Phytochemical screening of aqueous leaf extract of Blighia sapida K.D. Koenig (Sapindaceae) and its analgesic property in mice

Olayinka, Juliet Nnenda; Ozolua, Raymond I.; Akhigbemen, Abigail M.

doi:10.1016/j.jep.2021.113977

Cited by 10 publications

(9 citation statements)

References 35 publications

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“…Blighia sapida is a member of the Sapindaceae family and Sapindales order, commonly known as ackee or breadfruit (Olayinka et al, 2021). It is distributed across nations around the world, including Spain, Guatemala, Panama, Mexico, Venezuela, Colombia, Costa Rica, Portugal, France, Portugal, and Surinam (Olayinka et al, 2021;Aloko et al, 2019). Traditional medicine claims that the ackee fruit has medicinal characteristics that can be used to treat or relieve symptoms such as fever, constipation, skin infections, and diarrhea.…”

Section: Receptor Grid Generationmentioning

confidence: 99%

Section: Receptor Grid Generationmentioning

confidence: 99%

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Protein-Ligand Based Pharmacophore Approach against ERK5 Involved in Breast Cancer; In-Silico Study of Flavonoids from Blighia sapida

Bodun

Omoboyowa

Adedara

et al. 2022

Preprint

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Conclusions: Flavonoids from B. sapida may serve as promising inhibitors of ERK5 for breast cancer management. Background: Breast cancer is a global public health issue that can be caused by environmental or hereditary factors. There are still a shortage of effective treatments with enhanced efficacy and acceptability against the disease, as many breast cancer drugs have serious side effects. Hence, the inhibitory potential of flavonoids from Blighia sapida against breast cancer target (ERK5) was investigated. The interactions of the target protein and its co-crystallized ligand were used to develop a protein-ligand based pharmacophore hypothesis. The idea was applied to the screening of phytochemicals obtained from an online database. Following that, we used structural bioinformatics and theoretical chemistry tools to find new ERK5 inhibitors using molecular docking, molecular mechanics generalized Born surface area (MM-GBSA) and pharmacokinetics model in Schrödinger suite, density functional theory analysis (DFT) was also performed using Spartan 10. Results: The technique discovered new lead molecules as inhibitors of ERK5 as breast cancer therapy through molecular docking and MM/GBSA calculation with Quercetin, Kaempferol and (+)-Catechin showing higher docking score than the co-cystalized ligand and the standard drug. In the phase-generated E-pharmacophore theory, the postulated pharmacophore hypothesis has a hydrogen bond acceptor, hydrogen bond donor, and aromatic ring. Interestingly, all the hits obeyed Lipinski rule of five. The results of the frontier molecular orbitals revealed that the EHOMO values of the hit compounds range from -6.02 to -5.48 eV indicating that all the hit compounds will readily donate electron. Conclusions: Flavonoids from B. sapida may serve as promising inhibitors of ERK5 for breast cancer management.

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Section: Receptor Grid Generationmentioning

confidence: 99%

Section: Receptor Grid Generationmentioning

confidence: 99%

Protein-Ligand Based Pharmacophore Approach against ERK5 Involved in Breast Cancer; In-Silico Study of Flavonoids from Blighia sapida

Bodun

Omoboyowa

Adedara

et al. 2022

Preprint

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“…The hot plate induced pain in mice was examined using a method described by Olayinka et al (2021). Mice (25) of either sex were randomly allocated to five groups (n=5).…”

Section: Hot Plate Induced Pain In Micementioning

confidence: 99%

“…Acetic acid induced writhing in mice was examined using the method described by Koster et al (1959) and modified by Olayinka et al (2021). Mice (25) of either sex were randomly allocated to five groups (n=5): Group 1 was given 2 mL/kg of distilled water as a control; Group 2 was given 100 mg/kg of the extract; Group 3 was given 200 mg/kg of the extract; Group 4 was given 400 mg/kg of the extract; and Group 5 was given acetylsalicylic acid (100 mg/kg).…”

Section: Acetic Acid Induced Writhing In Micementioning

confidence: 99%

Evaluation of the Antitussive and Analgesic Activities of Peperomia pellucida Whole Plant Methanol Extract in Rodents

Uwaya

Ikuoyemwen

Aghedo

2022

Pharmacol Toxicol Nat Med

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Background and Purpose: Peperomia pellucida (Piperaceae) is a plant used in ethnomedicine to treat asthma, colds, coughs, and other illnesses. This study aimed to evaluate the antitussive, expectorant, and analgesic activities of a 70% methanol extract of the plant. Methods: Citric acid and ammonia-induced rodent cough models; and phenol red dye expectorant models in mice were used to evaluate the antitussive and expectorant properties of the orally administered extract. The hot plate and acetic acid-induced mouse writhing models were used to evaluate analgesia. Results: Dihydrocodeine (25 mg/kg); and 100, 200, and 400 mg/kg of the extract significantly reduced the frequency of cough bouts and increased the percentage suppression of cough-in citric acid and ammonium hydroxide-induced cough models compared with control (P<0.05, P<0.01, P<0.001). Bromhexine (15 mg/kg); 100 and 400 mg/kg of the extract increased the secretion of phenol red dye in mice when compared with the control (P<0.05, P<0.01). Doses of the extract (100, 200 mg/kg) and pentazocine (3 mg/kg) increased (P<0.05) the latency to response time in hot plate-induced pain. At 400 mg/kg, the extract; and acetylsalicylic acid (100 mg/kg) reduced the number of writhing and increased the percentage inhibition of pain in the acetic acid-induced model when compared to the control (P<0.05, P<0.001). Conclusion: The 70% methanol extract of P. pellucida possesses antitussive, expectorant, and analgesic activities in rodents.

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“…Medicinal plants and their bioactive compounds, especially phenolic acids and flavonoids, are widely reported to cure wounds and ameliorate the healing process by interfering with cyclooxygenase and prostaglandin biosynthesis [ 17 , 18 , 19 , 20 ]. Many studies have proved the analgesic and the anti-inflammatory potential of several medicinal plants [ 21 , 22 , 23 , 24 ]. Among these plants, Dittrichia viscosa L., a perennial plant (Asteraceae), is characterized by the production of numerous bioactive compounds such as flavonoids, phenolic acids, sesquiterpene lactones, monoterpenes, and triterpenoids [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Ointment-Based Combination of Dittrichia viscosa L. and Marrubium vulgare L. Accelerate Burn Wound Healing

et al. 2022

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Burns constitute a major challenge in medical science, and plants can be part of the solution. Dittrichia viscosa L. (Asteraceae) and Marrubium vulgare L. (Lamiaceae) are widely used in Moroccan traditional medicine to treat several diseases and possess high potency to cure wounds. This study aimed to investigate in vivo the analgesic, anti-inflammatory, and burn-healing effects of both plants and their mixture. The hydro-ethanolic extract of both plants was analyzed using high-performance liquid chromatography with diode-array detection (HPLC-DAD). Burns were conducted on dorsal part of rats, and the wound healing process was evaluated during 21 days. Gallic acid, caffeic acid, ferulic acid, and quercetin were identified in M. vulgare extract. The analysis recorded the presence of caffeic acid, rosmarinic acid, rutin, and quercetin in D. viscosa. The group treated with the mixture showed the lowest abdominal contractions (30.4 ± 7.52) with the highest percentage of inhibition (69.12 ± 7.04%). The inhibition of paw inflammation for M. vulgare was 47.65%, followed by D. viscosa (33.86%) and the mixture (30.41%). The mixture showed the highest wound contraction at day 7 (33.16 ± 14.33%) and day 14 (87.54 ± 3.98%). D. viscosa showed the highest wound contraction on the 21st day (99.28 ± 0.44%). In conclusion, both plants and their combination showed promising results for burn healing.

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Phytochemical screening of aqueous leaf extract of Blighia sapida K.D. Koenig (Sapindaceae) and its analgesic property in mice

Cited by 10 publications

References 35 publications

Protein-Ligand Based Pharmacophore Approach against ERK5 Involved in Breast Cancer; In-Silico Study of Flavonoids from Blighia sapida

Protein-Ligand Based Pharmacophore Approach against ERK5 Involved in Breast Cancer; In-Silico Study of Flavonoids from Blighia sapida

Evaluation of the Antitussive and Analgesic Activities of Peperomia pellucida Whole Plant Methanol Extract in Rodents

Ointment-Based Combination of Dittrichia viscosa L. and Marrubium vulgare L. Accelerate Burn Wound Healing

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