Phytochemicals and their impact on adipose tissue inflammation and diabetes

Leiherer, Andreas; Mündlein, Axel; Drexel, Heinz

doi:10.1016/j.vph.2012.09.002

Cited by 144 publications

(117 citation statements)

References 345 publications

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“…The cells secrete more proinfl ammatory mediators and produce adipose tissue infl ammation ( 1,2 ). AMPK has been considered a central inhibitor of adipose tissue infl ammation ( 28,52 ). Activating AMPK may suppress c-Jun activation ( 52,53 ) and stimulate SIRT1 ( 28,29 ) to inhibit nuclear factor-B (NF-B).…”

Section: Discussionmentioning

confidence: 99%

“…AMPK has been considered a central inhibitor of adipose tissue infl ammation ( 28,52 ). Activating AMPK may suppress c-Jun activation ( 52,53 ) and stimulate SIRT1 ( 28,29 ) to inhibit nuclear factor-B (NF-B). In macrophages, AMPK ␤ activation, which can mainly determine AMPK ␣ 1 activity and expression, attenuates palmitate-or LPS-induced infl ammation through increasing FA oxidation associated with ACC and Cpt1a ( 47 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

Dong¹,

Zhang²,

Zhang

et al. 2014

Journal of Lipid Research

233

167

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

Dong¹,

Zhang²,

Zhang

et al. 2014

Journal of Lipid Research

233

167

View full text Add to dashboard Cite

“…Furthermore, there is increasing evidence of the potential benefits of polyphenols containing catechin in the regulation of cellular processes such as redox control and the inflammatory response based on established animal models and clinical studies (41,42). Recently, our studies have shown that epigallocatechin gallate ameliorates glucose toxicity and renal injury, thereby alleviating renal damage caused by abnormal glucose metabolism-associated oxidative stress in diabetic nephropathy (43).…”

Section: Oligonol Attenuates Diabetes-induced Renal Damage Triggered mentioning

confidence: 98%

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic <i>db/db</i> mice

Park

Noh

Fujii

et al. 2015

DD&T

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“…One of the secondary metabolites of herbal medicine with many advantages are flavonoids [2] . Flavonoids can be found in many vegetables and fruits such as onion, apple, grapes and broccoli [3,4] . Quercetin (QC) is a flavonoid that can be used in disease prevention because it has a high antioxidant activity [5][6][7] .…”

Section: Research Papermentioning

confidence: 99%

In vitro Penetration and Bioavailability of Novel Transdermal Quercetin-loaded Ethosomal Gel

Ramadon¹,

Anwar²,

Harahap³

2017

pharmaceutical-sciences

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Quercetin has been widely used to treat many diseases because of its high antioxidant activity. However, it has low oral bioavailability and penetration through the skin. The aim of this research was to enhance penetration and bioavailability of quercetin using transdermal ethosomal gel. Three ethosomal formulae, E1 (1 %), E2 (1.5 %) and E3 (2 %) with different concentration of quercetin were prepared using thin-film hydration method. Their physical properties were characterized, and then a selected ethosomal formula was incorporated into a gel dosage form. Two gels, one ethosomal and the other non-ethosomal were prepared. In vitro penetration using Franz diffusion cells and bioavailability study in Sprague Dawley male rats were carried out. Results showed that E2 was the chosen formula to be incorporated into the gel dosage form. According to the in vitro penetration study, the diffusion flux of quercetin from the ethosomal and non-ethosomal gels were 343.35±17.69 ng/cm 2 /h and 120.68±11.92 ng/cm 2 /h, respectively (P<0.05). In the bioavailability study, ethosomal gel showed higher maximum concentration (C max ) and area under curve (AUC 0-t ) when compared to non-ethosomal gel and oral suspension. C max from the ethosomal gel, nonethosomal gel, and oral suspension were 413.49±28.64, 189.46±49.68, and 61.92±14.31 ng/ml, respectively (P<0.05). AUC 0-t from the ethosomal gel, non-ethosomal gel, and oral suspension were 4035.15±560.60, 584.87±265.46, and 431.21±239.85, respectively (P<0.05). In conclusion, ethosomal gel could increase penetration and bioavailability of quercetin compared to non-ethosomal gel.

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Phytochemicals and their impact on adipose tissue inflammation and diabetes

Cited by 144 publications

References 345 publications

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic <i>db/db</i> mice

In vitro Penetration and Bioavailability of Novel Transdermal Quercetin-loaded Ethosomal Gel

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