Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Effects of Leptopus Cordifolius Decne. In Diabetic Mice

Rahman, Shahid; Jan, Gul; Jan, Farzana Gul; Rahim, Hafeez Ur

doi:10.3389/fphar.2021.643242

Cited by 15 publications

(7 citation statements)

References 54 publications

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“…Due to their capacity to stimulate glycogenesis in the liver, release insulin from pancreatic β -cells, or inhibiting glucose absorption in the gut, the secondary metabolites that were found in C. coggygria extracts may be responsible for the antioxidant and observed glucose suppressive and antihyperglycemic activities [ 79 – 82 ]. Through a number of mechanisms, the utilization of these plants and phytoconstituents may prevent the onset of diabetic complications and regulate metabolic irregularities, which is in accordance with our previous research work [ 83 , 84 ]. In order to integrate plant medicines with high therapeutic effects to treat diabetes, these results stimulate future investigations of the extracts and identify particular active molecules engaged in various biological functions.…”

Section: Discussionsupporting

confidence: 89%

Phytochemical Investigation and Therapeutical Potential of Cotinus coggygria Scop. in Alloxan-Induced Diabetic Mice

Rahman

Jan

et al. 2022

Oxidative Medicine and Cellular Longevity

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Plants are a significant source for the development of new phytomedicines due to their great clinical benefits, efficiency, cost-effectiveness, fewer side effects, and more affordable therapies. Numerous plants used in traditional treatments, such as Cotinus coggygria Scop., have been effective in the treatment of diabetes mellitus (DM). Therefore, the study is aimed at assessing the phytochemical, antioxidant, and antidiabetic properties of C. coggygria. The hypoglycemic and hypolipidemic activity was evaluated in Swiss male Albino mice by administering an oral dose of 150-250 mg/kg of C. coggygria extracts in alloxan-induced diabetic mice for 15 days. The antioxidant activity and phytochemical composition of the extracts were assessed by using α, α diphenyl-β-picrylhydrazyl (DPPH) and hydrogen peroxide scavenging assays and through standard chemical procedures. The effects of extracts on blood glucose, body weight, lipid profile, and biochemical parameters like total cholesterol (TC), triglyceride (TG), low-density lipids (LDL), high-density lipids (HDL), plasma insulin, liver glycogen, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea, and creatinine were determined according to standard procedures. The activities of antioxidant enzymes such as superoxide-dismutase (SOD), peroxidase (POD), and catalase (CAT) were also analyzed spectrophotometrically. The hypoglycemic and hypolipidemic effects with chloroform extracts of 250 mg/kg were found significant in the treatment of diabetes in alloxanised mice compared to the diabetic group. The haematological parameters such as TC, TG, HDL, LDL, creatinine, urea, AST, ALT, and ALP were significantly improved ( p < 0.01 ) by the chloroform extract of 250 mg/kg compared to the diabetic group. Treatment for 15 days showed significant elevation ( p < 0.01 ) of antioxidant enzymes. Fourier-transform infrared spectroscopic (FTIR) and gas chromatography–mass spectrometry (GC-MS), column chromatography (CC), and nuclear magnetic resonance (NMR) analyses tentatively identified different phytoconstitutents and metabolites in C. coggygria leaves, which have been reported to possess antihyperglycemic properties. In conclusion, the chloroform extract of 250 mg/kg of C. coggygria possesses significant hypoglycemic and hypolipidemic potential which may prove the claimed use of the plant in amelioration of diabetes and associated complications in folkloric medicine. Additional studies are required for the purification, characterization, and structural elucidation of bioactive compounds.

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Section: Discussionsupporting

confidence: 89%

Phytochemical Investigation and Therapeutical Potential of Cotinus coggygria Scop. in Alloxan-Induced Diabetic Mice

Rahman

Jan

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Hyperglycemia is accompanied by a rise in TC, TG, and LDL, and a fall in HDL levels [18]. The methanolic extract L. cordifolius and gibenclamide might act on reserved fats and inhibit the release of free fatty acids, decreasing the total cholesterol and triglyceride levels, and increasing the HDL level as reported by Rahman et al, [19].…”

Section: Leptopopus Cordifolius Decnmentioning

confidence: 87%

Review of medicinal plant associated with antihyper-lipidermia

Irinmwinuwa¹,

Unekwe²,

Olanrewaju³

et al. 2022

Magna Sci. Adv. Res. Rev.

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Hyperlipidemia is a common disease around the world which has affected both developed and developing countries, in this disease blood level of lipids is elevated more than normal range. Elevated lipids levels (cholesterol, fats, and triglyceride) predispose the patient to various serious and sometimes lethal complications such as cardiovascular disease, cerebral strokes, hepatic and renal dysfunction. This review emphasizes on some plants (extracts) having anti-cholesterol actions, including; Glycyrrhiza glabra,Legenaria siceraria,Medicago sativa,Curcuma longa,Syzygium cerasoideum, Leptopus Cordifolius Decne, Piper longum, Moringa oleifera, Zingiber officinale, Trigonella foenum-graecum, Carum carvi, Carica papaya, Gloriosa superba, Ficus religiosa, Eleucine coracana, Lycium europaeum and Hibiscus sabdariffa for anti-hyperlipidemic potential. increase in the levels of these lipoproteins like, triglycerides (TG), Total cholesterol (TC), Very low density lipoprotein (VLDL) and low-density lipoprotein (LDL)includes some mechanisms of actions of these medicinal plants observed in triton-x, cholesterol, high fat diet, Poloxamer-407, Dexamethasone and alloxan-induced in-vivo and in-vitro models. Additionally, this review gives proof to the fact that these medicinal plants can be used for the management and prophylaxis of hyperlipidermia, thus reducing complications associated with hyperlipidermia.

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“…Leptopus cordifolius Decne. has a major toxin known as cicutoxin that causes muscle weakness, piloerection, bone lesions, aneurysms, and burning sensations ( Rahman et al, 2021 ). The Datura stramonium L. contains sopolamine and hyoscyamine, which cause dermatitis, polydipsia, mydriasis, anorexia, abdominal pain, stupefaction, and restlessness ( Murtala et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

An appraisal of traditional knowledge of plant poisoning of livestock and its validation through acute toxicity assay in rats

Rasool,

Nizamani,

Ahmad

et al. 2024

Front. Pharmacol.

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Background: Kashmir Himalaya hosts the most diverse and rich flora in the world, which serves as grazing land for millions of small ruminants in the area. While most plant species are beneficial, some can be poisonous, causing economic losses and animal health issues for livestock. Consequently, this study is the first comprehensive report on the traditional phyto-toxicological knowledge in District Muzaffarabad and the assessment of its authenticity through experimental studies in rats.Methods: The data regarding traditional knowledge was gathered from 70 key respondents through semi-structured interviews, which was quantitatively analyzed and authenticated through plant extract testing on Wistar female rats and comparison with published resources.Results: A total of 46 poisonous plant species belonging to 23 families and 38 genera were reported to be poisonous in the study area. Results revealed that leaves were the most toxic plant parts (24 species, 52.1%), followed by the whole plant (18 species, 39.1%), stem (17 species, 36.9%), and seeds (10 species, 21.7%). At the organ level, liver as most susceptible affected by 13 species (28.2%), followed by the gastrointestinal tract (15 species, 32.6%), nervous system (13 species, 8.2%), dermis (8 species, 17.3%), renal (7 species, 15.2%), respiratory (4 species, 8.7%), cardiovascular system (3 species, 6.5%), and reproductive system (2 species, 4.3%). The poisonous plant species with high Relative frequency citation (RFC) and fidelity level (FL) were Nerium oleander (RFC, 0.6; FL, 100), Lantana camara (RFC, 0.6; FL, 100), and Ricinus communis (RFC, 0.6; FL, 100). Experimental assessment of acute toxicity assay in rats revealed that Nerium oleander was the most toxic plant with LD50 of (4,000 mg/kg), trailed by Ricinus communis (4,200 mg/kg), L. camara (4,500 mg/kg), and Datura stramonium (4,700 mg/kg); however, other plants showed moderate to mild toxicity. The major clinical observations were anorexia, piloerection, dyspnea, salivation, tachypnea, constipation, diarrhea, tremor, itchiness, and dullness.Conclusion: This study showed that numerous poisonous plants pose a significant risk to the livestock industry within Himalayan territory, leading to substantial economic losses. Consequently, it is of utmost importance to conduct further comprehensive studies on the phytotoxicity of plants.

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Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Effects of Leptopus Cordifolius Decne. In Diabetic Mice

Cited by 15 publications

References 54 publications

Phytochemical Investigation and Therapeutical Potential of Cotinus coggygria Scop. in Alloxan-Induced Diabetic Mice

Phytochemical Investigation and Therapeutical Potential of Cotinus coggygria Scop. in Alloxan-Induced Diabetic Mice

Review of medicinal plant associated with antihyper-lipidermia

An appraisal of traditional knowledge of plant poisoning of livestock and its validation through acute toxicity assay in rats

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