Phytochemicals, Antioxidant Profile and GC-MS Analysis of Ethanol Extract of Simarouba glauca Seeds

Haleshappa, R; Patil, Sharangouda J.; Usha, Talambedu; Murthy, K. S. Anantha

doi:10.5530/ajbls.2020.9.57

Cited by 4 publications

(1 citation statement)

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“…It can be detected by a rise in the absorbance of the reaction mixture as the reducing power rises. Reductants have an antioxidant effect by breaking the free radical chain by donating a hydrogen atom (25). The antioxidant activity of phenolic compounds is mostly owing to their redox characteristics, which can aid in the absorption and neutralization of free radicals, as well as the quenching and decomposition of singlet and triplet oxygen and peroxides (26).…”

Section: Discussionmentioning

confidence: 99%

In vitro antioxidant and antifungal activity of methanol root extract of Flacourtia indica (Burm.f.) Merr. against selected fungal species

Eramma¹,

Gayathri²

2021

Biomedicine

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Introduction and Aim: Flacourtia indica (Burm.f.) Merr. is a member of the family Flacourtiaceae. This herb was used to treat a range of ailments and served as the foundation for ethnomedicine. Despite its enormous medical importance, the plant has received very little research with only a few antibacterial and pharmacological studies. The plant's roots, in particular, are understudied. In this study, the antioxidant and antifungal activities of methanol (MeOH) root extract of F. indica was tested in vitro. Materials and Methods: Antifungal activity was assessed against human fungal pathogens, Aspergillus niger (MTCC 404) and Trichophyton mentagrophytes (MTCC 7687). The natural antioxidants in roots were studied using five different antioxidant methods, including 2, 2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide scavenging (NOS), reducing power assay (RPA), measuring total phenolic content (TPC) by Folin-Ciocalteu Reagent (FCR). Results: When compared to Aspergillus niger, the root extract has strong antifungal activity against Trichophyton mentagrophytes (MTCC 7687), generating a broader zone of inhibition (MTCC 404). Clotrimazole is a common antifungal medicine that can be used as a positive control in this investigation. The antioxidant activity of MeOH root extract increased in a dose-dependent manner, and it had outstanding NOS and antioxidant properties. Conclusion: The results conclude that, F. indica appears to be a promising herbal option for the treatment of a variety of fungal and bacterial infections, with high antioxidant capacity.

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Section: Discussionmentioning

confidence: 99%