Phytochemical screening, phenolic and flavonoid contents, antioxidant and cytogenotoxicity activities of<i>Combretum leprosum</i>Mart. (Combretaceae)

Sousa, Herbert Gonzaga; Uchôa, Valdiléia Teixeira; Cavalcanti, Suzana Maria Galvão; Almeida, Pedro Marcos de; Chaves, Mariana Helena; Neto, José de Sousa Lima; Nunes, Paulo Humberto Moreira; Júnior, Joaquim Soares da Costa; Rai, Mahendra; Carmo, Iolanda Souza do; Sousa, Elcilene Alves de

doi:10.1080/15287394.2021.1875345

Cited by 31 publications

(9 citation statements)

References 86 publications

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“…They also possess antioxidant and free radical scavenger potential, which can fight against cancer (Lin et al, 2016). Several researchers did the same work, such as Liana and Rungsihirunrat (2021) analyzed the phytoconstituents of 16 indigenous Thai Asteraceae medicinal plants; Sousa et al (2021) carried out the phytochemical screening of Combretum leprosum , and Ibrahim and Ghareeb (2020) analyzed five important medicinal plants for phytochemicals are well in lineage with our findings and described the importance of phytochemical screening of raw drugs, useful for researchers in the fields of pharmacology, phytotherapy, and phytochemistry to conduct advanced research on medicinal plants. The present work on B. asiatica is helpful in exploration of the plant for further advanced research in the above‐mentioned fields.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical and pharmacognostic studies of Buddleja asiatica leaves

Nafees

Barkatullah

Ullah

et al. 2021

Microscopy Res & Technique

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Buddleja asiatica commonly known as "Booi" is a large deciduous shrub belongs to family Scrophulariaceae, traditionally used as antipyretic, analgesic, hypotensive, antimicrobial, anti-inflammatory, and antifungal agent recorded from essential oil obtained from leaves. The literature revealed that the plant has been widely used for many other purposes. The said plant has been analyzed through pharmacognostic techniques such as morphological, microscopic, and physio-chemical evaluations to keep the originality of the plant and to avoid adulteration. Morphologically, the plant is evergreen shrub, while organoleptic studies showed that the leaf has glabrous upper surface and tomentose lower surface, with slightly bitter taste and aromatic odor. Anatomically, the leaf showed typical dicot histological differentiation with hypostomatic nature having highest frequency (90%) of actinocytic stomata. The average stomatal number and stomatal index were 336 ± 39.5 and 30.01 ± 2.34, respectively. The palisade cell ratio, vein termination, and vein islet number were 9.2 ± 0.72, 10.2 ± 3.1, and 10.3 ± 3.3, respectively. Various tissue fragments have been observed during powdered drug analysis of the leaf. Preliminary phytochemical screening confirmed the presence of proteins, phenols, alkaloids, saponins, flavonoids, tannins, and glycosides. Fluorescence analysis in ordinary day light and under UV light along with extractive values was also analyzed. The above-mentioned studies that have been reported, for the first time, for the said plant may be significant to establish the pharmacognostic and phytochemical standards of the said species.

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Section: Resultsmentioning

confidence: 99%

Phytochemical and pharmacognostic studies of Buddleja asiatica leaves

Nafees

Barkatullah

Ullah

et al. 2021

Microscopy Res & Technique

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“…Once achieved, the addition of a solution of 4 mL of 10% Na 2 CO 3 and distilled water until the mark is 10 mL. The solution mixture was homogenized by centrifugation, then allowed to stand for 30 minutes, then the absorbance was measured by UV-Vis spectrometry (Šafranko et al 2021;Sousa et al 2021;Sinaga et al 2022). Total phenolic was determined equivalence with gallic acid as standard.…”

Section: Phenolic Contentmentioning

confidence: 99%

GC-MS analysis of bioactive compounds and antibacterial activity of nangka leaves (Artocarpus heterophyllus Lam)

Tambunan¹,

Siringo-Ringo²,

Butar-Butar³

et al. 2023

PHAR

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Nangka is a plant that has various kinds of potential both because of the nutritional content provided through the fruit and also part of the content of bioactive compounds contained in the leaves. This study aims to identify the content of bioactive compounds and determine their content using GC-MS and determine the potential antibacterial activity against E. coli, S. aureus, S. epidermis, S. typhi, P. acnes from the ethanol extract of nangka leaves (Artocarpus heterophyllus Lam). Screening results showed positive containing phenolic groups, flavonoids, tannins, saponins, and alkaloids. The results of determining the content of bioactive compounds for phenolics, tannins and flavonoids were 27.654±0.054 mg GAE/g d.w ethanolic extract, 0.46±0.017 mg TAE/g d.w ethanolic extract and 2.978±0.192 mg QE/g d.w ethanolic extract. GC-MS analysis showed the content of octadecanoic acid with a retention time of 36.489 minutes with a concentration of 29.91% and the ethanolic extract of nangka leaves had good potential activity as an antibacterial.

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“…Among the studies related to chemical compounds present in C. leprosum, 17 cited the presence of triterpenes, with the molecule 3β-6β-16β-trihydroxylup-20(29)-ene being the most reported in the studies, with 16 records (Table 2 and Figure 4). In addition to these, the presence of flavonoids, steroids, tannins, phenols and saponins was observed (Sousa et al, 2021).…”

Section: Phytochemistrymentioning

confidence: 99%

“…Research, Society and Development, v. 11, n. 11, e190111133446, 2022 (CC BY 4.0) Different parts of the plant were used in the extraction of bioactive compounds, including stem (Sousa et al, 2021), root (Facundo et al, 1993), leaf (Facundo et al, 1993;Evaristo et al, 2014;Nascimento-Neto et al, 2015;Evaristo et al, 2017;Cruz et al, 2019;Silva-Filho et al, 2020;, flor (Pietrovski et al, 2006;Longhi-Balbinot et al, 2012;Viau et al, 2014;Lacouth-Silva et al, 2015;Horinouchi et al, 2017) and fruit (Teles et al, 2011;Teles et al, 2015).…”

Section: Phytochemistrymentioning

confidence: 99%

Combretum leprosum Mart.: Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry and Conservation Needs

Alcântara

Almeida-Bezerra²,

Santos³

et al. 2022

RSD

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Combretum leprosum is a plant species with wide distribution in Brazil known as “mofumbo”, standing out in studies associated with its pharmacological and ethnobotanical activity. The medicinal applications of the species are widely reported in the literature, using the bark, leaves and flowers as healing agents. Given the economic, pharmacological and ecological importance, this work aimed to present a systematic review of production, conservation status and knowledge about the species in different fields of knowledge. The literature review was based on seven categories, characterized according to the study area: biological and/or pharmacological activity (32 articles), importance of conservation status (29), botanical aspects (18), phytochemistry (9), geographic distribution (8), foraging (5) and ethnobotanical uses (2). Most of the works address biological and/or pharmacological activity of the species, and its application is focused on antitumor action, treatment against Chagas disease, antinociceptive behavior, antibacterial, antioxidant, anti-inflammatory and antiproliferative action. Among the compounds isolated from C. leprosum with different applications, 3β-6β-16β-trihydroxylup-20(29)-ene stands out, a lupane triterpene isolated from different parts of the plant, associated with different medicinal and therapeutic applications. The species was highlighted in works associated with environmental regeneration, being resistant to different phytophysiognomies and showing tolerance to environments contaminated by heavy metals, being able to represent an important species in reforestation programs and recovery of degraded environments. However, even with the growing number of studies associated with C. leprosum in recent years, the species does not have an assessment regarding its degree of threat, demonstrating the need for research associated with the species and the possible impacts that its representatives may suffer, helping in sustainable development and conservation programs.

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Phytochemical screening, phenolic and flavonoid contents, antioxidant and cytogenotoxicity activities ofCombretum leprosumMart. (Combretaceae)

Cited by 31 publications

References 86 publications

Phytochemical and pharmacognostic studies of Buddleja asiatica leaves

Phytochemical and pharmacognostic studies of Buddleja asiatica leaves

GC-MS analysis of bioactive compounds and antibacterial activity of nangka leaves (Artocarpus heterophyllus Lam)

Combretum leprosum Mart.: Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry and Conservation Needs

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Phytochemical screening, phenolic and flavonoid contents, antioxidant and cytogenotoxicity activities ofCombretum leprosumMart. (Combretaceae)

Cited by 31 publications

References 86 publications

Phytochemical and pharmacognostic studies of Buddleja asiatica leaves

Phytochemical and pharmacognostic studies of Buddleja asiatica leaves

﻿GC-MS analysis of bioactive compounds and antibacterial activity of nangka leaves (Artocarpus heterophyllus Lam)

Combretum leprosum Mart.: Botany, Ethnomedicinal Uses, Biological Activities, Phytochemistry and Conservation Needs

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GC-MS analysis of bioactive compounds and antibacterial activity of nangka leaves (Artocarpus heterophyllus Lam)