Phytochemical Screening by High-Performance Thin-Layer Chromatography, Antioxidant Activities and Acute Toxicity of Trunk Barks Extracts of &amp;lt;i&amp;gt;Lannea velutina&amp;lt;/i&amp;gt; A. Rich

Kabore, Boukaré; Koala, Moumouni; Nitiéma, Mathieu; OUEDRAOGO, Windingoudi Rimwagna Christian; Compaoré, Souleymane; Belemnaba, Lazare; Ouedraogo, Salfo; Ilboudo, Sylvain; Ouédraogo, Noufou; Dabiré, Constantin M.; Kini, Félix B.; Ouédraogo, Sylvin; Palé, Éloi

doi:10.4236/ajac.2022.1310025

Cited by 5 publications

(4 citation statements)

References 26 publications

(43 reference statements)

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“…L. velutina bark and leaf ethanolic extracts showed antioxidant and antimicrobial in vitro activities. Anacardic acid has previously been identified as one of the major compounds present in this medicinal plant [ 57 , 58 , 62 , 74 , 79 , 80 ].…”

Section: Resultsmentioning

confidence: 99%

Ethnomedicinal, Chemical, and Biological Aspects of Lannea Species—A Review

Malú,

Caldeira,

Catarino

et al. 2024

Plants

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Lannea L. genus belongs to the Anacardiaceae botanical family and has long been used in traditional medicinal systems of many countries to manage several health conditions, but no studies have been conducted regarding its usefulness as a source of herbal medicine for human use. A literature review was conducted on scientific papers indexed on B-On, Pubmed, and Web of Science databases. Our results showed that medicinal plants from this botanical genus, mostly constituted by bark and leaf, are often used to approach a wide variety of disease symptoms, like fever, inflammatory states, pain, and gastrointestinal disorders. Phytochemical profiles of Lannea species revealed that phenolic acid derivatives including hydroquinones, phenolic acids, flavonoids, condensed tannins, and triterpenoids are the main classes of secondary metabolites present. Among the total of 165 identified compounds, 57 (34.5%) are flavonoids, mostly quercetin- and myricetin-derived flavonols and catechin and epicatechin flavan-3-ol derivatives also containing a galloyl group. In vitro and in vivo studies allowed the identification of 12 different biological activities, amongst which antimicrobial, antioxidant, anti-inflammatory, and cytotoxic activities were the most frequently cited and observed in in vitro essays. Our review contributes useful information for the scientifical validation of the use of Lannea species in traditional medicinal systems and shows that more research needs to be conducted to better understand the concrete utility of these as herbal medicines.

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Section: Resultsmentioning

confidence: 99%

Ethnomedicinal, Chemical, and Biological Aspects of Lannea Species—A Review

Malú,

Caldeira,

Catarino

et al. 2024

Plants

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“…Rich (Anacardiaceae) [23]. According to the literature, saponosides [24], tannins [6] [8], sterols and triterpenes [8] [25] [26] have diuretic, vasodilatory and antihypertensive properties, both on the conductance arteries of normotensive and spontaneously hypertensive rats (SHR).…”

Section: Discussionmentioning

confidence: 99%

Acute Oral Toxicity and Vasorelaxant Effects of Hydroethanolic Extract from <i>Lannea microcarpa</i> Engl. & K. Krause (Anacardiaceae) Trunk Barks in Mice Aortas: Possible Involvement of Intracellular Ca<sup> 2+</sup> Mobilization

Nitiéma,

Kafando,

Ouédraogo

et al. 2023

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Lannea microcrapa Engl. & K. Krause (Anacardiaceae) is a fruit and medicinal plant widely used in Burkina Faso. This plant is traditionally used in the treatment of hypertension. The aim of the present study was to evaluate the vasorelaxant effects of the hydroethanolic extract from Lannea microcarpa trunk barks (HE_ELM) on the aorta isolated from NMRI mice. Phytochemical screening by HPTLC, assay of phenolic and flavonoid compounds, assessment of antioxidant activity (DPPH, ABTS, FRAP, and LPO), and myography of HE_ELM (1 -2000 µg/mL) on mice thoracic aortas in the presence and absence of endothelium were carried out. Endothelium-dependent and endothelium-independant vasodilation were assessed by cumulative addition of Ach (1 nM -10 μM) on aortic rings precontracted with the thromboxane analogue A2 agonist, 9,11-dideoxy9α,11α-methanoepoxy PGF2α (U46619). L-NAME was used to verify the involvement of NO production in the relaxation mechanism of the extract. Acute oral toxicity of HE_ELM was also evaluated. A phytochemical study revealed the presence of tannins, flavonoids, sterols and triterpenes, saponosides, and high levels of total phenolics and flavonoids. These compounds are thought to be responsible for the extract's antioxidant and vasorelaxant properties. HE_ELM demonstrated significant

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“…Determination of the 2,2-DPPH Radical Scavenging Activity. The 2,2-DPPH • radical scavenging activity was assessed using a Shimadzu UV-Vis Spectrophotometer [22]. Trolox and plant extracts were dissolved in methanol to yield a final 1 mg/mL concentration, from which diluted solutions were prepared.…”

Section: Lipoxygenase (Lox) Inhibitionmentioning

confidence: 99%

Phytochemical Study and In Vitro Biological Activities of Hibiscus panduriformis Burm. f. (Malvaceae), Alternanthera pungens Kunth (Amaranthaceae), and Wissadula rostrata (Schumach.) Hook. f. (Malvaceae)

Rainatou,

Esther,

Boukaré

et al. 2023

BioMed Research International

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The present study investigated the phytochemical content of Hibiscus panduriformis, Alternanthera pungens, and Wissadula rostrata and assessed their radical scavenging and anti-inflammatory properties. n-Hexane, dichloromethane (DCM), ethyl acetate, and methanol extracts were prepared from the powdered plant parts. The phytochemical analysis was performed using qualitative high-performance thin-layer chromatography, and polyphenols were quantified using well-established methods. The anti-inflammatory effect was by lipoxygenase inhibition, while the antiradical impact was evaluated through DPPH and ABTS radicals. Steroids, triterpenoids, flavonoids, and tannins were identified in the three plants. The highest phenolic content (95.67±2.19 mg gallic acid equivalent/g) was obtained in the methanolic extract of W. rostrata, while the lowest was measured in H. panduriformis. H. panduriformis was found to be highly rich in flavonoids (61.22±0.09 mg rutin equivalent/g), condensed tannins (62.53±0.03 mg catechin equivalent/g), and hydrolyzable tannins (125.1±1.02 mg tannic acid equivalent/g). The methanolic extract of H. panduriformis displayed the greatest antilipoxygenase activity with an IC50 value of 8.78±1.05 μg/mL. It should be noted that although a moderate to low effect was observed, the extracts were more likely to scavenge DPPH (IC50 values ranged from 0.106±0.010 to 1 mg/mL) than ABTS radicals. There was a strong to moderate correlation between the antilipoxygenase and DPPH radical scavenging effects of the methanolic extracts and total phenolic content (antilipoxygenase, r=0.7175; DPPH, r=0.9376). Furthermore, it is worth noting that this is the first report investigating the phytochemical analysis and in vitro biological properties of Hibiscus panduriformis. The results highlighted the richness of this plant in polyphenols and demonstrated its high and moderate effects on lipoxygenase and DPPH radicals, respectively. To this intent, further in vivo and in vitro studies on this plant, along with exhaustive phytochemical analysis, are needed.

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Phytochemical Screening by High-Performance Thin-Layer Chromatography, Antioxidant Activities and Acute Toxicity of Trunk Barks Extracts of <i>Lannea velutina</i> A. Rich

Cited by 5 publications

References 26 publications

Ethnomedicinal, Chemical, and Biological Aspects of Lannea Species—A Review

Ethnomedicinal, Chemical, and Biological Aspects of Lannea Species—A Review

Acute Oral Toxicity and Vasorelaxant Effects of Hydroethanolic Extract from <i>Lannea microcarpa</i> Engl. & K. Krause (Anacardiaceae) Trunk Barks in Mice Aortas: Possible Involvement of Intracellular Ca<sup> 2+</sup> Mobilization

Phytochemical Study and In Vitro Biological Activities of Hibiscus panduriformis Burm. f. (Malvaceae), Alternanthera pungens Kunth (Amaranthaceae), and Wissadula rostrata (Schumach.) Hook. f. (Malvaceae)

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Phytochemical Screening by High-Performance Thin-Layer Chromatography, Antioxidant Activities and Acute Toxicity of Trunk Barks Extracts of &lt;i&gt;Lannea velutina&lt;/i&gt; A. Rich

Cited by 5 publications

References 26 publications

Ethnomedicinal, Chemical, and Biological Aspects of Lannea Species—A Review

Ethnomedicinal, Chemical, and Biological Aspects of Lannea Species—A Review

Acute Oral Toxicity and Vasorelaxant Effects of Hydroethanolic Extract from &lt;i&gt;Lannea microcarpa&lt;/i&gt; Engl. &amp; K. Krause (Anacardiaceae) Trunk Barks in Mice Aortas: Possible Involvement of Intracellular Ca&lt;sup&gt; 2+&lt;/sup&gt; Mobilization

Phytochemical Study and In Vitro Biological Activities of Hibiscus panduriformis Burm. f. (Malvaceae), Alternanthera pungens Kunth (Amaranthaceae), and Wissadula rostrata (Schumach.) Hook. f. (Malvaceae)

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Phytochemical Screening by High-Performance Thin-Layer Chromatography, Antioxidant Activities and Acute Toxicity of Trunk Barks Extracts of <i>Lannea velutina</i> A. Rich

Acute Oral Toxicity and Vasorelaxant Effects of Hydroethanolic Extract from <i>Lannea microcarpa</i> Engl. & K. Krause (Anacardiaceae) Trunk Barks in Mice Aortas: Possible Involvement of Intracellular Ca<sup> 2+</sup> Mobilization