Phytochemicals: Potential Therapeutic Modulators of Radiation Induced Signaling Pathways

Jit, Bimal Prasad; Pradhan, Biswajita; Dash, Rutumbara; Bhuyan, Prajna Paramita; Behera, Chhandashree; Behera, Ratikanta; Sharma, Ashok; Baños, Miguel Alcaraz; Jena, Mrutyunjay

doi:10.3390/antiox11010049

Cited by 19 publications

(11 citation statements)

References 169 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Xanthine oxidase and lipoxygenase are inhibited by many polyphenols, thus reducing the generation of free radicals. Finally, many polyphenols decrease the activation of NF-κB and MAPK, thus reducing the release of inflammatory cytokines which play a role in the radiation-induced inflammatory response [ 102 , 103 , 104 ].…”

Section: Medical Countermeasuresmentioning

confidence: 99%

See 1 more Smart Citation

Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry

et al. 2022

View full text Add to dashboard Cite

Atomic and radiological crises can be caused by accidents, military activities, terrorist assaults involving atomic installations, the explosion of nuclear devices, or the utilization of concealed radiation exposure devices. Direct damage is caused when radiation interacts directly with cellular components. Indirect effects are mainly caused by the generation of reactive oxygen species due to radiolysis of water molecules. Acute and persistent oxidative stress associates to radiation-induced biological damages. Biological impacts of atomic radiation exposure can be deterministic (in a period range a posteriori of the event and because of destructive tissue/organ harm) or stochastic (irregular, for example cell mutation related pathologies and heritable infections). Potential countermeasures according to a specific scenario require considering basic issues, e.g., the type of radiation, people directly affected and first responders, range of doses received and whether the exposure or contamination has affected the total body or is partial. This review focuses on available medical countermeasures (radioprotectors, radiomitigators, radionuclide scavengers), biodosimetry (biological and biophysical techniques that can be quantitatively correlated with the magnitude of the radiation dose received), and strategies to implement the response to an accidental radiation exposure. In the case of large-scale atomic or radiological events, the most ideal choice for triage, dose assessment and victim classification, is the utilization of global biodosimetry networks, in combination with the automation of strategies based on modular platforms.

show abstract

Section: Medical Countermeasuresmentioning

confidence: 99%

“…Dietary sources of phytochemicals mentioned in this article and their radioprotective properties are detailed and reviewed in [ 102 , 103 , 104 , 164 ].…”

Section: Medical Countermeasuresmentioning

confidence: 99%

Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Searching of natural compounds in disease various prevention is most promising [114][115][116][117][118][119][120][121]. In this regard, phytoplankton are gaining much attention [122].…”

Section: Phytoplankton Toxin and Their Disease Preventing Activitiesmentioning

confidence: 99%

Toxic Effects and Tumor Promotion Activity of Marine Phytoplankton Toxins: A Review

Pradhan

Kim

Abassi

et al. 2022

Toxins

Self Cite

View full text Add to dashboard Cite

Phytoplankton are photosynthetic microorganisms in aquatic environments that produce many bioactive substances. However, some of them are toxic to aquatic organisms via filter-feeding and are even poisonous to humans through the food chain. Human poisoning from these substances and their serious long-term consequences have resulted in several health threats, including cancer, skin disorders, and other diseases, which have been frequently documented. Seafood poisoning disorders triggered by phytoplankton toxins include paralytic shellfish poisoning (PSP), neurotoxic shellfish poisoning (NSP), amnesic shellfish poisoning (ASP), diarrheic shellfish poisoning (DSP), ciguatera fish poisoning (CFP), and azaspiracid shellfish poisoning (AZP). Accordingly, identifying harmful shellfish poisoning and toxin-producing species and their detrimental effects is urgently required. Although the harmful effects of these toxins are well documented, their possible modes of action are insufficiently understood in terms of clinical symptoms. In this review, we summarize the current state of knowledge regarding phytoplankton toxins and their detrimental consequences, including tumor-promoting activity. The structure, source, and clinical symptoms caused by these toxins, as well as their molecular mechanisms of action on voltage-gated ion channels, are briefly discussed. Moreover, the possible stress-associated reactive oxygen species (ROS)-related modes of action are summarized. Finally, we describe the toxic effects of phytoplankton toxins and discuss future research in the field of stress-associated ROS-related toxicity. Moreover, these toxins can also be used in different pharmacological prospects and can be established as a potent pharmacophore in the near future.

show abstract

“…In the case of low dose radiation exposures, cancer, cardiovascular disease, foetal abnormality, and chronic fatigue are examples of gross adverse effects [ 89 ]. These are thought to result from genomic instability, mutation in critical genes, microenvironment alterations leading to niche compromise, haematological insufficiency and immune dysfunction [ 7 , 29 , 90 , 91 , 92 , 93 , 94 , 95 , 96 ]. These in turn are attributed to DNA damage, elevated ROS, mitochondrial insufficiency, membrane channel imbalances and failure of “checks and balances” on the rate of specific enzyme reactions, leading to tipping points where metabolic malfunction occurs.…”

Section: Downstream Events—the Role Of Ribe and Rigimentioning

confidence: 99%

Low Dose and Non-Targeted Radiation Effects in Environmental Protection and Medicine—A New Model Focusing on Electromagnetic Signaling

Mothersill

Cocchetto

Seymour

2022

IJMS

View full text Add to dashboard Cite

The role of signalling in initiating and perpetuating effects triggered by deposition of ionising radiation energy in parts of a system is very clear. Less clear are the very early steps involved in converting energy to chemical and biological effects in non-targeted parts of the system. The paper aims to present a new model, which could aid our understanding of the role of low dose effects in determining ultimate disease outcomes. We propose a key role for electromagnetic signals resulting from physico-chemical processes such as excitation decay, and acoustic waves. These lead to the initiation of damage response pathways such as elevation of reactive oxygen species and membrane associated changes in key ion channels. Critically, these signalling pathways allow coordination of responses across system levels. For example, depending on how these perturbations are transduced, adverse or beneficial outcomes may predominate. We suggest that by appreciating the importance of signalling and communication between multiple levels of organisation, a unified theory could emerge. This would allow the development of models incorporating time, space and system level to position data in appropriate areas of a multidimensional domain. We propose the use of the term “infosome” to capture the nature of radiation-induced communication systems which include physical as well as chemical signals. We have named our model “the variable response model” or “VRM” which allows for multiple outcomes following exposure to low doses or to signals from low dose irradiated cells, tissues or organisms. We suggest that the use of both dose and infosome in radiation protection might open up new conceptual avenues that could allow intrinsic uncertainty to be embraced within a holistic protection framework.

show abstract

Phytochemicals: Potential Therapeutic Modulators of Radiation Induced Signaling Pathways

Cited by 19 publications

References 169 publications

Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry

Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry

Toxic Effects and Tumor Promotion Activity of Marine Phytoplankton Toxins: A Review

Low Dose and Non-Targeted Radiation Effects in Environmental Protection and Medicine—A New Model Focusing on Electromagnetic Signaling

Contact Info

Product

Resources

About