Phytochemical Screening of Methanolic Extract of Urtica dioica L.: Antioxidant and Antimicrobial Power for Food Safety

Belmamoun, Ahmed Reda; Chafik, Mhamdia; Abdelkader, Ammam; Afaf, Baki; Chadli, Redouane; Benmaissa, Houria

doi:10.21608/eajbsc.2023.280924

Cited by 1 publication

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“…The DPPH scavenging activity of UPL in this study was 78%, and its IC 50 was 5.89 ± 0.45 mg/mL. These results were in accordance with a previous study that screened the antioxidant activity of Urtica and reported a DPPH scavenging activity of 77.85% with an IC 50 of 4.69 mg/mL (Belmamoun et al, 2023). Moreover, the chelating activity of hydroalcoholic extracts of UPL in the present study showed a percentage chelation of 84%, and Frontiers in Molecular Biosciences frontiersin.org the EC 50 value was 375.72 μg/mL.…”

Section: Discussionsupporting

confidence: 92%

Urtica pilulifera leaves extract mitigates cadmium induced hepatotoxicity via modulation of antioxidants, inflammatory markers and Nrf-2 signaling in mice

Hussein,

Ben Bacha,

Alonazi

et al. 2024

Front. Mol. Biosci.

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Introduction: Cadmium (Cd) is a harmful heavy metal that results in many toxic issues. Urtica pilulifera showed potential pharmaceutical applications. This study investigated the possible ameliorative mechanism of Urtica pilulifera leaves extract (UPLE) against hepatotoxicity induced by cadmium chloride (CdCl2) in mice.Methods:In vitro phytochemical screening and the metal-chelating activity of UPLE were ascertained. Four groups of forty male mice were used (n = 10) as follows; Group 1 (G1) was a negative control. G2 was injected i.p., with UPLE (100 mg/kg b. wt) daily. G3 was injected i.p., with Cd (5 mg/kg b. wt) daily. G4 was injected with Cd as in G3 and with UPLE as in G2. On day 11, the body weight changes were evaluated, blood, and serum samples were collected for hematological and biochemical assessments. Liver tissues were used for biochemical, molecular, and histopathological investigations.Results: The results showed that UPLE contains promising secondary metabolites that considerably lessen the negative effects of Cd on liver. Furthermore, UPLE inhibited oxidative stress and inflammation; restored antioxidant molecules; and promoted nuclear-related factor-2 (Nrf-2) expression. Also, UPLE improved the histopathological alterations induced by Cd.Discussion: This study explored the beneficial role of UPLE treatment in Cd-induced liver injury through enhancing Nrf-2 signaling and antioxidant enzyme gene expression in the liver of mice. Therefore, UPLE could have valuable implications against hepatotoxicity induced by environmental cadmium exposure. Which can be used as a chelating agent against Cd.

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Section: Discussionsupporting

confidence: 92%