CHEMICAL COMPOSITION AND ANTI-LEISHMANIA ACTIVITY FROM Tocoyena hispidula. Phytochemical investigation of the CHCl 3 fraction from EtOH extract of Tocoyena hispidula (Rubiaceae) stem resulted in the isolation and identification of D-(+)-mannitol, lupenone, 3-O-acetyloleanolic acid, lapachol, dimethyl chelidonate, morindolide and four mixtures (M1-M4): M1 (palmitate, margarate, linoleate, oleate e stearate of the multiflorenyl, lupeyl, sitosteryl and stigmasteryl), M2 (lupeol, taraxerol, germanicol, β-amyrin and E-fitol), M3 (campesterol, campestanol, stigmasterol, Δ 22-stigmastenol, sitosterol and sitostanol) and M4 (7-ketositosterol and 7-ketostigmasterol). Structural identification of the compounds was performed by analysis 1 H and 13 C NMR spectra and by GC-MS. Extract, fractions, dimethyl chelidonate and morindolide inhibited the growth of Leishmania major promastigotes, being the CHCl 3 (IC 50 = 26.25 μg mL-1) and EtOAc (IC 50 = 29.77 μg mL-1) fractions the more active.