Phytochemical investigation and evaluation of in vitro anti-inflammatory activity of Euphorbia hirta ethanol leaf and root extracts: A comparative study

Anti-cholinesterase, anti-inflammatory and antioxidant properties of Combretum micranthum G. Don: Potential implications in neurodegenerative disease

“…Numerous anti-inflammatory drugs deter thermally prompted protein denaturation ( Anokwah et al, 2022 ). Protein denaturation is the principal cause of inflammatory and arthritic disorders that proceed to auto-antigens generation, which can initiate the auto-immune reaction that can converge onto the rheumatic arthritis ( Das et al, 2022 ). Auto-antigens formation due to thermally induced protein denaturation causes the alterations in disulfide, hydrogen and electrostatic hydrophobic bonding ( Anokwah et al, 2022 ).…”

“…The anti-inflammatory mechanism of action of CM extract via prevention of proteins denaturation could be explained based on previous findings. Indeed, Protein denaturation occurs during tissue injury or inflammatory process ( Das et al, 2022 ). Numerous anti-inflammatory drugs deter thermally prompted protein denaturation ( Anokwah et al, 2022 ).…”

Ethnobotanical Review of Selected Medicinal Plants in Guam for the Treatment of Urinary Tract Ailments and Their Pharmacological Properties

“…Subramani et al [19] reported antibacterial and antifungal activity against common oral pathogens such as S. mutans (ZOI = 11 ± 0.54 mm), Lactobacillus acidophilus (ZOI = 10 ± 0.04 mm), E. coli (ZOI = 13 ± 0.05 mm), and C. albicans (ZOI = 14 ± 0.59 mm) at a concentration of 5 mg/mL. Ethanol leaf extract exhibited significant anti-inflammatory activity compared to roots by inhibiting albumin denaturation, proteinase, and lipoxygenase activity, with 87.51% and 51.2%, followed by 97.30% and 54.21%, followed by 94.43% and 48.21%, respectively, at a concentration of 100 lg/mL [23]. Sulaiman et al [24] studied major groups of secondary metabolites of E. hirta such as phenolics, flavonoids, and sterols, which showed significant dose-dependent anticancer activity against Ehrlich-ascites-carcinoma-induced periotoneal ascites in mice.…”

“…Leaves: antimicrobial [19][20][21][22]; anti-inflammatory [23]; anticancer [24]; antioxidant and antifungal [25].…”

“…hirta contains various secondary metabolites which contribute to its potential therapeutic properties. Ethanol extracts of E. hirta leaves and roots contain a diverse range of bioactive compounds, including alkaloids, glycosides, flavonoids, tannins, and phenolics [23]. Aqueous, ethanol, and methanol extracts of E. hirta leaves contain tannins, saponins, steroids, terpenoids, flavonoids, triterpenoids, polyphenol, glycoside, anthocyanins, and coumarins [18].…”