Phytochemicals, Antioxidant, Anti-inflammatory Studies, and Identification of Bioactive Compounds Using GC–MS of Ethanolic Novel Polyherbal Extract

Singh, Amit; Kumar, Pradeep; Rajput, Vishnu D.; Mishra, Sunil Kumar; Tiwari, Kavindra Nath; Singh, Anand Kumar; Minkina, Tatiana; Pandey, Ajay Kumar

doi:10.1007/s12010-023-04363-7

Cited by 6 publications

(3 citation statements)

References 91 publications

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“…These compounds exhibit a broad spectrum of bioactive properties, demonstrating their potential therapeutic applications. They include anti-inflammatory [ 13 ], antidiabetic [ 14 ], antiproliferative [ 2 , 15 ], anticancer [ 5 , 15 , 16 ], antimicrobial [ 17 , 18 ], antiprotozoal [ 19 ], antioxidant [ 20 ], antihyperlipidemic [ 2 ], antiasthmatic, and anti-obesity effects [ 21 ]. Additionally, they have beneficial effects on the cardiovascular system, acting as anti-arrhythmic and antihypertensive agents [ 22 ], as well as providing cardioprotective benefits [ 23 ].…”

Section: Sources Of Natural Productsmentioning

confidence: 99%

Aptamers for the Delivery of Plant-Based Compounds: A Review

Gamboa,

Lourenço,

Cruz

et al. 2024

Pharmaceutics

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Natural compounds have a high potential for the treatment of various conditions, including infections, inflammatory diseases, and cancer. However, they usually present poor pharmacokinetics, low specificity, and even toxicity, which limits their use. Therefore, targeted drug delivery systems, typically composed of a carrier and a targeting ligand, can enhance natural product selectivity and effectiveness. Notably, aptamers—short RNA or single-stranded DNA molecules—have gained attention as promising ligands in targeted drug delivery since they are simple to synthesize and modify, and they present high tissue permeability, stability, and a wide array of available targets. The combination of natural products, namely plant-based compounds, with a drug delivery system utilizing aptamers as targeting agents represents an emerging strategy that has the potential to broaden its applications. This review discusses the potential of aptamers as targeting agents in the delivery of natural compounds, as well as new trends and developments in their utilization in the field of medicine.

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Section: Sources Of Natural Productsmentioning

confidence: 99%

Aptamers for the Delivery of Plant-Based Compounds: A Review

Gamboa,

Lourenço,

Cruz

et al. 2024

Pharmaceutics

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“…This compound, also known as myristic acid, can potentially be used as soap and cosmetic ingredients (Becker et al 2010). Another interesting compound was neophytadiene, which is known for its potential anti-inflammatory and antibacterial activities (Kaur et al 2023;Singh et al 2023;Toh et al 2023). The Gracilaria species, G. edulis is an economically important commercial seaweed in Philippine, China, and India.…”

Section: Gcms Analysesmentioning

confidence: 99%

Evaluation of bioprospecting potential of epiphytic Gracilaria edulis harvested from seaweed farm in Seriwe Bay, Lombok, Indonesia

PRASEDYA,

FITRIANI,

SARASWATI

et al. 2023

Biodiversitas

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Abstract. Prasedya ES, Fitriani F, Saraswati PBA, Haqiqi N, Qoriasmadillah W, Hikmaturrohmi H, Nurhidayati SZ, Ariati PEP. 2023. Evaluation of bioprospecting potential of epiphytic Gracilaria edulis harvested from seaweed farm in Seriwe Bay, Lombok, Indonesia. Biodiversitas 24: 5343-5351. The seaweed industry is strategically important in Indonesia, comprising over 40% of the nation's aquaculture annual production. Despite the industry's promising growth, various challenges and problems remain, including intense epiphyte infestation. Hence, investigating the economic value of these epiphytes could provide new opportunities for potential industrial applications. Epiphytic algae is commonly found growing on commercial seaweeds which causes decreased biomass and increased risk of crop failure. Information regarding these epiphytic algae remains limited. This study investigates the molecular identification of the abundant epiphytic macroalgae found in one of the largest seaweed farms in, Seriwe Bay, Lombok, Indonesia. In addition, the epiphytic bioactive activity is also evaluated for further industrial potential. Molecular identification with the mitochondrial marker COX1 identifies the epiphytic macroalgae as Gracilaria edulis (S.G.Gmel.) P.C.Silva. The Indonesian G. edulis is closely related to the G. edulis specimens from Malaysia (JQ026083.1), Philippines (KY995636.1 and KY995635.1), and Thailand (JQ026088.1). The outgroup used was the G. edulis specimen from India (KP099563.1) because it shows the most distinct relationship to the other specimens. Extracted agar of Seriwe G. edulis shows moderate yield (21%) and low gel strength (134 g/cm2). The phytochemical content analyses show that G. edulis agar has a TPC value of 3.65 ± 0.52 mg GAE/g and promising antioxidant activity (DPPH IC50 = 797.40 ± 1.50 µg/mL; ABTS IC50 = 558.40 ± 1.44 µg/mL). Further phytochemical profiling with GCMS shows various promising major constituents such as tetradecanoic acid, neophyte diene, pentadecanoic acid, and hexadecanoic acid. Therefore, the findings suggest that G. edulis displays potential applications in the functional food and cosmetic industry.

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“…The hydroethanolic extract in the investigation at 1000 mg/kg body weight showed a superior analgesic effect to that of the other three extracts [3]. A computational study also showed that the phytochemicals significantly interacted with the Janus kinase (JAK) enzymes involved in rheumatoid arthritis [4]. Viral illnesses like polio, mumps, acquired immunodeficiency syndrome (AIDS), severe acute respiratory syndrome (SARS), encephalitis, measles, Middle East respiratory syndrome (MERS), dengue fever, chikungunya fever, influenza, and coronavirus disease 2019 (COVID-19) have historically caused significant suffering in humans.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Antiviral Properties of Nyctanthes arbor-tristis Linn against the Ebola, SARS-CoV-2, Nipah, and Chikungunya Viruses: A Computational Simulation Study

Albiheyri,

Ahmad,

Khan

et al. 2024

Pharmaceuticals

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Background: The hunt for naturally occurring antiviral compounds to combat viral infection was expedited when COVID-19 and Ebola spread rapidly. Phytochemicals from Nyctanthes arbor-tristis Linn were evaluated as significant inhibitors of these viruses. Methods: Computational tools and techniques were used to assess the binding pattern of phytochemicals from Nyctanthes arbor-tristis Linn to Ebola virus VP35, SARS-CoV-2 protease, Nipah virus glycoprotein, and chikungunya virus. Results: Virtual screening and AutoDock analysis revealed that arborside-C, beta amyrin, and beta-sitosterol exhibited a substantial binding affinity for specific viral targets. The arborside-C and beta-sitosterol molecules were shown to have binding energies of −8.65 and −9.11 kcal/mol, respectively, when interacting with the major protease. Simultaneously, the medication remdesivir exhibited a control value of −6.18 kcal/mol. The measured affinity of phytochemicals for the other investigated targets was −7.52 for beta-amyrin against Ebola and −6.33 kcal/mol for nicotiflorin against Nipah virus targets. Additional molecular dynamics simulation (MDS) conducted on the molecules with significant antiviral potential, specifically the beta-amyrin-VP35 complex showing a stable RMSD pattern, yielded encouraging outcomes. Conclusions: Arborside-C, beta-sitosterol, beta-amyrin, and nicotiflorin could be established as excellent natural antiviral compounds derived from Nyctanthes arbor-tristis Linn. The virus-suppressing phytochemicals in this plant make it a compelling target for both in vitro and in vivo research in the future.

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Phytochemicals, Antioxidant, Anti-inflammatory Studies, and Identification of Bioactive Compounds Using GC–MS of Ethanolic Novel Polyherbal Extract

Cited by 6 publications

References 91 publications

Aptamers for the Delivery of Plant-Based Compounds: A Review

Aptamers for the Delivery of Plant-Based Compounds: A Review

Evaluation of bioprospecting potential of epiphytic Gracilaria edulis harvested from seaweed farm in Seriwe Bay, Lombok, Indonesia

Investigating the Antiviral Properties of Nyctanthes arbor-tristis Linn against the Ebola, SARS-CoV-2, Nipah, and Chikungunya Viruses: A Computational Simulation Study

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