Phytochemicals, antioxidant, and antityrosinase activities of <i>Achillea sivasica</i> Çelik and Akpulat

Haliloglu, Yesim; Özek, Temel; Tekin, Mehmet; Göğer, Fatih; Başer, Kemal Hüsnü Can; Özek, Gülmira

doi:10.1080/10942912.2017.1308954

Cited by 19 publications

(13 citation statements)

References 86 publications

(77 reference statements)

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“…This fact supports the utilization of apigenin rich source in folk medicine for the treatment of DM 69,70 . The methanolic leaf extract of Achillea sivasica presented most potent antioxidant properties with IC 50 0.22 μg/mL, probably because of the highest phenolic and flavonoid contents including apigenin-C-hexoside-C-pentoside, apigenin-C-hexoside-C-hexoside, apigenin-8-C-glucoside, coumaric acid hexoside derivative and so forth 71 .…”

Section: Uhplc-q-tof-ms/ms Analysis Uhplc-qtof-ms/ms Was Used For Mementioning

confidence: 99%

UHPLC-QTOF-MS/MS based phytochemical characterization and anti-hyperglycemic prospective of hydro-ethanolic leaf extract of Butea monosperma

Farooq

Mumtaz

Mukhtar

et al. 2020

Sci Rep

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Butea monosperma is one of the extensively used plants in traditional system of medicines for many therapeutic purposes. in this study, the antioxidant activity, α-glucosidase and α-amylase inhibition properties of freeze drying assisted ultrasonicated leaf extracts (hydro-ethanolic) of B. monosperma have been investigated. The findings revealed that 60% ethanolic fraction exhibited high phenolic contents, total flavonoid contents, highest antioxidant activity, and promising α-glucosidase and αamylase inhibitions. the UHpLc-Qtof-MS/MS analysis indicated the presence of notable metabolites of significant medicinal potential including apigenin, apigenin C-hexoside C-pentoside, apigenin Chexoside C-hexoside, apigenin-6,8-di-C-pentoside and genistin etc., in B. monosperma leave extract. Docking studies were carried out to determine the possible role of each phytochemical present in leaf extract. Binding affinity data and interaction pattern of all the possible phytochemicals in leaf extract of B. monosperma revealed that they can inhibit α-amylase and α-glucosidase synergistically to prevent hyperglycemia. Diabetes mellitus [DM] is most rapidly growing metabolic disorder in the world. It is primarily characterized by hyperglycemia which is associated with disturbed metabolism of carbohydrates, proteins and fats. Such metabolic dysfunctions at physiological level are known to cause detrimental health disorders which lead towards sickness and eventually death 1. According to WHO (World Health Organization), it is estimated that this chronic disease has affected nearly 150 million people throughout the world. This number will increase to three hundred million people or more up to 2025 2. The DM type II (DMT-II) is the most abundant form of diabetes and generally involves the phenomenon of insulin insensitivity or low insulin production. The main reasons behind the spread of this global health problem are mainly modern life style, obesity and consumption of high caloric diet. The growing rate of DM in Asian and African countries is two to three times more than the present rate in other countries 3. The role of reactive oxygen species (ROS) is very crucial in DMT-II pathogenesis. The ROS are produced because of electron transfer to oxygen from mitochondrial metabolic activity. The ROS are captured by antioxidants to maintain the redox homeostasis. However, over production or long-time exposure to ROS may create imbalance which further leads to state of oxidative stress. The oxidative stress exerts harmful impacts on bio-molecules to create metabolic dysfunction. The ROS under umbrella of oxidative stress disturbs the structure based activity of antioxidant enzymes to reduce the antioxidant potential of body 4. The ROS are also involved in impaired insulin secretion from pancreas probably due to dysfunction in β-cells 5. The elevated blood glucose level alters the normal functions of proteins through the process of glycation. The role of glycated end products is obvious in health deterioration and their long term existence...

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Section: Uhplc-q-tof-ms/ms Analysis Uhplc-qtof-ms/ms Was Used For Mementioning

confidence: 99%

UHPLC-QTOF-MS/MS based phytochemical characterization and anti-hyperglycemic prospective of hydro-ethanolic leaf extract of Butea monosperma

Farooq

Mumtaz

Mukhtar

et al. 2020

Sci Rep

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“…amani [46] Artecanin T. parthenifolium [47] Canin T. macrophillum [48] Apigenin T. albipannosum [49] Luteolin T. cinerariifolium [50] Hispidulin T. sibiricum [51] Quercetin T. vulgare T. vulgare [52] Axillarin Naringenin T. sibiricum [53] Table 5 and according to previously published procedure. [55] Detailed description of phenolic compounds identification together with spectral data is given in the supplementary material.…”

Section: Compound Species Ref Dentatin Amentioning

confidence: 99%

Composition and potential of Tanacetum haussknechtii Bornm. Grierson as antioxidant and inhibitor of acetylcholinesterase, tyrosinase, and α-amylase enzymes

Yur

Tekin

Göğer

et al. 2017

International Journal of Food Properties

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The phytochemical composition of essential oils and extracts of Tanacetum haussknechtii were investigated with GC-FID-MS and LC-MS/MS techniques and evaluated against oxidation, acetylcholinesterase, tyrosinase, and α-amylase enzymes. The major volatile constituents of T. haussknectii were found to be αand β-pinene, and borneol. Caffeoylquinic acid derivatives and flavonoids were detected in the aqueous, alcohol, and ethyl acetate extracts. In DPPH assay, the methanol extracts exhibited the highest activity. TEAC assay resulted with superiority of all methanol and the capitula ethyl acetate extract. In β-carotene bleaching assay, linoleic acid was the best protected by the ethyl acetate extract of flower. The flower oil inhibited higher acetylcholinesterase activity than the remaining extracts. The flower ethyl acetate extract was found as the most effective inhibitor of α-amylase. The herb and the leaf+stem water extracts possess highest inhibitory effect on tyrosinase. ARTICLE HISTORY

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“…Researchers around the world take attempts to identify such inhibitors from plant sources considering their less toxicity and better bioavailability for food applications [6,14]. Most researchers focus on identifying plant extracts with antityrosinase activity without understanding which compounds are associated to this effect [15,16]. However, only few papers report their chemical composition [16].…”

Section: Introductionmentioning

confidence: 99%

“…Most researchers focus on identifying plant extracts with antityrosinase activity without understanding which compounds are associated to this effect [15,16]. However, only few papers report their chemical composition [16]. It is well known that phenolic and triterpenoid compounds are the most bioactive compounds that are able to inhibit the tyrosinase enzymatic activity [6].…”

Section: Introductionmentioning

confidence: 99%

Antityrosinase Activity of Combretum micranthum, Euphorbia hirta and Anacardium occidentale Plants: Ultrasound Assisted Extraction Optimization and Profiling of Associated Predominant Metabolites

et al. 2020

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Tyrosinase is an important component of the enzyme polyphenol oxidase, which upon contact with the phenolic substrates forms the pigment melanin and induces undesirable food browning. The phenolic and triterpenoid compounds that naturally occur in plants are well known as tyrosinase inhibitors. Combretum micranthum (CM) leaves, Euphorbia hirta (EH) plant, and Anacardium occidentale (AO) fruits are traditionally known to have potential anti-tyrosinase activities. The aim of this study was to optimize the ultrasound-assisted extraction of secondary metabolites from these matrices, and to evaluate in tubo the antityrosinase activity of these extracts. Efforts were also taken to profile the secondary metabolites, mainly the phenolic and triterpenoid compounds, in order to understand their probable association with tyrosinase inhibition. The optimal ultrasound-assisted extraction conditions for simultaneous extraction of phenolic, and triterpenoid compounds were determined. The aqueous fraction of these extracts showed significant antityrosinase activity, with the CM leaves exhibiting the strongest inhibitory effect (IC50 of 0.58 g·L−1). The predominant metabolic compounds from these natural extracts were putatively identified by using a high-resolution quadrupole-time of flight (QToF) LC-MS instrument. The high-resolution accurate mass-based screening resulted in identification of 88 predominant metabolites, which included dihydrodaidzein-7-O-glucuronide, micromeric acid, syringic acid, morin, quercetin-3-O-(6″-malonyl-glucoside), 4-hydroxycoumarin, dihydrocaffeic acid-3-O-glucuronide, to name some, with less than 5 ppm of mass error.

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Phytochemicals, antioxidant, and antityrosinase activities of Achillea sivasica Çelik and Akpulat

Cited by 19 publications

References 86 publications

UHPLC-QTOF-MS/MS based phytochemical characterization and anti-hyperglycemic prospective of hydro-ethanolic leaf extract of Butea monosperma

UHPLC-QTOF-MS/MS based phytochemical characterization and anti-hyperglycemic prospective of hydro-ethanolic leaf extract of Butea monosperma

Composition and potential of Tanacetum haussknechtii Bornm. Grierson as antioxidant and inhibitor of acetylcholinesterase, tyrosinase, and α-amylase enzymes

Antityrosinase Activity of Combretum micranthum, Euphorbia hirta and Anacardium occidentale Plants: Ultrasound Assisted Extraction Optimization and Profiling of Associated Predominant Metabolites

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