Phytochemical profile and anti-Candida and cytotoxic potential of Anacardium occidentale L. (cashew tree)

Costa, Adrielle Rodrigues; Almeida-Bezerra, José Weverton; Silva, Teresinha Gonçalves da; Pereira, Pedro Silvino; Borba, Elizabeth Fernanda de Oliveira; Braga, Ana Lays; Fonseca, Victor Juno Alencar; Menezes, Saulo Almeida de; Silva, Francisco Sydney Henrique da; Fernandes, Priscilla Augusta de Sousa; Oliveira, Maraiza Gregorio de; Oliveira, Thalyta Julyanne Silva de; Tavares, A.; Brito, Edy Sousa de; Ribeiro, Paulo Riceli Vasconcelos; Santos, Luciano Temoteo dos; Santos, Antônia Thassya Lucas dos; Morais-Braga, Maria Flaviana Bezerra; Sampaio, Raimundo Samuel Leite; Cruz, Rafael Pereira da; Duarte, Antônia Eliene; Barros, Luiz Marivando

doi:10.1016/j.bcab.2021.102192

Cited by 11 publications

(13 citation statements)

References 63 publications

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“…Infelizmente o desenvolvimento de novos antifúngicos é bastante limitado devido à natureza das células, pois tanto as leveduras quanto as células do seu hospedeiro são eucarióticas (Roemer;Krysan, 2014;Nicola et al, 2019). Como alternativa, pesquisas visam combinar produtos naturais e antifúngicos, a fim de avaliar se os produtos naturais são capazes de intensificar a ação dos fármacos (Bezerra et al, 2019;Costa et al, 2021;Rodrigues et al, 2022). estudos buscam responder pelo menos uma das perguntas a seguir: "quem são?…”

Section: Fungosunclassified

Microbiologia avançada: perspectivas atuais e futuras

Almeida-Bezerra,

Coutinho

2024

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Section: Fungosunclassified

Microbiologia avançada: perspectivas atuais e futuras

Almeida-Bezerra,

Coutinho

2024

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“…Little information has been described with respect to the antifungal activity of A. occidentale. Some studies have shown the MIC ranges between 400 and 2000 μg/mL against C. albicans [9,12,45,49]. Other research has reported no activity against C. albicans [9].…”

Section: Antifungal Activity Of a Occidentale Leaf Extract Against Ca...mentioning

confidence: 99%

Unmasking Antifungal Might: Anacardium occidentale Leaf Extract Unleashes Mitochondrial Disruption, Thwarting Candida albicans with Heightened Reactive Oxygen Species

Quejada,

Hernandez,

Chitiva

et al. 2024

Preprint

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Invasive fungal disease causes high morbidity and mortality among immunocompromised patients. Anti-fungal drug resistance and cytotoxicity highlight the need for effective antifungal therapeutics. In this study, the antifungal potential of the ethanolic extract of Anacardium occidentale (Cashew Leaf) leaves were evaluated against Candida albicans and C. auris. The antifungal activity was tested by the broth microdilution method and growth kinetic test. To further explore its antifungal action mode, spectrofluorophotometry, confocal microscopy and scanning and transmission electron microscopy were performed, Additionally, heterozygous knockout strains associated with resistance to oxidative stress were included in the study. We found that A. occidentale could inhibit the proliferation and growth of C. albicans at concentrations of 62.5 and 125 μg/mL. the doubling time was also drastically affected, going from 2.8 hours to 22.5 hours. Which was also observed in C. auris. The extract induced the accumulation of intracellular reactive oxygen species (ROS), resulting in endoplasmic reticulum stress and mitochondrial dysfunction, while it did not show cy-totoxicity or hemolytic activity at the concentrations evaluated. Our work preliminarily elucidated the po-tential mechanisms of A. occidentale against C. albicans on a cellular level and might provide a promising op-tion for the design of a new treatment for invasive candidiasis

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“…Na medicina popular, as folhas e cascas são utilizadas para tratar diabetes, úlceras e câncer (Taiwo et al, 2017), a literatura aponta atividade antifúngica e citotóxica para o extrato da casca do cajueiro destacando sua composição rica em ácido gálico (Costa et al, 2021), além de que o pseudofruto também apresenta rica composição fenólica livre, com presença de atividade antimicrobiana e antioxidante (Sruthi, Roopavathi, Naidu, 2023).…”

Section: Anacardium Occidentale Lunclassified