Phytochemicals mediated modulation of <scp>microRNAs</scp> and long non‐coding <scp>RNAs</scp> in cancer prevention and therapy

Ruiz‐Manriquez, Luis M.; Estrada-Meza, Carolina; Benavides‐Aguilar, Javier A.; Ledesma-Pacheco, S. Janin; Torres-Copado, Andrea; Serrano-Cano, Francisco I; Bandyopadhyay, Anindya; Pathak, Surajit; Chakraborty, Samik; Srivastava, Aashish; Sharma, Ashutosh; Paul, Sujay

doi:10.1002/ptr.7338

Cited by 28 publications

(16 citation statements)

References 180 publications

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“…There is increasing evidence indicating that phytochemicals show great roles in the prevention and treatment of cancer through their modulatory effects on non-coding RNAs ( Ruiz‐Manriquez et al, 2021 ). Curcumin, a major phytochemical in turmeric, has been shown to have an important role in inhibiting proliferation of solid cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429

Wang

Geng

et al. 2022

Front. Genet.

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Platinum-based cytotoxic chemotherapy is considered the standard treatment for advanced gastric cancer (GC). However, cisplatin chemoresistance often occurs with the mechanisms being not well clarified, which results in the cancer recurrence and poor survival. Ginsenoside Rg3, isolated from the Chinese Herb Panax Ginseng, is recognized as an anti-cancer agent. Herein, we aimed to reveal whether Ginsenoside Rg3 alleviates cisplatin resistance and sensitizes GC cells to cisplatin-induced apoptosis, and draw out the underlying molecular mechanism in cisplatin-resistant GC cells. The lower expression of miR-429 was found in AGSR-CDDP cells; it was also in association with cisplatin-resistance in GC cells and expression of which was restored following Ginsenoside Rg3 treatment. We also demonstrated that miR-429 made a contribution toward chemosensitivity in GC cells partly through SOX2 regulation. SOX2 was found to contribute to developing platinum resistance and was an authentic target for miR-429 in AGSR-CDDP cells. Importantly, enforced expression of SOX2 with a pcDNA3-SOX2 construct lacking the 3′-UTR miRNA binding site diminished the cytotoxic effects of miR-429 in AGSR-CDDP cells. We demonstrated that Ginsenoside Rg3 enhanced chemosensitivity in AGSR-CDDP GC cells, at least in part, through up-regulating miR-429, thereby targeting SOX2 and modulating downstream PI3K/AKT/mTOR signaling. Ginsenoside Rg3 was also found to regulate apoptosis-related genes via miR-429 in cisplatin-resistant GC cells. Ginsenoside Rg3 treatment significantly suppressed the migration rate of AGSR-CDDP GC cells, while following transfection with anti-miR-429, the anti-migratory effects of Ginsenoside Rg3 was partially abolished. This data suggested that Ginsenoside Rg3 may impede the chemoresistance and migration of GC cells mainly mediated through miR-429. We concluded that miR-429-regulated SOX2 expression was one of the main mechanisms by which Ginsenoside Rg3 dramatically promoted its anticancer effects on cisplatin-resistant GC cells. We also underscored a supporting model in which miR-429 adjusted PI3K/AKT/mTOR signaling by regulating SOX2 in cisplatin-resistant GC cells.

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Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429

Wang

Geng

et al. 2022

Front. Genet.

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“…Research to date suggests that phytochemicals can drastically alter a number of miRNAs linked to cancer, hence preventing the onset and progression of cancer [ 79 ]. Luteolin-mediated control of miRNAs is an intriguing and growing field.…”

Section: Mechanistic Insight Into the Anticancer Activity Of Luteolinmentioning

confidence: 99%

Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives

Tuli

Rath

Chauhan

et al. 2022

Cancers

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Increasing rates of cancer incidence and the toxicity concerns of existing chemotherapeutic agents have intensified the research to explore more alternative routes to combat tumor. Luteolin, a flavone found in numerous fruits, vegetables, and herbs, has exhibited a number of biological activities, such as anticancer and anti-inflammatory. Luteolin inhibits tumor growth by targeting cellular processes such as apoptosis, cell-cycle progression, angiogenesis and migration. Mechanistically, luteolin causes cell death by downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, Bcl-2, and Bcl-xL, while upregulating BAX, caspase-3, and p21. It has also been reported to inhibit STAT3 signaling by the suppression of STAT3 activation and enhanced STAT3 protein degradation in various cancer cells. Therefore, extensive studies on the anticancer properties of luteolin reveal its promising role in chemoprevention. The present review describes all the possible cellular interactions of luteolin in cancer, along with its synergistic mode of action and nanodelivery insight.

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“…Next, a helicase separates the duplex so that the guide strand can be integrated into the RNA-induced silencing complex, also known as RISC, which is guided by the AGO2 protein. Finally, the RISC-miRNA complex identifies specific mRNA targets by base complementarity leading to translational inhibition or mRNA degradation ( Paul et al, 2021 ; Ruiz-Manriquez et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential

et al. 2023

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MicroRNAs (miRNAs) are small endogenous non-coding RNA molecules capable of regulating gene expression at the post-transcriptional level either by translational inhibition or mRNA degradation and have recently been importantly related to the diagnosis and prognosis of the most relevant endocrine disorders. The endocrine system comprises various highly vascularized ductless organs regulating metabolism, growth and development, and sexual function. Endocrine disorders constitute the fifth principal cause of death worldwide, and they are considered a significant public health problem due to their long-term effects and negative impact on the patient’s quality of life. Over the last few years, miRNAs have been discovered to regulate various biological processes associated with endocrine disorders, which could be advantageous in developing new diagnostic and therapeutic tools. The present review aims to provide an overview of the most recent and significant information regarding the regulatory mechanism of miRNAs during the development of the most relevant endocrine disorders, including diabetes mellitus, thyroid diseases, osteoporosis, pituitary tumors, Cushing’s syndrome, adrenal insufficiency and multiple endocrine neoplasia, and their potential implications as disease biomarkers.

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Phytochemicals mediated modulation of microRNAs and long non‐coding RNAs in cancer prevention and therapy

Cited by 28 publications

References 180 publications

Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429

Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429

Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives

Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential

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