Phytochemistry and pharmacology of Allii Macrostemonis Bulbus, a traditional Chinese medicine

Yao, Zhihong; Qin, Z. H.; Dai, Yi; Yao, Xin‐Sheng

doi:10.1016/s1875-5364(16)30058-9

Cited by 26 publications

(34 citation statements)

References 43 publications

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“…Fei Wei explained that the modal differences have different effects on the listening comprehension at different levels [10]. Yao Wei and Yao Guoqun studied multidimensional autonomous listening and found that modal helped to improve students' ability of multiple reading and understanding [11]. But at present, there is no research on the multi-modal professional English listening teaching, and there is no research paying attention to the effect of concrete modal in professional English listening teaching.…”

Section: Research Backgroundmentioning

confidence: 99%

A Study of Multimodal Effects on ESP Listening Comprehension

Tao¹,

Luo²,

Zhao³

2017

Proceedings of the 2017 7th International Conference on Education, Management, Computer and Society (EMCS 2017)

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Abstract. This study inquires into the effect of multimodality on ESP listening comprehension by examining the students' English summaries of the audiovisual recording material that comprises 51 semantic units. The study objects are 120 randomly chosen pilot cadets, who are split evenly into 4 groups: 1 control group and 3 test groups. For each group, the material is presented three times but with a different combination of multimodal. Then by using SPSS (17.0), single factor ANOVA and Post Hoc multiple tests are applied to analyze the collected data so as to find out effects of multimodality on ESP listening teaching. The study indicates that proper use of multimodality can significantly improve students' listening comprehension and visual modality has to correspond to audio modality information in order to produce desired effects. The study also demonstrates that target language subtitles are more helpful than native ones for listening comprehension.

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Section: Research Backgroundmentioning

confidence: 99%

A Study of Multimodal Effects on ESP Listening Comprehension

Tao¹,

Luo²,

Zhao³

2017

Proceedings of the 2017 7th International Conference on Education, Management, Computer and Society (EMCS 2017)

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“…XZT is synthesized from Allium macrostemon extract. It has proven that Allium macrostemon contains methyl allyl trisulfide, macrostemonoside A and other sulphur compounds, which have the effect of lipid lowering and antiatherosclerosis [8]. The pharmacological action of XZT on the cardiovascular system is to reduce the levels of TC, TG and LDL-C in the blood, increase the level of HDL-C, inhibit the aggregation of platelets and thrombosis, protect against myocardial injury caused by hypoxia ischaemia and ischaemia-reperfusion, and prevent and control atherosclerosis at the same time [21].…”

Section: Discussionmentioning

confidence: 99%

“…Xie Bai is an ancient Chinese medicinal plant that is widely used to treat CVDs in China. Modern pharmacological studies have shown that Allium macrostemon contains a variety of active ingredients, such as methyl allyl trisulfide, saponins, and adenosines [8]. Preliminary studies have proven that XZT can significantly reduce blood lipids, inhibit platelet aggregation, confer anti-thrombosis, and prevent and treat atherosclerosis [9].…”

Section: Introductionmentioning

confidence: 99%

Effects of Xuezhitong in Patients with Hypertriglyceridemia: a Multicentre, Randomized, Double-Blind, Double Simulation, Positive Drug and Placebo Parallel Control Study

Jia

Wan

et al. 2020

Cardiovasc Drugs Ther

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Backgroud Xuezhitong (XZT) is an extract of Allium macrostemon Bunge that has lipid-lowering properties. Objective To evaluate the effects of XZT on lipids in subjects with hypertriglyceridemia (HTG) without severe dyslipidaemia. Methods A total of 358 subjects with HTG were enrolled and randomly assigned to receive XZT (2700 mg daily), xuezhikang (XZK) (1200 mg daily) or placebo. The primary endpoint was the reduction or percent reduction in the TG level over 12 weeks of treatment. Results At the 12-week follow-up, a reduction in the TG level from baseline was observed in both groups, but the XZT and XZK groups demonstrated a significantly greater reduction than the placebo group (30.77%, 24.02% vs 11.59%, P < 0.0167); 70.54% of subjects in the XZT group and 62.30% of subjects in the XZK group demonstrated reductions in TG levels of at least 20%, compared with 41.67% of the subjects in the placebo group (P < 0.0167). Treatment with XZT capsules also demonstrated superior performance compared with the placebo with respect to the control of lipids (17.97% vs 5.00%), total cholesterol (TC) (14.18% vs 3.89%), low-density lipoprotein cholesterol (LDL-C) (17.98% vs 2.95%), and high-density lipoprotein cholesterol (HDL-C) (21.47% vs 2.16%). Daily use of XZT for 12 weeks resulted in statistically significant (65.22% vs 38.30%, 25.00%; P < 0.0167) and clinically meaningful increases in HDL-C levels by ≥4 mg/dl compared with XZK and placebo. XZT was safe and well tolerated; the safety and tolerability profiles were similar across treatment groups. No subject experienced myopathy or markedly elevated liver transaminases or creatine kinase. Conclusions XZT significantly reduced TG levels and was well tolerated. Longer-term studies in more diverse patient populations are needed to corroborate these findings. Clinical Trial Registration www.chictr.org.cn Identifier: ChiCTR1900025854.

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“…GLXB is known to contain a range of chemicals including the 10 compounds identified in the present study which belong to nitrogenous compounds and steroidal saponins. Of the 10 compounds, adenosine has been approved by the FDA in 1989 for the treatment of arrhythmias, adenosine, 2,3,4,9-tetrahydro-1H-pyrido [3,4-b] indole-3 R carboxylic acid and 2,3,4,9-tetrahydro-1H-pyrido [3,4-b] indole-3 S carboxylic acid have been shown to inhibit human platelet aggregation activity, anti-inflammatory and anti-procoagulant activity (Wang et al, 2016 ; Yao et al, 2016 ). However, none of them is known capable of mediating energy metabolism.…”

Section: Discussionmentioning

confidence: 99%

Gualou Xiebai Decoction, a Traditional Chinese Medicine, Prevents Cardiac Reperfusion Injury of Hyperlipidemia Rat via Energy Modulation

et al. 2018

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Background: Gualou Xiebai Decoction (GLXB) is a classic prescription of Chinese medicine used for the treatment of cardiac problems. The present study was designed to explore the effect and mechanism of GLXB on ischemia/reperfusion (I/R) induced disorders in myocardial structure and function, focusing on the regulation of energy metabolism and the RhoA/ROCK pathway.Methods: After hyperlipidemic rat model was established by oral administration of high fat diet, the rats were treated with GLXB for 6 weeks and subjected to 30 min occlusion of the left anterior descending coronary artery (LADCA) followed by 90 min reperfusion to elicit I/R challenge. Myocardial infarct size was assessed by Evans blue-TTC staining. Myocardial blood flow (MBF) and cardiac function were evaluated. Enzyme-linked immunosorbent assay was performed to examine the content of ATP, ADP, AMP, CK, CK-MB, LDH, cTnT, cTnI, and IL-6. Double staining of F-actin and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling was conducted to assess myocardial apoptosis. Expressions of ATP synthase subunit δ (ATP 5D), and RhoA and ROCK were determined by Western blotting.Results: Administration with GLXB at high dose for 6 weeks protected heart against I/R-induced MBF decrease, myocardial infarction and apoptosis, ameliorated I/R-caused impairment of cardiac function and myocardial structure, restored the decrease in the ratio of ADP/ATP and AMP/ATP, and the expression of ATP 5D with inhibiting the expression of RhoA and ROCK.Conclusions: Treatment with GLXB effectively protects myocardial structure and function from I/R challenge, possibly via regulating energy metabolism involving inactivation of RhoA/ROCK signaling pathway.

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Phytochemistry and pharmacology of Allii Macrostemonis Bulbus, a traditional Chinese medicine

Cited by 26 publications

References 43 publications

A Study of Multimodal Effects on ESP Listening Comprehension

A Study of Multimodal Effects on ESP Listening Comprehension

Effects of Xuezhitong in Patients with Hypertriglyceridemia: a Multicentre, Randomized, Double-Blind, Double Simulation, Positive Drug and Placebo Parallel Control Study

Gualou Xiebai Decoction, a Traditional Chinese Medicine, Prevents Cardiac Reperfusion Injury of Hyperlipidemia Rat via Energy Modulation

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