Phytochemical screening of some antidysenteric medicinal plants of Bangladesh

Alamgir, A. N. M.; Fatema, Kaniz

doi:10.3329/jasbs.v39i2.17850

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…However, we noted the strongly presence of phenols in CME , while in an another study [32] reported the low amount of phenolics and flavonoids in aqueous extract of Nigella sativa. Similarly, the presence of flavonoids and phenols in different solvents (ethanol, chloroform, hexane, ethyl acetate and aqueous) was also reported in seed extracts of Cicer arietinum [33,34].…”

Section: Effect Of Cme On Body Weightmentioning

confidence: 80%

Hypoglycemic Potential of Combined Methanolic Extract of Seeds of Nigella sativa (Black Cumin) and Cicer Arietinum (Chickpea)

Akhtar

Malik²,

Siddique

et al. 2021

PJBB

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In spite of the rapid progress in the field of medicine, humanity still striving for cure of diabetes, a disorder of metabolism. From literature study it is inferred that no one therapeutic agent is isolated and/ or synthesized to treat diabetes, but to manage the disease. Therefore, it is of much importance to address this medical issue with phytochemical synergism for boosting immunity and limiting the severe side effects of synthetic hypoglycemic agents. The antioxidant and hypoglycemic effects of black seeds and chickpea have been determined previously, however the combined hypoglycemic effect of these seeds has not been studied until now. In present study the combined methanolic extract (CME) of Nigella sativa (black cumen) and Cicer arietinum (chickpea) seeds has shown the significant antioxidant potential as revealed by its significantly reduced IC50 value for radical scavenging activity in DPPH assay (-36.39%, p<0.001) compared to the standard compound butylated hydroxyanisole (BHA), and also due to the presence of significant (p<0.001) amount of total phenolic contents (TPC) in the mixture (254.2+2.75 mg GAE/g of dry weight). The CME was also fractionated through column chromatography and based on the phytochemical analysis, the fractions enriched with phenolic compounds were isolated and characterized by FT-IR spectroscopy. The IR-spectra have shown the presence of respective functional groups, indicating the isolation of specific phenol enriched compounds from CME which may be further used for drug development. During the evaluation of antidiabetic potential of CME in alloxan induced diabetic rats, the animals showed non-significant (p>0.05) increase (2.12%) in observed body weights, however, showed the significant decrease in blood glucose levels (-42.24%, p<0.001) compared to the diabetic control rats. Our findings suggest that CME may be used as a potential hypoglycemic herbal medication or might be used in conjunction with the usual synthetic drugs to boost activity and limit the side effects.

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Section: Effect Of Cme On Body Weightmentioning

confidence: 80%

Hypoglycemic Potential of Combined Methanolic Extract of Seeds of Nigella sativa (Black Cumin) and Cicer Arietinum (Chickpea)

Akhtar

Malik²,

Siddique

et al. 2021

PJBB

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“…90 A wide range of secondary metabolites were accounted for to be available in various antidysenteric, antidiarrheal and other medicinal plants. [91][92][93][94][95] On the other hand, significant antimicrobial activity especially against E. Coli, Shigella, V. cholerae and Salmonella were reported by different antidysenteric medicinal plants. [96][97][98][99][100][101][102][103][104] Earlier studies have shown that the antidysenteric and antidiarrheal activities of different medicinal plants were because of tannins, alkaloids, saponins, flavonoids, steroids, terpenes and glycosides contained in them.…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacological Survey of Medicinal Plants Used by Traditional Health Practitioners and Indigenous People in Chittagong Hill Tracts, Bangladesh for the Treatment of Dysentery

Das

Bhadra

Khan

et al. 2022

Dhaka Univ. J. Pharm. Sci

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Dysentery is frequently associated with high morbidity and mortality and is found in young children and mainly affects those in developing nations. Rural people across the world trust on herbal remedies and homeopathic medicines for their primary health care on account of their easy accessibility, efficacy and exceptionally cost ampleness in relation to modern drugs. The purpose of the present study was to compile knowledge of traditional healers and indigenous people in Chittagong hill tracts, Bangladesh, including Rangamati, Bandarban and Khagrachari for the treatment of dysentery. The ethnomedicinal data was gathered from January 2019 to January 2020 through open and focused group discussions and individual meetings utilizing semi-structured questionnaire. An aggregate of 75 people were interviewed, including traditional health practitioners. Frequency and percentage were utilized to sum up the data. Relative frequency of citation (RFC) was determined and inclination positioning activities were led to appraise the significance of the revealed medicinal plants. An aggregate of 90 medicinal plants from 52 families and 79 genera were recorded during the survey. Leaves were discovered to be the most largely used plant part (35%) followed by root (19%) and herbs (40%) were the essential wellspring of medicinal plants, followed by trees (20%). The major mode of preparation is juice (68%) followed by paste (11%) and cooked form (7%). Centella asiatica scored the highest RFC value (0.773). The survey addresses the preliminary information of certain medicinal plants having anti-dysenteric property. However, further phytochemical investigation, validation and clinical trial sought to be conducted, with need given to those that scored the most elevated RFC values prior to utilizing these plants as an option in contrast to modern medicine. Dhaka Univ. J. Pharm. Sci. 21(2): 127-146, 2022 (December)

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Phytochemical screening of some antidysenteric medicinal plants of Bangladesh

Cited by 2 publications

References 15 publications

Hypoglycemic Potential of Combined Methanolic Extract of Seeds of Nigella sativa (Black Cumin) and Cicer Arietinum (Chickpea)

Hypoglycemic Potential of Combined Methanolic Extract of Seeds of Nigella sativa (Black Cumin) and Cicer Arietinum (Chickpea)

Ethnopharmacological Survey of Medicinal Plants Used by Traditional Health Practitioners and Indigenous People in Chittagong Hill Tracts, Bangladesh for the Treatment of Dysentery

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