cardenolides, hemiterpenoids, triterpenoids, terpenoids, phenylpropanoids, syringaldehyde, isofraxidin, and ferulic acid . Sj has traditionally been used to treat wounds in the K'Ho minority, Lam Dong Province, Vietnam, but there have been no reports on the plant's wound healing activity.…”

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Wound healing activity of Streptocaulon juventas root ethanolic extract

Nguyen

Kamei

et al. 2017

Wound Repair Regeneration

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Streptocaulon juventas is a well-known plant that has antimicrobial activity, in vitro antiplasmodial activity, anti-proliferative activity, and antioxidant activity. In this study, we showed experimental evidence that proved that S. juventas root ethanolic extract has wound healing activities. First, in a mouse excision wound model, S. juventas root ethanolic extract at a dose of 100 mg/kg/day significantly reduced the wound closure time. After 7 days, the wound granulation tissue in mice treated with the extract exhibited a 2.3-fold decrease in inflammatory cells, a 1.7-fold increase in fibroblasts and enhanced angiogenesis. Molecular analysis also revealed that after wounds were treated with S. juventas root ethanolic extract, TNF-α and NF-κB1 gene expression were down-regulated by 4.7 and 3.7 times, respectively. In contrast, TGF-β1 and VEGF gene expression were up-regulated by 1.9 and 6.5 times, respectively. Taken together, our experimental data strongly show that the ethanolic extract from S. juventas root displays remarkable wound healing activity.

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Bioactive Compounds from Medicinal Plants in Myanmar

Win

Morita

2021

Progress in the Chemistry of Organic Natural Products 114

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Phytoconstituents from the root of Streptocaulon tomentosum and their chemotaxonomical relevance for separation from S. juventas

Cited by 8 publications

References 19 publications

Bioassay-Guided Fractionation and Biological Activity of Cardenolides from Streptocaulon juventas

Bioassay-Guided Fractionation and Biological Activity of Cardenolides from Streptocaulon juventas

Wound healing activity of Streptocaulon juventas root ethanolic extract

Bioactive Compounds from Medicinal Plants in Myanmar

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