Phytochemical Screening, Antioxidant Activity, and Anti- Inflammatory Potential of Rhinachantus nasutus (L.) Kurz Flower Ethanol Extract

Irawan, Candra; Elya, Berna; Hanafi, Muhammad; Saputri, Fadlina Chany

doi:10.5530/pj.2022.14.129

Cited by 4 publications

(6 citation statements)

References 17 publications

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“…18 There was a correlation found between the high antioxidant activity and the results of the phytochemical screening. Alkaloids, phenolic chemicals, tannins, and flavonoids were found in the ethanol extract of RnLK flower, as well as flavonoids, according to a prior 3 . Polyphenols include both flavonoids and tannins as constituents.…”

Section: Antioxidant Capacity With Frap Methodsmentioning

confidence: 94%

“…26 It has been stated in the past that RnLK flower extract possesses phenolic chemicals. 3 Due to the fact that xanthine oxidase prefers to oxidize poly phenolic compounds rather than xanthine, the presence of this substance can cause a reduction in the generation of uric acid. 27,28…”

Section: Antigout Activitymentioning

confidence: 99%

“…1,2 It was discovered that flowers extracted in ethanol contain steroid glycosides, alkaloids, flavonoids, phenolics, and tannins, as well as significant DPPH radical scavenging properties and the potential to be employed as anti-inflammatory medications. 3 There is evidence that certain compounds, such as steroid glycosides, alkaloids, flavonoids, phenolics, and tannins, possess antibacterial characteristics. 4,5 Natural substances that inhibit the growth of bacteria are increasingly being utilized in place of synthetic antibiotics in the treatment of diseases.…”

Section: Introductionmentioning

confidence: 99%

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The Ethanolic Extract of Rhinachantus nasutus (L.) Kurz Flower has Antioxidant, Anti-Gout, and Antibacterial Potential

Irawan¹,

Elya²,

Hanafi³

et al. 2023

Pharmacogn J.

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The goal of this research was to explore the potential of Rhinachantus nasutus (L.) Kurz (RnLK) flower extract as an antioxidant utilizing the ferric reducing antioxidant power (FRAP) method; the possibility that it might be used as a treatment for gout by employing the 2,4,6-tribromo-3-hydroxybenzoic acid (TBHBA) technique, as well as the possibility that it could be used as an antibacterial agent against E. coli and B. subtilis. Results: The IC 50 value for the extract's ability to serve as an antioxidant is 8.62±0.006 mg/L, indicating that it is quite effective. In addition, the extract of ethanol possesses highly potent anti-gout properties, being capable of bringing about a 81.95±0.1% reduction in uric acid levels. In spite of this, the antibacterial properties of E. coli as well as B. subtilis bacteria were not particularly robust. Conclusion:The RnLK flower has the potential to produce alternative chemicals with the ability to reduce blood uric acid levels, but according to the results of the test, the antibacterial activity has little impact on E. coli and B. subtilis.

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Section: Antioxidant Capacity With Frap Methodsmentioning

confidence: 94%

Section: Antigout Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Ethanolic Extract of Rhinachantus nasutus (L.) Kurz Flower has Antioxidant, Anti-Gout, and Antibacterial Potential

Irawan¹,

Elya²,

Hanafi³

et al. 2023

Pharmacogn J.

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“…There was a relationship between the inhibitory action against α-glucosidase, TPC, TFC, phytochemical content, and antioxidant activity test results. According to [25], the existence of phenolic groups, which can donate hydrogen atoms to free radicals to reduce their responsiveness, is linked to the antioxidant and anti-diabetic properties of the plant extract. Furthermore, [25,26] stated that by employing hydrophobic connections, phenolic compounds can also operate as α-glucosidase selective competitors, an enzyme that breaks down carbs.…”

Section: α-Glucosidase Enzyme Activity Inhibition Testmentioning

confidence: 99%

“…According to [25], the existence of phenolic groups, which can donate hydrogen atoms to free radicals to reduce their responsiveness, is linked to the antioxidant and anti-diabetic properties of the plant extract. Furthermore, [25,26] stated that by employing hydrophobic connections, phenolic compounds can also operate as α-glucosidase selective competitors, an enzyme that breaks down carbs. These carbohydrates are not hydrolyzed directly into glucose molecules.…”

Section: α-Glucosidase Enzyme Activity Inhibition Testmentioning

confidence: 99%

Chisocheton pentandrus (Blanco) Merr. leaf as a potential antioxidant and α-glucosidase inhibitory agent

Wibawa,

Hanafi,

Minarti

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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Indonesia is one of the countries with the highest diversity of plants worldwide, including the Chisocheton genus. The Chisocheton genus has been widely used in traditional medicine due to a variety of compounds with different activities, such as antiplasmodial, antiviral, and anti-inflammatory. The focus of this research is to determine the antioxidant, anti-diabetic, and anti-bacterial activity of Chisocheton pentandrus leaf extract from the Bali Botanic Garden plant collection, as well as the chemical compounds contained in the extract. The antioxidant activity test was carried out by capturing DPPH-free radicals, the antidiabetic test was carried out by assaying its inhibitory activity toward α-glucosidase enzyme, the antibacterial test was carried out using the agar diffusion method, while LC-MS/MS was used to determine the compounds contained in the extract. The results showed that the C. pentandrus leaf methanol extract showed the highest inhibitory activity as an antioxidant and inhibitor of the α-glucosidase enzyme in the very strong category; however, the extract is not effective in inhibiting bacterial growth.

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Antinociceptive and anti-inflammatory effect of Passiflora edulis leaves extract in acetic acid-induced pain and carrageenan-induced paw oedema in vivo

Sandhiutami,

Desmiaty,

Fahleni

et al. 2024

Pharm Educ

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Background: In Indonesia, people commonly treat pain and inflammation with herbs. Passiflora edulis leaves extract (PLE) is known to contain many chemical compounds that are useful as analgesic and anti-inflammatory treatments. However, there is very limited scientific literature that reports the results of P. edulis in reducing pain and inflammation. Objective: This research aims to evaluate the antinociceptive and anti-inflammatory effects of PLE. Method: PLE was extracted by Ultrasonic-Assisted Extraction (UAE). The PLE at doses of 20, 40 and 80 mg/200g BW (PLE-20, PLE-40, and PLE-80) and diclofenac sodium (Dic. sod. at a dose of 2.7 mg/200g BW as a positive control group was tested for antinociceptive and anti-inflammatory effects in experimental animal models (n=5). The effect of antinociceptive was evaluated by the wriggling in mice by acetic acid-induced, and the effect of acute anti-inflammatory was evaluated by carrageenan-induced in rats. Result: PLE at doses of 20, 40, and 80 mg/200g BW showed a significant antinociceptive effect at acetic acid-induced wriggling and inhibition of the oedema. Higher doses lead to more pronounced effects. The greater effect of antinociceptive was observed at PLE-80 (64.55%), and inhibition of the oedema was observed at PLE-80 (34.33%). Conclusion: PLE significantly reduced pain and acute inflammation in the animal-tested models.

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Phytochemical Screening, Antioxidant Activity, and Anti- Inflammatory Potential of Rhinachantus nasutus (L.) Kurz Flower Ethanol Extract

Cited by 4 publications

References 17 publications

The Ethanolic Extract of Rhinachantus nasutus (L.) Kurz Flower has Antioxidant, Anti-Gout, and Antibacterial Potential

The Ethanolic Extract of Rhinachantus nasutus (L.) Kurz Flower has Antioxidant, Anti-Gout, and Antibacterial Potential

Chisocheton pentandrus (Blanco) Merr. leaf as a potential antioxidant and α-glucosidase inhibitory agent

Antinociceptive and anti-inflammatory effect of Passiflora edulis leaves extract in acetic acid-induced pain and carrageenan-induced paw oedema in vivo

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