Phytochemistry, Food Application, and Therapeutic Potential of the Medicinal Plant (Withania coagulans): A Review

Khan, Muhammad Issa; Maqsood, Maria; Saeed, Raakia Anam; Alam, Aftab; Sahar, Amna; Kieliszek, Marek; Miecznikowski, A.; Muzammil, Hafiz Shehzad; Aadil, Rana Muhammad

doi:10.3390/molecules26226881

Cited by 44 publications

(39 citation statements)

References 63 publications

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“…Plants have been used to treat and cure a variety of health conditions since ancient times. Ayurvedic medicine is widely used due to its few documented adverse effects and a plethora of benefits [ 13 ]. Although ayurvedic medicine, an ancient style of treatment practised in the Indian subcontinent, is thought to be free of side effects, few clinical cases have reported the likelihood of adverse effects associated with the use of ayurvedic medications, for example, consumption of swarnabhasma (gold salt) in liver disease may worsen the condition and ayurvedic medicine containing reserpine in hypertensive man may pose negative health effects [ 14 ].…”

Section: Jamun Against Metabolic Syndromementioning

confidence: 99%

Astounding Health Benefits of Jamun (Syzygium cumini) toward Metabolic Syndrome

et al. 2022

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Syzygium cumini, also called Jamun, or black plum, is an excellent source of bioactive components such as flavonoids, polyphenols, antioxidants, iron, and vitamin C. The Jamun tree is a tropical evergreen blooming plant and is an important medicinal plant from the Myrtaceae family that has been used for a long time in Indian and other traditional medicines across the world. Jamun is mainly cultivated in Asian countries such as Pakistan, India, Sri Lanka, and Bangladesh. Since ancient medicine, it has been utilized to treat a variety of diseases and physiological conditions. Currently, it is mostly used as a medication to treat various metabolic issues, including diabetes, hyperlipidemia, hypertension, obesity, etc. Therefore, Jamun could serve a beneficial role against metabolic syndrome (MS). In this work, the latest available scientific literature on Jamun was collected and the clinical trials investigating its effect on diabetes, hypertension, obesity, and hyperlipidemia were analyzed to find out how Jamun could improve the symptoms and biomarkers of MS. Overall, the results of this study found a significant association of Jamun with the prevention and treatment of these biomarkers of MS. In many studies, Jamun showed pharmacological modifications not only in MS but in many other diseases as well. Currently, its utilization as a folk medicine for the treatment of patients with MS is widely acknowledged. Hence, the findings of a large number of clinical studies confirmed the ameliorating effects of Jamun against MS due to its antioxidation, antidiabetic, anti-inflammation anticarcinogenic, and hyperlipidemic effects. More research is still needed to determine and identify the Jamun compounds and to elucidate their mechanisms of action that are responsible for these astounding bioactive properties and health benefits.

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Section: Jamun Against Metabolic Syndromementioning

confidence: 99%

Astounding Health Benefits of Jamun (Syzygium cumini) toward Metabolic Syndrome

et al. 2022

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“…These withanolides have also been shown to inhibit tumor necrosis factor-α (TNF-α)-induced nuclear factor-kappa B (NF-κB) activation, with IC 50 values in the range of 8.8–11.8 μM. Moreover, the compounds isolated from W. coagulans , including certain coagulans, coagulanolides, and coagulins isolated from various plant parts, including roots, leaves, and fruits, have been attributed extensive anti-fungal, anti-cytotoxic, anti-diabetic, hypolipidemic, neuroprotective, anti-inflammatory, anti-cancerous, anthelmintic, antioxidant, and wound healing activities [ 87 ].…”

Section: Withanolides As Anti-cancer Agentsmentioning

confidence: 99%

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

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Natural products are a major source of biologically active compounds that make promising lead molecules for developing efficacious drug-like molecules. Natural withanolides are found in many flora and fauna, including plants, algae, and corals, that traditionally have shown multiple health benefits and are known for their anti-cancer, anti-inflammatory, anti-bacterial, anti-leishmaniasis, and many other medicinal properties. Structures of these withanolides possess a few reactive sites that can be exploited to design and synthesize more potent and safe analogs. In this review, we discuss the literature evidence related to the medicinal implications, particularly anticancer properties of natural withanolides and their synthetic analogs, and provide perspectives on the translational potential of these promising compounds.

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“…Withania coagulans is usually known as a cheese maker in the Indian language and paneer in Pakistan because its fruit and leaves have milk-coagulating properties. Withania coagulans has been used in a number of diseases and disorders due to the presence of Withanolides [ 12 ]. Active constituents are Withaferin A, Withanolide , and Coagulins [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Co-Combination of Pregabalin and Withania coagulans-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model

Asghar

Aamir

Sheikh³

et al. 2022

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The current study reports the fabrication of co-combination gel using Pregabalin and Withania coagulans fruit extract to validate its effectiveness for neuropathic pain in chronic constriction injury (CCI) rat models. Three topical gels were prepared using Carbopol 934 through a pseudo-ternary phase diagram incorporating the Pregabalin (2.5%), Withania coagulans extract (2%), and co-combination of both Pregabalin (2.5%) and Withania coagulans extract (2%). Gels were characterized. FTIR showed a successful polymeric network of the gel without any interaction. The drug distribution at the molecular level was confirmed by XRD. The AFM images topographically indicated the rough surface of gels with a size range from 0.25 to 330 nm. DSC showed the disappearance of sharp peaks of the drug and extract, showing successful incorporation into the polymeric network of gels. The in vitro drug release of co-combination gel was 73% over 48 h. The mechanism of drug release by combination gel was Higuchi+ fickian with values of n (0.282) and R2 (0.947). An in vivo study for pain assessment via four methods: (i) heat hyperalgesia, (ii) cold allodynia, (iii) mechano-hyperalgesia, and (iv) dynamic mechano-allodynia, confirmed that topical treatment with co-combination gel reduced the pain significantly as indicated by the p value: R1 (p < 0.001), R2 (p < 0.001), R3 (p < 0.015), and R4 (p < 0.0344). The significance order was R2 (****) > R1 (***) > R3 (**) > R4 (*) > R5 (ns).

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Phytochemistry, Food Application, and Therapeutic Potential of the Medicinal Plant (Withania coagulans): A Review

Cited by 44 publications

References 63 publications

Astounding Health Benefits of Jamun (Syzygium cumini) toward Metabolic Syndrome

Astounding Health Benefits of Jamun (Syzygium cumini) toward Metabolic Syndrome

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

Co-Combination of Pregabalin and Withania coagulans-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model

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