PHYTOCHEMICAL CONSTITUENT OF Picria fel-terrae Lour. ETHANOL EXTRACT AND ITS TERATOGENIC EFFECT

Abstract

The objective of this study is to determine phytochemical constituent in the ethanol extract of Picria fel-terrae leaves as well as to examine the teratogenic effect toward the fetus. There are five groups consists of pregnant rats. Group 1 was the healthy control; groups 2, 3, 4 received extract at the dose of 125, 500 and 1000 mg/kg respectively, group 5 was positive control group (received gabapentin 50 mg/kg). The treatment was performed during the organogenesis period. On the 19 th day, maternal laparotomy was carried out, and the fetus was removed. Observations were including reproduction and uterus performance as well as external malformation.Phytochemical screening revealed that the extract consists of flavonoids, tannins, glycosides, saponins and steroids/triterpenoids. Administration extract at the dose of 125, 500, 1000 mg/kg revealed significant effect to the weight loss, fetal body length, number of dead fetuses, resorption and haemorrhages compared to healthy control (p<0.05). The uterus abnormality was found in the group of extract dose of 500 mg/kg as well as 1000 mg/kg. All groups undergo external malformations. The research concluded that all doses of the ethanol extract of P. fel-terrae leaves had the teratogenic effect on the fetus.

Wild edible vegetables of ethnic communities of Mizoram (Northeast India): an ethnobotanical study in thrust of marketing potential

“…These results may further indicate that this plant species has a strong healing ability in the traditional medicinal practices of the region. Investigations on the bioactive compounds such as flavonoids, tannins, glycosides, saponin, and steroids, which might be responsible for its potential curing agents for diabetes, inflammation, diuretic, hepatoprotective, cancer, and asthma, have also been reported [ 71 , 72 ]. High-fidelity medicinal plants showed the informants' preference for the given species to treat disease [ 60 ].…”