A b s t r a c tSickle cell disease is a major public health problem. It is the first genetic disease in the world. FACA syrup offers an alternative treatment. It is a dry powder preparation of two components, the roots barks of Zanthoxylum zanthoxyloides Lam. (Rutaceae) Zepernick, Timler and Calotropis procera.Ait. R.B.r. (Asclepiadaceae). The product was developed at Institute for Research in Health Sciences (IRSS) from a traditional recipe used in Burkina Faso for treatment of sickle cell crises. This study aimed to establish physical-chemical, pharmaco technical and microbiological control parameters essential for the standardization of the phytomedicine. This valuation concerned specifications of moisture content, pH, the fingerprint by thin layer chromatography, pesticide residues, heavy metal content, microbial quality, and total ash. These charcteristics were determined by the methods prescribed by the World Health Organization (1998) and the European Pharmacopoeia 6th edition. The results have shown that dry syrups and reconstituted syrups were sweet, slightly spicy with a bitter after taste, a white room color and a faint odor. The density at the preparation was 0.985 and the pH was 5.93. After 2 months of storage in the laboratory, the organoleptic parameters of the reconstituted syrups have not changed. They were mold free, the density remained around 1 and the pH between 5 and 4. These parameters have shown that the quality of plants powders and this medicine comply with the recommendations of the European pharmacopoeia. Faca syrup may contribute to the better management of sickle cell disease in children.

Diabetes mellitus is a socially significant disease characterized by chronic hyperglycemia and metabolic disorders of proteins, carbohydrates, and lipids due to reduced function of insulin. Medicinal plants, rich in bioactive components that promote prevention and treatment, are inexpensive and no side effects. Apium graveolens, Cleome gynandra, and Hibiscus sabdariffa from Burkina Faso were investigated for their phytochemical profile and antioxidant activities. The high-performance thin-layer chromatography profile revealed flavonoids, tannins, and sterols in these herbaceous. The Hibiscus sabdariffa methanolic extract exhibited the highest total phenolic (138.4 ± 0.5 mg GAE/g DW) and flavonoid (52.8 ± 0.6 mg RuE/g DW) contents comparatively to Cleome gynandra and Apium graveolens. Hibiscus sabdariffa methanolic extract also presented the highest antioxidant activity (IC 50 = 0.31 ± 0.002 mg/mL) using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity assay. A high correlation between flavonoid contents and hydrophilic antioxidant activities (r = 0.99) was observed, indicating that flavonoids contribute significatively to these herbaceous antioxidant properties.Apium graveolens, Cleome gynandra, and Hibiscus sabdariffa constitute a natural source of phenolic compounds that could be exploited in diabetes mellitus management.

The availability of secondary metabolites in various plant parts can be influenced qualitatively and quantitatively by managing ecological factors or farming practices. Purpose of this study was to determine the impact of organic and mineral fertilization on the content of phenolic compounds and antioxidant activity in fruit of the tomato Mongal F1 variety. Experimentation was carried out in a randomized block factorial design. Results of study revealed that plant treated by organic fertilizers have 16.36± 0.07mg Trolox Equivalent (TE)/100g fresh tomato (ft) antioxidant activity and 6.96± 0.63mg Gallic Acid Equivalent (GAE)/100g ft total phenols content while the plant treated by mineral fertilizer have 15.57± 0.05 mg TE/100g ft for antioxidant activity and 6.09± 0.13mg GAE/100g ft for total phenols content. Furthermore, it was reported that, as compared to mineral fertilization, organic fertilization significantly increases the antioxidant activity and phenolic compounds production in Mongal F1 tomato variety. This increase is probably due to the availability of various major and minor elements in organic fertilizer contrary to mineral fertilizer which has only three major elements, nitrogen, phosphorus, and potassium. 79 days after transplanting, fruit ripping has no obvious effect on the accumulation of these compounds.

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Aims: Hydroethanolic extracts of Balanites aegyptiaca, Securidaca longepedunculata and Acacia gourmaensis from Burkina Faso were investigated for their phytochemical composition and their antioxidant activities. Methods: Highperformance thinlayer chromatography (HPTLC) method was used for phytochemical screening. The total phenolic, total flavonoid and anthocyanin contents of extracts CJAST, 39(1): 79-87, 2020; Article no.CJAST.54710 80 were assessed. The antioxidant potentials of the extracts were also evaluated using 2,2diphenyl lpicrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP). Results: Phenolic compounds, flavonoids and anthocyanins were present in all these plant extracts. Tannins were only found in Acacia gourmaensis extract. Acacia gourmaensis extract exhibited the highest total phenolics (807.58 ± 28.63 mg GAE/g), total flavonoids (271.39 ± 58.46 mg QE/100 g), total anthocyanins (83.16 ± 0.14 µg/g) contents and had the highest antioxidant activity by DPPH ( 330.84 ± 16.23 µg AAE/g) and FRAP methods (3211.11 ± 52.24 µg AAE/g ). Balanites aegyptiaca and Securidaca longepedunculata showed the lowest phenolic compounds (80.72 ± 2.11 mg GAE/g and 76.69±1.84 mg GAE/g respectively); total flavonoids (88.7 ± 1.65 mg QE/100 g and 104.54 ± 9.65 mg QE/100 g respectively), anthocyanins (24.49±1.43 µg/g and 24.57±0.52 µg/g respectively) contents and had the lowest antioxidant activity for DPPH method ( 46.83 ± 3.01 and 56.20 ± 3.79 µg AAE/g respectively) and FRAP method ( 102.06 ± 5.09 and 57.78 ± 0.99 µg AAE/g respectively). Conclusion: Balanites aegyptiaca, Securidaca longepedunculata and Acacia gourmaensis represent natural sources of phenolic antioxidant compounds that can be used as a biofungicide. Original Research Article