Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent

Rajakrishnan, R.; Lekshmi, R.; Benil, P.B.; Thomas, J.; Alfarhan, Ahmed; Rakesh, V.; Khalaf, S.

doi:10.1016/j.sjbs.2017.01.001

Cited by 47 publications

(36 citation statements)

References 20 publications

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“…The level of creatinine, urea, uric acid and blood urea nitrogen was higher in the cisplatin-treated group whereas the biochemical marker are lowered by the ethyl acetate crude extract of Momordica dioica and ethyl acetate extract of Caeselpinia bonduc in comparision to the control group, which shows better nephro-protectivity in compare with the results shown by ethanol extract of S. hypericifolia against paracetamol induced nephrotoxicity [2]. The hydro alcoholic extract of P. zeylanica showed better prevention against cisplatin-induced renal damage by significantly reducing the elevated levels of urea, creatinine and uric acid in serum [5]. However serum SGOT, SGPT and alkaline phosphatise level of Momordica dioica and Caeselpinia bonduc treated samples demonstrated higher protectivity against cisplatininduced nephrotoxicity than that of cisplatin and was comparable to the standard drug silymarin.…”

Section: Discussionmentioning

confidence: 88%

“…In terms of medication, the drug, cisplatin, which is widely used in a variety of treatment process against several forms of cancer, is also a major cause of kidney malfunctioning. Cisplatin is used in the treatment of solid tumors of the head, neck, ovary, breasts, lung and testicular cancer [5]. However, the major limitation of cisplatin is its ototoxic and nephrotoxic activity which limits its effectiveness.…”

Section: Introductionmentioning

confidence: 99%

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Nephroprotective Activity of the Ethnomedicinal Plants Caesalpinia Bonduc and Momordica Dioica From Ne India Against Cisplatin Induced Chemotherapeutic Toxicity

Talukdar

Kalita

Gohain

et al. 2018

Int J Pharm Pharm Sci

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Objective: Cisplatin a potent anticancer drug is used for treatment against different forms of cancer. However a major limitation of cisplatin is its nephrotoxicity and severe side effects. The main objective of the present study was to investigate the nephroprotective activity of the medicinal plants Caesalpinia bonduc and Momordica dioica against cisplatin-induced nephrotoxicity. Methods:In the present study wistar rat models were intraperitoneally injected with cisplatin for eight consecutive days Plant extracts of different compositions were administered for eight days after injection of cisplatin. The polyphenolic content of the crude extracts was investigated using the Folin Ciocalteau method while the flavonoid estimation was carried out using the aluminium chloride method. The antioxidant activities of the extracts were assayed using the DPPH radical scavenging method. Plant extracts were tested for their nephroprotective ability using modified Berthelot method, uricase method, alkaline picrate method. Results:In the present study it was found that the level of creatinine, urea, uric acid and blood urea nitrogen was lowered by the crude hexane extract of Momordica dioica and ethyl acetate extract of Caesalpinia bonduc as compared to the control group. The total phenolic content and the total flavonoid content was found to be highest in the hexane extract of Momordica dioica with 110.51±1.0 μg/GAE and 1.92±0.15 μg/QE. The methanol extract of Caesalpinia bonduc was found to be the highest in inhibition of the DPPH free radicals with nearly 80% inhibition. Conclusion:The present study revealed the nephroprotective ability of the hexane extract of Momordica dioica and ethyl acetate extract Caeselpinia bonduc. The extracts were also found to have higher antioxidant activity and therefore their nephroprotective activity might be due to attenuation of oxidative stress.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Nephroprotective Activity of the Ethnomedicinal Plants Caesalpinia Bonduc and Momordica Dioica From Ne India Against Cisplatin Induced Chemotherapeutic Toxicity

Talukdar

Kalita

Gohain

et al. 2018

Int J Pharm Pharm Sci

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“…The highest peak (92·25% area) is identified as 1,4‐naphthalenedione, which matches with the phytochemical plumbagin reported to be present in P. zeylanica (Rajakrishnan et al . ). This observation suggests plumbagin, a naphthoquinone agent is the active principle driving the anti‐bacterial activity.…”

Section: Resultsmentioning

confidence: 97%

“…The ACN crude extract of P. zeylanica was subjected to GCMS by following a previously described procedure (Rajakrishnan et al . ) to identify the constituents of the crude extract.…”

Section: Methodsmentioning

confidence: 99%

In vitroantibacterial activity of plumbagin isolated fromPlumbago zeylanicaL. against methicillin‐resistantStaphylococcus aureus

Periasamy

Iswarya

Pavithra

et al. 2019

Lett Appl Microbiol

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Plumbagin (5‐hydroxy‐2‐methyl‐1,4‐napthoquinone) is a bicyclic naphthoquinone, found in three major plant families viz. Plumbaginaceae, Ebenceae and Droseraceae. The phytochemical is reported to exhibit various pharmacological properties. In this study, plumbagin isolated from Plumbago zeylanica L. was investigated for its in vitro activity against methicillin‐resistant Staphylococcus aureus (MRSA). Against 100 MRSA isolates that included multi‐drug‐resistant phenotypes, plumbagin showed consistent activity with a narrow minimum inhibitory concentration (MIC) range of 4–8 μg ml−1. The time‐kill study revealed 99% kill of a reference MRSA strain, 8 h after exposure to plumbagin. In the combination MIC study using the reference MRSA strain, plumbagin showed synergistic effect with ciprofloxacin and piperacillin while additive or indifference effect with other commonly used antibiotics. The transmission electron micrograph of the reference MRSA strain treated with plumbagin confirmed cell wall and cytoplasmic changes. Our results demonstrated potent anti‐MRSA activity of plumbagin which was not impacted by multi‐drug resistance. This is a first ever study that evaluated in vitro anti‐MRSA activity of plumbagin employing large number of MRSA isolates. The findings of this study support the need for the further investigation on this phytochemical agent for therapeutic application. Significance and Impact of the Study This study revealed phytochemical plumbagin's potent and consistent in vitro antibacterial activity against clinically problematic methicillin‐resistant Staphylococcus aureus (MRSA) including multi‐drug‐resistant (MDR) phenotypes. The study results support further research to assess the clinical scope of plumbagin.

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“…Creatinine and urea levels are used as biochemical markers of kidney injuries, thus elevated levels of these markers may indicate kidney dysfunction, though the test for creatinine is a better indicator than urea [20]. Creatinine is a non-protein nitrogenous substance formed from creatine and phosphocreatine during muscle metabolism but excreted by glomerular filtration.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of aqueous extract of Lophira lanceolata leaf against cisplatin-induced hepatorenal injuries and dyslipidemia in Wistar rats

2020

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Background: Hepatorenal injuries and dyslipidemia are common global health challenges but medicinal plant extracts may have potential to prevent them. Thus, this study evaluated the protective effect of aqueous extract of Lophira lanceolata leaf (LLE) against cisplatin-induced hepatorenal injuries and dyslipidemia in albino Wistar rats. Methods: Thirty rats were randomly divided into 6 groups of 5 rats each. Group I rats received distilled water and served as control, group II rats were given 5 mg/kg cisplatin (CIS) intraperitoneally, groups III and IV rats were treated with 200 and 400 mg/kg LLE respectively for 26 days by oral gavages while groups V and VI rats were treated with 200 and 400 mg/kg LLE respectively, followed by CIS on the 21st day as in group II. About 24 h after treatment, blood was collected from the rats; then serum was separated and used for estimations of biochemical parameters. The kidney and liver of rats were removed, rinsed in normal saline, stored in 10% formalin and used for histological analyses. Results: The biomarkers of hepatic (Aminotransferases, Alkaline phosphatase and Bilirubin) and renal (urea and creatinine) injuries, and dyslipidemia (Total cholesterol, triglycerides and LDL-cholesterol) significantly (p < 0.05) increased in the rats exclusively exposed to cisplatin when compared with normal control. However, treatment of cisplatin-exposed rats with 200 and 400 mg/kg LLE significantly (p < 0.05) reduced the levels of these biomarkers of hepatorenal injuries and dyslipidemia when compared with cisplatin control. Photomicrographs showed pathological signs in the liver and kidney of rats exclusively exposed to cisplatin, but there was moderate protection of these tissues in the rats treated with LLE and cisplatin. Conclusion: The current findings have shown that Lophira lanceolata leaf extract may provide moderate protection against cisplatin-induced hepatorenal injuries and dyslipidemia in albino Wistar rats.

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Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent

Cited by 47 publications

References 20 publications

Nephroprotective Activity of the Ethnomedicinal Plants Caesalpinia Bonduc and Momordica Dioica From Ne India Against Cisplatin Induced Chemotherapeutic Toxicity

Nephroprotective Activity of the Ethnomedicinal Plants Caesalpinia Bonduc and Momordica Dioica From Ne India Against Cisplatin Induced Chemotherapeutic Toxicity

In vitroantibacterial activity of plumbagin isolated fromPlumbago zeylanicaL. against methicillin‐resistantStaphylococcus aureus

Protective effect of aqueous extract of Lophira lanceolata leaf against cisplatin-induced hepatorenal injuries and dyslipidemia in Wistar rats

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