Phytoconstituents and Hepatoprotective Effect of Suaeda Monoica Forssk and Suaeda Pruinosa Lange

Abstract

The objective of this study is to investigate the chemical constituents of Suaeda monoica and Suaeda pruinosa and evaluate their effects on rat liver intoxicated by over dose of paracetamol. Qualitative analysis of (80%) methanol in water fraction revealed the presence of alkaloids, terpenoids, steroids, tannins, quinones, saponins, flavonoids and phenols from two mangrove species of S. monoica and S. pruinosa was carried out. The compounds were identified from the 80% methanol-H2O fraction as Rutin, quercetin, Syringic acid, Coffeic acid, Catechin, Coumaric acid, Vanillin, Gallic acid, Cinnamic acid. Amino acids analysis for the methanolic extract from the aerial parts of Suaeda monoica and Suaeda pruinosa showed the presence of thirteen amino acids and absence of valine, Isoleucine, Phenylalanine. Fatty acid analysis of lipids showed high percentage of long chain fatty acids.TLC of the lipoidal matter for each plant showed the presence β-amyrin, β-sitosterol and stigmasterol. Toxicity was stimulated by administration of a single oral dose of paracetamol (3 g/kg body weight). The extract of the aerial parts of plants (100 mg/kg) was utilized on a pre-and post-treatment basis. Both extracts significantly improved liver and kidney function with prophylactic or therapeutic treatments. Histopathological and histochemical studies showed parallel effects with the biochemical measured parameters.

Targeting the PI3K/pAKT/mTOR/NF‐κB/FOXO3a signaling pathway for suppressing the development of hepatocellular carcinoma in rats: Role of the natural remedic Suaeda vermiculata forssk

“…Similar investigations have found that SVE reduces AST and ALT levels elevated by liver damage induced by paracetamol 35 and CCL 4 27 in mouse and rat animal models, respectively. Furthermore, similar hepatoprotective effects have been demonstrated for other Suaeda species, such as S. maritima against concanavalin‐A‐induced hepatotoxicity 50 and S. monoica and S. pruinosa against paracetamol‐induced hepatotoxicity 51 . An earlier study stated that the combination of SVE and doxorubicin showed a synergistic cytotoxic effect against doxorubicin‐resistant HepG‐2 cell carcinoma 27 .…”

“…Furthermore, similar hepatoprotective effects have been demonstrated for other Suaeda species, such as S. maritima against concanavalin-A-induced hepatotoxicity 50 and S. monoica and S. pruinosa against paracetamol-induced hepatotoxicity. 51 An earlier study stated that the combination of SVE and doxorubicin showed a synergistic cytotoxic effect against doxorubicin-resistant HepG-2 cell carcinoma. 27 Herein, we report for the first time a detailed investigation of the in vivo protective effect of SVE against DENA-induced hepatocellular carcinoma (HCC).…”

Anti-inflammatory Properties of Strontium Oxide Nanoparticles Synthesized From Suaeda monoica Saltmarsh

“…They can be found all over the world on saline and alkaline land, as well as in deserts, lakes, and lakeshores. Suaeda monoica possesses anti-inflammatory, hypolipidemic, cardiotonic, antioxidant, antibacterial, and anti-cancer properties [ 14 ]. Suaeda maritima (L) Dumort, Suaeda monoica Forssk.…”