Phytochemical profile, anti-inflammatory, antimutagenic and antioxidant properties of Acrocomia aculeata (Jacq.) Lodd. pulp oil

Costa, Gleicieli Libório Alencar; Buccini, Danieli Fernanda; Arruda, Ana Lúcia Alves de; Favaro, S. P.; Moreno, Susana Elisa

doi:10.1590/fst.25319

Cited by 23 publications

(23 citation statements)

References 55 publications

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“…Studies have found that many plants contain the ingredients which have good activities in antioxidant, anti-inflammatory, anti-tumor and other aspects (Costa et al, 2020;Huang et al, 2020;Santos et al, 2021). Curcumol is a sesquiterpene compound isolated from the zedoary turmeric oil which has long been used as a folk medicine in China for many years (You et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

[RETRACTED ARTICLE]Isolation of curcumol from zedoary turmeric oil and its inhibitory effect on growth of human hepatocellular carcinoma xenografts in nude mice

2022

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This study investigated the inhibitory effect and mechanism of curcumol on growth of human hepatocellular carcinoma (HCC) HepG2 xenografts in nude mice. Curcumol was isolated from from zedoary turmeric oil. The HepG2 xenograft model in nude mice was established. Forty modeled nude mice were divided into model, cisplatin, curcumol and cisplatin+curcumol groups. The latter three groups were treated with 2 mg/kg cisplatin, 100 mg/kg curcumol and 2 mg/kg cisplatin combined with 100 mg/kg curcumol, respectively, once every two days, for total seven times. After treatment, compared with cisplatin group, in cisplatin+curcumol group the tumor weight and tumor inhibition rate were obviously increased, the apoptosis rate of HepG2 cells was obviously increased, the expression levels of Caspase-3 and B-cell lymphoma-2 associated X proteins in xenograft tumor were significantly increased, and the expression level of B-cell lymphoma-2 protein was significantly decreased. In addition, the thymus index and spleen index of animal had no significant difference between cisplatin group and cisplatin+curcumol group. In conclusion, the additional use of curcumol can obviously increase the inhibitory effect of cisplatin on growth of HCC HepG2 xenografts in nude mice. The mechanism may be related to the enhanced promotion of apoptosis of tumor.

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Section: Introductionmentioning

confidence: 99%

[RETRACTED ARTICLE]Isolation of curcumol from zedoary turmeric oil and its inhibitory effect on growth of human hepatocellular carcinoma xenografts in nude mice

2022

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“…The main mechanism is that there is a significant difference in the pattern of gene expression in the tumor tissue of the patients with prostate cancer and lymph node metastasis, and the patients with prostate cancer have more adverse gene up-regulation than those with lymph node metastasis. alpha -catenin) is decreased, and subsequently, promoting the invasion of cells and the swelling of the cells (Wang et al, 2011;Demirkol et al, 2020;Costa et al, 2020;Mostafa et al, 2021). ACP5 gene expressed tartaric acid resistant acid phosphatase -5a/b, bone resorption osteoclasts, macrophages and dendritic cells can synthesize and secrete TRACP, osteoclasts only secrete 5b, macrophages and dendritic cells only secrete 5A.…”

Section: Discussionmentioning

confidence: 99%

Clinical prognosis and gene expression profiles of prostate cancer patients with bone and lymphatic metastases

et al. 2022

Food Sci. Technol

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“…Formononetin can prevent the myocardial from ischemia-reperfusion injury in rats by suppressing the ROS-TXNIP-NLRP3 pathway (Wang et al, 2020). It is found that many plants or their extracts have the antioxidant, anti-inflammatory and other activities (Costa et al, 2020;Hu et al, 2021;Sultan et al, 2021). This study was to investigate the effect of formononetin from Trifolium pratense L. on oxidative stress, energy metabolism and inflammatory response after CIRI in mice.…”

Section: Introductionmentioning

confidence: 99%

Effect of formononetin from Trifolium pratense L. on oxidative stress, energy metabolism and inflammatory response after cerebral ischemia-reperfusion injury in mice

Wang

Dong

2022

Food Sci. Technol

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Cerebral ischemia-reperfusion injury (CIRI) is one of the main diseases leading to death and disability. Studying the role and mechanism of drugs in mitigating CIRI is of great significance. In the present study, the effect of formononetin from Trifolium pratense L. on oxidative stress, energy metabolism impairment and inflammatory response after cerebral ischemia-reperfusion injury (CIRI) in mice were investigated. Formononetin was extracted from Trifolium pratense L. and was purified. The mice were treated with formononetin for six days. Then, the CIRI model was established. After 24 h of reperfusion, compared with model group, in formononetin group, the neurological deficit score, cerebral water content and cerebral infarction rate were significantly decreased, the brain tissue nitric oxide and malondialdehyde levels were significantly decreased, the brain tissue superoxide dismutase level was significantly increased, the brain tissue Na + -K + -ATPase, Ca 2+ -Mg 2+ -ATPase and Ca 2+ -ATPase activities were significantly increased, and the brain tissue tumor necrosis factor α, interleukin 1β and interleukin 6 levels were significantly decreased. In conclusion, formononetin from Trifolium pratense L. can reduce the oxidative stress, energy metabolism impairment and inflammatory response in brain tissues, thus mitigating the CIRI in mice.

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Phytochemical profile, anti-inflammatory, antimutagenic and antioxidant properties of Acrocomia aculeata (Jacq.) Lodd. pulp oil

Cited by 23 publications

References 55 publications

[RETRACTED ARTICLE]Isolation of curcumol from zedoary turmeric oil and its inhibitory effect on growth of human hepatocellular carcinoma xenografts in nude mice

[RETRACTED ARTICLE]Isolation of curcumol from zedoary turmeric oil and its inhibitory effect on growth of human hepatocellular carcinoma xenografts in nude mice

Clinical prognosis and gene expression profiles of prostate cancer patients with bone and lymphatic metastases

Effect of formononetin from Trifolium pratense L. on oxidative stress, energy metabolism and inflammatory response after cerebral ischemia-reperfusion injury in mice

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