Phytochemical screening and Total Phenolics of Stem and Leaf extracts of Sandoricum koetjape

Saadah, Susy; Tulandi, Silvester Maximus

doi:10.30997/jah.v6i2.3156

Cited by 2 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bioactivities of S. koetjape have been previously reported. The total phenol content in the stems and leaves of S. koetjape was 1.4155 mg/g and 3.1469 mg/g, respectively (Saadah and Tulandi 2020). The seed extract of S. koetjape has inhibitory activity against P-388 leukemia cells (Bumi et al 2019).…”

Section: Introductionmentioning

confidence: 96%

Phytochemical and gas chromatography-mass spectrometry profiling of two plant parts of Sandoricum koetjape

SAADAH¹,

TULANDI²,

ROHMAN³

2022

Biodiversitas

View full text Add to dashboard Cite

Abstract. Saadah S, Tulandi SM, Rohman RA. 2022. Phytochemical and gas chromatography-mass spectrometry profiling of two plant parts of Sandoricum koetjape. Biodiversitas 23: 6199-6207. Sandoricum koetjape has been used in traditional Indonesian medicine for centuries. In Indonesia, the stem and leaves were used to treat helminthiasis, cough, stomachache, diarrhea, bloating, leucorrhoea, colic, and fever. To ascertain the phytochemical constituents of each plant part, and provide a sufficient basis for clinical application, so Gas Chromatography-Mass Spectrometry (GC/MS) analysis of stems and leaves was established. Phytochemical screening showed that stems and leaves contained alkaloids, flavonoids, quinone, triterpenoids, and tannin. Total phenolics in the leaves are higher than in the stem. Saponin and steroids were not detected. The GC/MS analysis indicated that the leaf extract contained more identified compounds (30) than the stem extract (28). Both S. koetjape samples contained 1H-Cycloprop[e]azulen-7-ol. The major compounds of the stem extract of S. koetjape are Fonenol (12.89%), 1H-Cyclopenta[1,3]cyclopropa[1,2]benzene (12.54%), and 1H-Cycloprop[e]azulen-7-ol (11.70%), while the major compounds in leaf methanol extract were 14,15-didehydro-Cyclodecacyclotetradecene (23.71%), 1H-Cycloprop[e]azulen-7-ol (17.04%), and Solanesol (8.34%). The two main components of the variable can account for 50.92% of the total variance, according to Principal Component Analysis (PCA) (PC1 is 21.19% and PC2 is 29.74%). These results indicate that the two components effectively categorize samples with distinct characteristics. The groups were divided based on the type of sample used, namely stem and leaf samples. According to the loading plot, 1H Cyclopenta[1,3]cyclopropa[1,2]benzene and Fonenol are two components that are very effective in categorizing samples based on their type. Both metabolites are higher in the stem than in the leaf. However, the metabolites activities of S. koetjape stem and leaves extracts could be revealed by further studies using in silico and in vitro approaches.

show abstract

Section: Introductionmentioning

confidence: 96%

Phytochemical and gas chromatography-mass spectrometry profiling of two plant parts of Sandoricum koetjape

SAADAH¹,

TULANDI²,

ROHMAN³

2022

Biodiversitas

View full text Add to dashboard Cite

show abstract

“…Numerous research investigations on plants for medicinal purposes have been carried out to verify and figure out their therapeutic properties and mechanism of action through evidence from science [1]. According to phytochemical screening, Sandoricum koetjape stems contained alkaloids, flavonoids, quinone, triterpenoids, and tannin [4]. The major volatile compounds in Sandoricum koetjape stem extract were fonenol, 1H-cycloprop[e]azule-7-ol, and 1-H-Cyclopenta [1,2]benzene [5].…”

Section: Introductionmentioning

confidence: 99%

Seven types of phenolic acid and inhibitory activity for protein tyrosine phosphatase 1B (PTP1B) from the stem of Sandoricum koetjape

Saadah,

Tulandi,

Rohman

2023

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

Sandoricum koetjapehas been traditionally used in Indonesian medicine for generations. The stem was used as a remedy for helminthiasis, sneezing, stomachache, indigestion, abdominal pain, leucorrhea, colic, and fever in Indonesia. The purpose of this study was to identify the phenolic acids found in the stem ofS. koetjapeand to test their ability to inhibit the protein tyrosine phosphatase 1B (PTP1B). P-coumaric acid, caffeic acid, ferulic acid, chlorogenic acid, syringic acid, 4-hydroxybenzoic acid, and gallic acid were identified as phenolic acids found in theS. koetjapestem. The interaction of phenolic acids with the PTP1B was predicted using molecular docking. PTP1B has been linked to diabetes, obesity, tumors, and Alzheimer’s. The autodock 4.2 program, which is integrated with the pyrx v.09.8 virtual screening tool, was used to conduct the docking studies. Interacting between p-coumaric acid with PTP1-B on amino acids Glu115, Lys116, Lys120, Cys215, Ala217, Gly218, Ile219, Gly220, and Arg221. P-coumaric acid fulfills Lipinski’s rule and therefore can be taken orally. P-coumaric acid is expected to have a high oral bioavailability in humans, great absorption in the intestine, and an equivalent distribution in blood plasma and intestine. P-coumaric acid’s acute toxicity is also expected to be low. P-coumaric acid is also non-toxic to the liver, immune system, mutagenic, and cytotoxic.Sandoricum koetjapephenolic acids, particularly p-coumaric acid, appeared to be an effective PTP1-B inhibitor based on docking results.

show abstract

Phytochemical screening and Total Phenolics of Stem and Leaf extracts of Sandoricum koetjape

Cited by 2 publications

References 3 publications

Phytochemical and gas chromatography-mass spectrometry profiling of two plant parts of Sandoricum koetjape

Phytochemical and gas chromatography-mass spectrometry profiling of two plant parts of Sandoricum koetjape

Seven types of phenolic acid and inhibitory activity for protein tyrosine phosphatase 1B (PTP1B) from the stem of Sandoricum koetjape

Contact Info

Product

Resources

About