Phytochemical contents, antioxidant and antibacterial activity of the ethanolic extracts of Centella asiatica(L.) Urb.leaf and stem

Polash, Shakil Ahmed; Saha, Tanushree; Hossain, Shahdat; Sarker, Satya Ranjan

doi:10.3329/jujbs.v6i1.33731

Cited by 14 publications

(12 citation statements)

References 12 publications

(12 reference statements)

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“…T. connaroid was reported to contain norterpenoids (Wang et al, 2013), and reports related to phenolic and flavonoid estimation are not available. The aqueous and ethanolic extracts of C. Asiatica have been investigated for total phenolic, flavonoid, and antioxidant activity (Pittella et al, 2009;Polash et al, 2017). It was reported that only 4.58±0.44 mg/g polyphenols were found in 37% aqueous ethanol extract of C. Asiatica (Gunathilak et al, 2019) collected from Sri Lanka which was very low than our findings (100.71 ±2.37 mg GAE/g).…”

Section: Total Phenolic and Flavonoid Content In Different Extractscontrasting

confidence: 65%

Phytochemical Evaluation of Some Medicinal Plants of Puthan District of Nepal

Giri

Rajbhandari

2020

Nepal Journal of Science and Technology

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Different parts of eleven medicinal plants used in the traditional medicine in Puthan district were collected. Three different extracts, methanol, 50% aqueous methanoland 70% aqueous acetone extractswere prepared for each plant material. The methanol extractswere screened for the presence of different classes of phytochemicals. Total phenolic andflavonoid content, as well as DPPH freeradical scavenging activity, were evaluated. All the investigated extracts contain a high amount of phenolics and flavonoids.The highest amount of phenolicsand flavonoids were detected in the methanolextract of bark of Bauhinia variegate(355.35+3.69 mg GAE/g and 209.23 ±1.25 mg QE/g extract). Among the eight tested extracts, the highest radical scavenging activity was shown by methanol extract of bark of B. variegate (IC50 3.68 μg/ml). The extract having the highest phenolic and flavonoid content showed the lowest IC50 demonstrating the positive correlation between radical scavenging activity and total phenolic and flavonoid content.

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Section: Total Phenolic and Flavonoid Content In Different Extractscontrasting

confidence: 65%

Phytochemical Evaluation of Some Medicinal Plants of Puthan District of Nepal

Giri

Rajbhandari

2020

Nepal Journal of Science and Technology

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“…Crude extracts and their stock solutions preparation were prepared according to our previously established protocol [21] [22] [23]. About 5 g of powdered materials of both seed and flesh were taken in clean conical flasks and mixed with 100 ml of the respective solvents.…”

Section: Preparation Of Crude Extract and Fractionationmentioning

confidence: 99%

Investigation of the Phytoconstituents and Antioxidant Activity of Diospyros malabarica Fruit Extracts

Shubhra¹,

Polash²,

Saha³

et al. 2019

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“…Crude extracts and their stock solutions were prepared according to our previously established protocol [16][17][18][19][20][21]. Briefly, 5 g of powdered materials of both seed and flesh were taken in clean conical flasks and soaked in 100 ml of the respective solvents.…”

Section: Preparation Of Crude Extract and Fractionationmentioning

confidence: 99%

Investigation of the Antimicrobial Activity and in Vivo Cytotoxicity of Diospyros malabarica (Desr.) Kostel. Fruit Extracts

Shubhra¹,

Polash²,

Hossain³

et al. 2021

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Mankind is facing an unprecedented threat of existence due to the antibiotic resistance developed by bacteria. The unripe fruits of Diospyros malabarica (Desr.) Kostel. (family: Ebenaceae) can be considered as one of the natural sources to tackle this issue. The present study is designed to assess the antimicrobial activity of D. malabarica seed and flesh extracts. Herein, D. malabarica extracts were prepared using polar solvents (i.e., water and 70% ethanol) and their antimicrobial activity as well as in vivo toxicity was investigated. Their antibacterial activity was investigated against gram positive (Bacillus subtilis) and gram negative (Escherichia coli DH5α, and Salmonella typhi) bacteria at different time points. All the extracts showed the highest antibacterial activity after 2 hours of incubation. The aqueous seed extract showed the maximum zone of inhibition (i.e., ~13 mm) against Bacillus subtilis with a minimum inhibitory concentration (MIC) value of 2 µg/µl. The antibacterial propensity was also confirmed through trypan blue dye exclusion assay, Cell-Tox TM Green assay, and lipid peroxidation (LPO) assay. On the other hand, the ethanolic seed extract demonstrated higher antifungal activity through inhibition of mycelial growth. All the extracts showed excellent hemocompatibility against both human and rat red blood cells (RBCs). They also did not show any toxicity to rat liver and kidneys. Taken together, this study demonstrates that the aqueous and ethanolic extracts of D. malabarica seed and flesh could be an effective source of natural antimicrobial agents with no cytotoxic activity.

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Phytochemical contents, antioxidant and antibacterial activity of the ethanolic extracts of Centella asiatica(L.) Urb.leaf and stem

Abstract: not availableJahangirnagar University J. Biol. Sci. 6(1): 51-57, 2017 (June)

Cited by 14 publications

References 12 publications

Phytochemical Evaluation of Some Medicinal Plants of Puthan District of Nepal

Phytochemical Evaluation of Some Medicinal Plants of Puthan District of Nepal

Investigation of the Phytoconstituents and Antioxidant Activity of <i>Diospyros malabarica</i> Fruit Extracts

Investigation of the Antimicrobial Activity and <i>in Vivo </i> Cytotoxicity of <i>Diospyros malabarica </i> (Desr.) Kostel. Fruit Extracts

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Phytochemical contents, antioxidant and antibacterial activity of the ethanolic extracts of Centella asiatica(L.) Urb.leaf and stem

Abstract: not availableJahangirnagar University J. Biol. Sci. 6(1): 51-57, 2017 (June)

Cited by 14 publications

References 12 publications

Phytochemical Evaluation of Some Medicinal Plants of Puthan District of Nepal

Phytochemical Evaluation of Some Medicinal Plants of Puthan District of Nepal

Investigation of the Phytoconstituents and Antioxidant Activity of &lt;i&gt;Diospyros malabarica&lt;/i&gt; Fruit Extracts

Investigation of the Antimicrobial Activity and &lt;i&gt;in Vivo &lt;/i&gt; Cytotoxicity of &lt;i&gt;Diospyros malabarica &lt;/i&gt; (Desr.) Kostel. Fruit Extracts

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Investigation of the Phytoconstituents and Antioxidant Activity of <i>Diospyros malabarica</i> Fruit Extracts

Investigation of the Antimicrobial Activity and <i>in Vivo </i> Cytotoxicity of <i>Diospyros malabarica </i> (Desr.) Kostel. Fruit Extracts