Phytochemical profile and mechanisms involved in the anti-nociception caused by the hydroethanolic extract obtained from Tocoyena formosa (Cham. &amp; Schltdl.) K. Schum (Jenipapo-bravo) leaves in mice

Cesário, Francisco Rafael Alves Santana; Albuquerque, Thaís Rodrigues de; Lacerda, Giovana Mendes de; Oliveira, Maria Rayane Correia de; Rodrigues, Lindaiane Bezerra; Martins, Anita Oliveira Brito Pereira Bezerra; Boligon, Aline Augusti; Quintans‐Júnior, Lucindo José; Araújo, Adriano Antunes de Souza; Vale, Mariana Lima; Coutinho, Henrique Douglas Melo; Menezes, Irwin Rose Alencar de

doi:10.1016/j.biopha.2017.10.054

Cited by 11 publications

(6 citation statements)

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“…K. Schum (HELTF) allowed the identification of secondary metabolites, as shown in Table 1. HPLC fingerprinting of HELTF, just previously published, revealed the presence of the gallic acid, catechin, chlorogenic acid, caffeic acid, ellagic acid, rutin, quercetin and luteolin (Cesário et al, 2018), however, Chlorogenic acid (21.73 mg/g), Caffeic acid (13.86 mg/g), Quercetin (17.54 mg/g) and Luteolin (25.09 mg/g) are major compounds present in extract. This result confirms a secondary metabolite identified in qualitative phytochemical prospecting showed in Table 1.…”

Section: Resultsmentioning

confidence: 87%

“…There are some reports in the literature about the chemical composition of Tocoyena formosa species just previously published by Cesário et al (2018). They were isolated chemical constituents as saponin (3-O-beta-D-glucopyranosyl-28-O-b-D-glucopyranosyl-quinovic); flavonoid (3-O-beta-D-ramnosyl-3-O-methylquercetin); iridoids (α and β Gardiol and genipin) (Da S. Bolzani et al, 1997, Hamerski et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

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Chemical fingerprint, acute oral toxicity and anti-inflammatory activity of the hydroalcoholic extract of leaves from Tocoyena formosa (Cham. & Schlecht.) K. Schum

Cesário

Albuquerque

Lacerda

et al. 2019

Saudi Journal of Biological Sciences

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Inflammation is a protective response of the organism against damaging agents, this process is considered beneficial, however in some situations, this response can be damage when exacerbated effect are present. This claim objective to evaluate the qualitative and quantitative chemical profile, acute toxic and anti-inflammatory effects of the hydroalcoholic extract of leaves from Tocoyena formosa (Cham. & Schlecht.) K. Schum . (HELTF). Quantitative and qualitative phytochemical analysis was performed by HPLC-DAD and colorimetric assay. The topical anti-inflammatory activity was determined in Croton oil-induced ear edema assay and systemic activity was performed in vascular permeability, paw edema induced by carrageenan and dextran. Phytochemical analysis of leaves from HELTF showed presence of tannin, flavonoid, saponins an other that confirmed by HPLC analysis. The extract did not cause significant with LD 50 greater than 5000 mg/kg and did not promote significate reduction in topical inflammatory process. However, HELTF demonstrate significant reduction of paw edema induced by carrageenan and dextran. The HELTF (200 mg/kg) reduced the protein/cell migration in the intradermal carrageenan-induced inflammation. Our results demonstrated that the first time the chemical profile and describe the effective action in systemic anti-inflammatory, antiedematogenic activity and low acute toxicity. This activity presents, supporting its traditional use. However, new studies are necessary for the detection and clarification of the possible mechanism of action.

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Section: Resultsmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Chemical fingerprint, acute oral toxicity and anti-inflammatory activity of the hydroalcoholic extract of leaves from Tocoyena formosa (Cham. & Schlecht.) K. Schum

Cesário

Albuquerque

Lacerda

et al. 2019

Saudi Journal of Biological Sciences

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“…Although there is no direct evidence for the gastroprotector activity of Ximenia americana and Ziziphus joazeiro , its use by the community for this therapeutic purpose may correlate with its anti-inflammatory, cicatrizing, and antioxidant potential [96, 98, 99]. Studies have shown that Tocoyena formosa has anti-inflammatory [100], antinociceptive [101], and gastroprotective activities [102]. …”

Section: Resultsmentioning

confidence: 99%

Analysis of the Variability of Therapeutic Indications of Medicinal Species in the Northeast of Brazil: Comparative Study

Macedo

Menezes

Ribeiro

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Ethnopharmacological Relevance This study aims to evaluate the versatility of these species and their agreement of use and/or the informants' knowledge and verify the variability of the information on the indicated medicinal species in comparison to other species from northeastern Brazilian areas. Materials and Methods Ethnobotanical information was acquired through interviews with 23 residents of the Quincuncá community, northeastern Brazil. From the obtained data, a comparative analysis of the therapeutic indications with other 40 areas in different biomes was conducted. For that, the relative importance index and informant consensus factor were calculated and compared to other indices evaluated in the literature. Results A total of 39 medicinal species were cited and twenty-six species showed similarities among their therapeutic indications; however, species as Geoffroea spinosa, Lantana camara, and others can be highlighted, present in community disease indications that were not verified for other areas. Myracrodruon urundeuva, Mimosa tenuiflora, Stryphnodendron rotundifolium, and Amburana cearensis had the greatest versatility. In the Quincuncá community, medicinal species were indicated for 49 diseases, which were grouped into 15 categories of body systems. Conclusion This study shows the presented divergence in relation to their therapeutic use; in this point, these divergences reinforce the importance of pharmacological research.

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“…Gallic acid, or 3,4,5-trihydroxybenzoic acid, is a secondary metabolite present in most tall plants and can be found in isolated form or complexed with other compounds (Daglia et al 2014;Fernandes and Salgado 2016). Along with its derivatives, it occurs in various parts of the plant, and is known for its antioxidant activity, but also can have anti-inflammatory, antinociceptive, anticancer and antimicrobial activity (Boeira et al 2011;Daglia et al 2014;Kumar and Jain 2014;Raafat and Samy 2014;Saad et al 2014;Trevisan et al 2014;Mard et al 2015;Pandurangan et al 2015;Fernandes and Salgado 2016;BenSaad et al 2017;Cesário et al 2018). Its (Trevisan et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation

et al. 2022

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The oil of Caryocar villosum is used in Amazonian folk medicine to treat pain and inflammatory conditions. So, we assessed the anti-inflammatory and antinociceptive properties of the ethanolic extract obtained from the fruit peels of this species. The acetic acid-induced writhing, carrageenan-induced mechanical hyperalgesia, formalin, carrageenan-induced paw edema and carrageenan-induced peritonitis tests were used on mice. The C. villosum ethanolic extract significantly inhibited the number of abdominal writhes, mechanical hyperalgesia and paw licking time in the second phase of the formalin test. At a dose of 300 mg kg-1, the extract also significantly reduced the volume of edema formed in the late phase and reduced the recruitment of leukocytes and neutrophils in the peritoneal cavity, as well as CXCL1 chemokine levels. It is suggested that the extract attenuates the leukocyte recruitment by inhibiting the CXCL1 activation. The peripheral antinociceptive activity occured through opioid pathway modulation because pretreatment with C. villosum ethanolic extract reversed the naltrexone-induced antinociception.

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Phytochemical profile and mechanisms involved in the anti-nociception caused by the hydroethanolic extract obtained from Tocoyena formosa (Cham. & Schltdl.) K. Schum (Jenipapo-bravo) leaves in mice

Cited by 11 publications

References 50 publications

Chemical fingerprint, acute oral toxicity and anti-inflammatory activity of the hydroalcoholic extract of leaves from Tocoyena formosa (Cham. & Schlecht.) K. Schum

Chemical fingerprint, acute oral toxicity and anti-inflammatory activity of the hydroalcoholic extract of leaves from Tocoyena formosa (Cham. & Schlecht.) K. Schum

Analysis of the Variability of Therapeutic Indications of Medicinal Species in the Northeast of Brazil: Comparative Study

Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation

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