Phytochemical, pharmacological, and In-silico molecular docking studies of Strobilanthes glutinosus Nees: An unexplored source of bioactive compounds

Aziz, Marya; Ahmad, Saeed; Iqbal, Muhammad; Khurshid, Umair; Saleem, Hammad; Khan, Kashif-ur-Rehman; Alamri, Abdulwahab; Anwar, Sirajudheen; Alamri, Abdulhakeem S.; Chohan, Tahir Ali

doi:10.1016/j.sajb.2021.07.013

Cited by 16 publications

(7 citation statements)

References 23 publications

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“…The qualitative results of S. cordifolia were compared with Strobilanthes glutinosus, and it was confirmed that both plants contain bioactive compounds confirmed. [41] The UV visible spectrum of extracted ZnONPs from S. cordifolia with absorbance at 362 nm was compared to that of Suaeda japonica leaf extract revealed that their results are in accordance with our results. [42] Similarly, [43] observed a strong blue band at 362 nm in Acalypha indica studies on zinc oxide nanoparticles, which resulted from defects in the zinc oxide crystal structure.…”

Section: Discussionsupporting

confidence: 87%

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Kirubakaran,

Selvam,

Subramanian Shivakumar

et al. 2024

ChemistrySelect

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Strobilanthes cordifolia has emerged as a promising material in traditional medicine. In this study, we have made an attempt to synthesize zinc oxide nanoparticles derived from S. cordifolia leaf. The team employed a wide range of techniques including UV, FT‐IR, XRD, FE‐SEM with EDAX, HR‐TEM with SAED, DLS, Zeta potential, BET and PZC analysis to thoroughly examine the properties of the NPs. FTIR analysis provided evidence of various functional groups within the NPs. XRD analysis demonstrated the crystal nature and phase purity of the NPs. SEM analysis showcased the spherical shape of the particles, while TEM revealed their rod‐like shape with sizes averaging at approximately 10 nm. DLS analysis indicated the average particle size, and the high zeta potential value confirmed the stability and BET analysis deciphered the specific surface area of the biosynthesized NPs. The NPs confirmed strong antioxidant properties with DPPH, ABTS, and hydroxyl radicals. Enzyme studies confirmed good anti‐cholinergic activity and anti‐inflammatory efficacy, highlighting their potential therapeutic benefits. The NPs demonstrated promising wound healing properties. Overall, this research study sheds light on the medicinal aspects of zinc oxide nanoparticles from S. cordifolia leaf extract and it offers exciting prospects for future exploration and development in this field.

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Section: Discussionsupporting

confidence: 87%

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Kirubakaran,

Selvam,

Subramanian Shivakumar

et al. 2024

ChemistrySelect

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“…The two fractions chloroform fractions T. domingensis (CFTD) and n- butanol of T. domingensis (BFTD) fractions were obtained. These fractions were also evaporated with the rotary evaporator at 40°C, air-dried, and stored for further analysis [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Chemical Composition and Biological Evaluation of Typha domingensis Pers. to Ameliorate Health Pathologies: In Vitro and In Silico Approaches

Dilshad

Khan

Saeed

et al. 2022

BioMed Research International

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Human diseases are becoming more prevalent, necessitating the development of modalities to overcome the challenges of treating various disorders. In the current research, we analyzed the biomedicinal role of Typha domingensis which is an important medicinal plant. The species is traditionally used in the treatment of neurological disorders and skin malignancies. The chloroform (CFTD) and n-butanol fractions of T. domingensis (BFTD) were subjected to chemical profiling through the determination of total polyphenolic contents and GC-MS analysis. The oral toxicity test was applied to investigate the toxicity of the extracts. Antioxidant capacity was analyzed by four in vitro methods: DPPH, ABTS, FRAP, and CUPRAC. The pharmacological potential was evaluated through clinically significant enzyme inhibition assays, thrombolytic, and antimicrobial activities. In silico molecular docking approach was applied to confirm the role of T. domingensis against the enzymes. The polyphenolic quantification revealed that the BFTD was comparatively rich in total phenolic and flavonoid contents (97.14 milligrams gallic acid equivalent (mg GAE/g) and 362.5 milligrams quercetin equivalent per gram of dry extract (mg QE/g DE), respectively), as compared to the CFTD. The GC-MS analysis of the CFTD and BFTD resulted in the tentative identification of 67 and 29 compounds, respectively, with the major components of fatty acids and essential oil. The oral toxicity test revealed the safety and biocompatibility of CFTD and BFTD. Both the fractions showed promising antioxidant activity. Tyrosinase was found as the major enzyme inhibited by BFTD (78.67%) and CFTD (68.09%), whereas the standard kojic acid showed 85.58% inhibition. The inhibition results of acetylcholinesterase and butyrylcholinesterase by BFTD (71.65 and 60.79%, respectively) are higher than CFTD. Both the fractions were found active against various strains of bacteria. Furthermore, the molecular docking studies of the compounds showed a good docking score against all the docked enzymes among which deoxycaesaldekarin C was found with the highest binding affinities in comparison to the standard. The current study suggests that T. domingensis is nontoxic and can be a potential source of phytoconstituents with promising pharmacological potential.

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“…Herein, the lesser zone of inhibition may be due to the high resistance of Gram-negative bacteria due to the cell membrane made of lipopolysaccharide, which is impermeable to the non-polar (lipophilic) metabolites. Peptidoglycan is the external layer in Gram-positive strains of bacteria, which is permeable to lipophilic metabolites [125]. These findings were required to compare the antibacterial activity of the plant of study with its bioactive phytochemicals and strong antioxidants potential; however, more investigation and purification of phenolic components may lead to the development of natural antibacterial agents for functional foods, nutraceuticals, and pharmaceuticals, to improve the shelf life and to extend health benefits in those systems.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural Products Development

et al. 2022

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The purpose of this study was to find the biological propensities of the vegetable plant Pleurospermum candollei by investigating its phytochemical profile and biological activities. Phytochemical analysis was done by spectroscopic methods to investigate the amount of total polyphenols, and biological evaluation was done by the different antioxidant, enzyme inhibitory (tyrosinase, α-amylase, and α-glucosidase), thrombolytic, and antibacterial activities. The highest amount of total phenolic and flavonoid contents was observed in methanolic extract (240.69 ± 2.94 mg GAE/g and 167.59 ± 3.47 mg QE/g); the fractions showed comparatively less quantity (57.02 ± 1.31 to 144.02 ± 2.11 mg GAE/g, and 48.21 ± 0.75 to 96.58 ± 2.30 mg QE/g). The effect of these bioactive contents was also related to biological activities. GCMS analysis led to the identification of bioactive compounds with different biological effects from methanolic extract (antioxidant; 55.07%, antimicrobial; 56.41%), while the identified compounds from the n-hexane fraction with antioxidant properties constituted 67.86%, and those with antimicrobial effects constituted 82.95%; however, the synergetic effect of polyphenols may also have contributed to the highest value of biological activities of methanolic extract. Molecular docking was also performed to understand the relationship of identified secondary metabolites with enzyme-inhibitory activities. The thrombolytic activity was also significant (40.18 ± 1.80 to 57.15 ± 1.10 % clot lysis) in comparison with streptokinase (78.5 ± 1.53 to 82.34 ± 1.25% clot lysis). Methanolic extract also showed good activity against Gram-positive strains of bacteria, and the highest activity was observed against Bacillus subtilis. The findings of this study will improve our knowledge of phytochemistry, and biological activities of P. candollei, which seems to be a ray of hope to design formulations of natural products for the improvement of health and prevention of chronic diseases; however, further research may address the development of novel drugs for use in pharmaceuticals.

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Phytochemical, pharmacological, and In-silico molecular docking studies of Strobilanthes glutinosus Nees: An unexplored source of bioactive compounds

Cited by 16 publications

References 23 publications

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Chemical Composition and Biological Evaluation of Typha domingensis Pers. to Ameliorate Health Pathologies: In Vitro and In Silico Approaches

Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural Products Development

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