Phytochemical Screening and Evaluation of Analgesic and Anti-inflammatory Activities of the Methanol Leaf Extract of Cissus polyantha

Sani, Yahaya Muhammad; Musa, A. M.; Yaro, Alpha Seydou; Sani, M B; Amoley, A.; Magaji, Mohammed Garba

doi:10.3923/jms.2013.824.828

Cited by 7 publications

(9 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cissus polyantha is one of those herbs traditionally used to treat diabetes. Phytochemical screening revealed that its leaves contain phenols, flavonoids, tannins, alkaloids, anthraquinones, steroids, carbohydrates, and glycosides [10]. The objective of this work was to determine the inhibitory properties of the aqueous extract of the leafy stems of Cissus polyantha on the activity of two digestive enzymes and to evaluate its antioxidant potential.…”

Section: Discussionmentioning

confidence: 99%

“…Cissus polyantha (Vitaceae) is used in northern Nigeria as an antimicrobial and analgesic [8], in Liberia for the treatment of conjunctivitis [9], and in Cameroon for cure diarrheal diseases and diabetes. Qualitative phytochemical studies have reported that C. polyantha leaves contains quinoids, sterols, terpenes, saponins, phenols, tannins, and flavonoids [10]. The present study aims to quantify the polyphenols, flavonoids, and tannins in the aqueous extract from leafy stems of Cissus polyantha , to determine its antioxidant potential and to evaluate its inhibitory properties on the α -amylase and α -glucosidase activities.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant Properties and Digestive Enzyme Inhibitory Activity of the Aqueous Extract from Leafy Stems of Cissus polyantha

Talba

Miaffo

Kamani

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Cissus polyantha (Vitaceae) is a plant used in Cameroonian traditional medicine for the treatment of diabetes. The aims of this study were to evaluate the in vitro antioxidant and antidiabetic activities of the aqueous extract of Cissus polyantha leafy stems. The enzyme inhibitory activity was determined in vitro on α-amylase and α-glucosidase enzymes, followed by confirmative study in vivo on normal rats (oral starch and sucrose tolerance tests at doses of 111, 222, and 444 mg/kg). The ferric reducing antioxidant power and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) antiradical activity of the extract were examined to evaluate the antioxidant potential of the extract. The total content of phenols, flavonoids, and tannins of the extract were also determined. The results showed an inhibitory effect of the extract on the α-amylase and α-glucosidase activities with IC50 values of 216.14 and 182.40 μg/mL, respectively. The extract at doses of 222 and 444 mg/kg induced a significant decrease in postprandial glycaemia during the starch and sucrose tolerance tests. A remarkable antiradical activity of the extract was obtained although lower than that of the standard product. The aqueous extract of leafy stems of Cissus polyantha has an interesting inhibitory activity on the α-amylase and α-glucosidase enzymes, as well as an antioxidant potential, thus validating its use in traditional medicine for the treatment of diabetes mellitus and its complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant Properties and Digestive Enzyme Inhibitory Activity of the Aqueous Extract from Leafy Stems of Cissus polyantha

Talba

Miaffo

Kamani

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…The findings include the presence of alkaloids, flavonoids, tannins, saponins and triterpenoids. There is documented evidence that plants with a combination of secondary metabolites such as alkaloids, flavonoids and saponins possess significant analgesic activities 14,15 Prostaglandin synthases; suggestive of anti-pyretic activities 16,17 .…”

Section: Discussionmentioning

confidence: 99%

Analgesic and Anti-Pyretic Activities of the Root Bark of Rutidea Parviflora (Rubiaceae)

Rosa

Agborubere

Godwin

2021

JAPST

View full text Add to dashboard Cite

This study aims at investigating the antipyretic activity of different solvent fractions of the root bark of Rutidea parviflora (Rubiaceae). This plant is used ethno-botanically by the people of Ethiope East-West Local Government Area of Delta State, Nigeria to treat various ailments such as inflammation, fever and pain. This necessitated this research to validate its local use, due to the scanty literature and information present about this plant. It has also shown some anti-cancer and anti-inflammatory activity in previous researches. The present study is a randomized control study. Acetic acid induced writhing was employed for analgesic testing. Acetic acid was used to induce writhing in Wistar rats which were divided into fourteen (14) groups. The groups were administered extracts and fractions of the plant (200 mg/kg and 400 mg/kg). The animals were observed for number of writing movements and the percentage writhing was calculated. Baker’s yeast induced pyrexia was employed for the antipyretic testing. The animal groups were administered extracts and fractions of the plant (200 mg/kg and 400 mg/kg), with Paracetamol as the standard drug (100 mg/kg) and Normal saline (control) for both experiments. The body temperature of the rats was measured rectally over a period of five (5) hours. All values of P<0.05 were taken as significant. The organic extract, aqueous extract and various fractions (n-hexane, ethyl-acetate, n-butanol and aqueous) produced significant inhibition of writhing responses and pyrexia in a dose dependent manner and time dependent manner respectively. The aqueous extract at a dose of 400mg/kg showed the greatest reduction in writhing, 91.58% compared to the standard drug (paracetamol) which may suggest that the fraction possesses better efficacy than paracetamol as an analgesic. The observed activities could be attributed to these bioactive compounds: Palmatine, Urs-12-ene-24-oic-3-oxo-methyl ester and Gallic acid contained in R. parviflora.

show abstract

“…Plants containing organic acid, saponins,alkaloids and flavonoids are known to show significant analgesic activities. Flavonoids and alkaloids inhibit prostaglandins involved in pain perception [38,39] .…”

Section: Discussionmentioning

confidence: 99%

“…The qualitative phytochemical screening of dichloromethane stem bark extract of A. mellifera indicated the presence of flavonoids, steroids, alkaloids, saponins, cardiac glycosides, phenolics, terpenoids and tannins. These phytochemicals are associated with good antiinflammatory, analgesic and antipyretic potential [33,38,39,44,49] . Therefore, the antiinflammatory, analgesic and antipyretic activities of the stem bark extract of A. mellifera could be due to the overall effect of the plant constituents.…”

Section: Discussionmentioning

confidence: 99%

Antiinflammatory, analgesic and antipyretic effects of dichloromethane stem bark extract of Acacia mellifera

Veronica¹,

Cheruiyot²,

Bosibori³

et al. 2017

J Phytopharmacol

View full text Add to dashboard Cite

The present study was designed to assess the in vivo antiinflammatory, analgesic and antipyretic effect of the dichloromethane stem bark extract of Acacia mellifera on experimental animal model at three different dose levels of 50, 100 and 150mg/kg body weight respectively. In addition, phytochemical screening of the extract was done. The inflammatory effect was evaluated by use of carragenaan-induced paw edema in mice, pain was determined using formalin-induced writhing in mice and pyrexia was determined by turpentine-induced pyrexia in rats. The activity of the herbal extract was compared to diclofenac sodium and aspirin. The phytochemical analysis showed the presence of alkaloids, cardiac glycosides, flavonoid, saponins, steroids, terpenoids, tannins and phenolics. The plant extract produced marked anti-inflammatory effect in carrageenaninduced mice paw edema assay, suppressed licking response of animals in both phases of the formalin- induced test and exhibited appreciable antipyretic effects in turpentine-induced pyrexia in rats. The study thus supports the folklore use of the plant in the treatment and management of inflammation, pain and pyrexia.

show abstract

Phytochemical Screening and Evaluation of Analgesic and Anti-inflammatory Activities of the Methanol Leaf Extract of Cissus polyantha

Cited by 7 publications

References 4 publications

Antioxidant Properties and Digestive Enzyme Inhibitory Activity of the Aqueous Extract from Leafy Stems of Cissus polyantha

Antioxidant Properties and Digestive Enzyme Inhibitory Activity of the Aqueous Extract from Leafy Stems of Cissus polyantha

Analgesic and Anti-Pyretic Activities of the Root Bark of Rutidea Parviflora (Rubiaceae)

Antiinflammatory, analgesic and antipyretic effects of dichloromethane stem bark extract of Acacia mellifera

Contact Info

Product

Resources

About