Phytochemical Constituents and Anticoagulation Property of Marine Algae Gelidium crinale, Sargassum hornschuchii and Ulva linza

El-Din, Soad M. Mohy; Alagawany, N. I.

doi:10.1007/s41208-019-00142-6

Cited by 13 publications

(8 citation statements)

References 35 publications

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“…Marine algae are abundant and various species have been recently investigated as potential cosmeceutical and nutraceutical agents, and for therapeutic applications [46]. Algae are recognized as a source of important bioactive ingredients, such as antioxidants, proteins, vitamins, minerals, soluble dietary fibers, polyunsaturated fatty acids, polysaccharides, and photosynthetic pigments [19,31,[47][48][49][50]. Moreover, epidemiological studies showed that there was an association between algae consumption and a lower incidence of neurodegenerative diseases [16,19,46,47].…”

Section: Discussionmentioning

confidence: 99%

Enteromorpha prolifera Extract Improves Memory in Scopolamine-Treated Mice via Downregulating Amyloid-β Expression and Upregulating BDNF/TrkB Pathway

Baek

Kim

et al. 2020

Antioxidants

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Enteromorpha prolifera, a green alga, has long been used in food diets as well as traditional remedies in East Asia. Our preliminary study demonstrated that an ethyl acetate extract of Enteromorpha prolifera (EAEP) exhibited the strongest antioxidant activity compared to ethanol or water extracts. Nonetheless, there has been no report on the effect of EAEP on memory impairment due to oxidative damage. This study investigated whether EAEP could attenuate memory deficits in an oxidative stress-induced mouse model. EAEP was orally administered (50 or 100 mg/kg body weight (b.w.)) to mice and then scopolamine was administered. The oral administration of EAEP at 100 mg/kg b.w. significantly restored memory impairments induced by scopolamine, as evaluated by the Morris water maze test, and the passive avoidance test. Further, EAEP upregulated the protein expression of BDNF, p-CREB, p-TrkB, and p-Akt. Moreover, EAEP downregulated the expression of amyloid-β, tau, and APP. The regulation of cholinergic marker enzyme activities and the protection of neuronal cells from oxidative stress-induced cell death in the brain of mice via the downregulation of amyloid-β and the upregulation of the BDNF/TrkB pathway by EAEP suggest its potential as a pharmaceutical candidate to prevent neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Enteromorpha prolifera Extract Improves Memory in Scopolamine-Treated Mice via Downregulating Amyloid-β Expression and Upregulating BDNF/TrkB Pathway

Baek

Kim

et al. 2020

Antioxidants

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“…1-Hexadecanol, also called cetyl alcohol or palmityl alcohol, is a fatty acid that has a moderate retention time and is widely used in the cosmetic industry as a non-gelling thickening agent (Ribeiro et al, 2004). Recently, hexadecane was identified in seaweeds by Mohy El-Din and Alagawany (2019). In this study, 1,2-Benzenediol and were detected with the lowest retention times at 13.73 and 13.25 minutes, respectively, in the ME of S. tenerrimum.…”

Section: Gc-ms Analysismentioning

confidence: 50%

Spectral analysis and Antibacterial activity of the bioactive principles of Sargassum tenerrimum J. Agardh collected from the Red sea, Jazan, Kingdom of Saudi Arabia

Albratty

Alhazmi

Meraya³

et al. 2023

Braz. J. Biol.

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Seaweeds are a major marine resource that can be explored to develop novel pharmaceutical molecules. The present study showed the presence of unique bioactive components in the petroleum ether extract (PEE) and methanolic extract (ME) of Sargassum tenerrimum. The gas chromatography-mass spectrometry analysis suggested that the PEE of S. tenerrimum contained antibacterial biomolecules: hexadecanoic acid, methyl ester, 17-pentatriacontene, dasycarpidan-1-methanol, and acetate (ester). However, the ME of S. tenerrimum exhibited better antibacterial effect than the PEE due to the presence of the bioactive compounds 1,2-benzenedicarboxylic acid, diisooctyl ester, tetratetracontane, 1-docosene, 1,2-benzenediol, and benzoic acid. Thus, promising antibacterial molecules can be isolated from S. tenerrimum for better therapeutic use.

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“…DIOP was found in methanolic extracts of red algae Gelidium crinale, brown algae Sargassum hornschuchii, and green algae Ulva linza, which exhibited a high antioxidant effect [30].…”

Section: Principal Paes Studies In Algaementioning

confidence: 99%

“…Although some macroalgae, such as Ulva sp., Sargassum sp., Gracialaria sp., or Pterocladia sp., have the remarkable capacity to adsorb lipophilic pollutants [13,30] and endocrine active substances [15], including phthalates [8,48], and can potentially be used for bioremediation approaches, studies have shown that micro-and macroalgae produce phthalates via biosynthetic pathways [33,34,44] probably through the shikimic acid pathway [3,49].…”

Section: Biosynthesismentioning

confidence: 99%

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The Origin of Phthalates in Algae: Biosynthesis and Environmental Bioaccumulation

Pace,

Vaglica,

Maccotta

et al. 2024

Environments

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Phthalic acid esters (PAEs) are a class of ubiquitous and dangerous lipophilic chemicals widely used as additives in various products to improve their physical and chemical properties. Although they have been banned in many countries, their persistence in all environmental compartments is of particular concern. The aquatic environment is especially affected by these compounds because it is strongly influenced both by contamination of anthropic origin and natural contaminants including those produced biosynthetically by some organisms such as algae. In this context, algal organisms can be a source and remedy for phthalate pollution. Both the increase and decrease in uptake and production depend on the physicochemical characteristics of the environment. The dynamics of the natural processes are aimed at achieving an optimal environmental state for their competitiveness and balance of the cellular homeostasis. This review summarizes the studies dealing with biosynthesis and bioaccumulation of phthalates in algae and investigates the source of their origin by suggesting strategies to identify the process leading to their presence.

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Phytochemical Constituents and Anticoagulation Property of Marine Algae Gelidium crinale, Sargassum hornschuchii and Ulva linza

Cited by 13 publications

References 35 publications

Enteromorpha prolifera Extract Improves Memory in Scopolamine-Treated Mice via Downregulating Amyloid-β Expression and Upregulating BDNF/TrkB Pathway

Enteromorpha prolifera Extract Improves Memory in Scopolamine-Treated Mice via Downregulating Amyloid-β Expression and Upregulating BDNF/TrkB Pathway

Spectral analysis and Antibacterial activity of the bioactive principles of Sargassum tenerrimum J. Agardh collected from the Red sea, Jazan, Kingdom of Saudi Arabia

The Origin of Phthalates in Algae: Biosynthesis and Environmental Bioaccumulation

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