Phytochemical Composition, Antioxidant and Antimicrobial Activity of the Balkan Endemic Micromeria frivaldszkyana (Degen) Velen. (Lamiaceae)

Mladenova, Tsvetelina; Stoyanov, Plamen; Denev, Petko; Dimitrova, Stela; M, Katsarova; Teneva, Desislava; Todorov, Krasimir; Bivolarska, Anelia

doi:10.3390/plants10040710

Cited by 7 publications

(9 citation statements)

References 35 publications

(26 reference statements)

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“…Due to the broad spectrum of the biological activities (e.g., antimicrobial, antifungal, antioxidant, anti-inflammatory, anticancer, biocidal, etc.) of their secondary metabolites, Lamiaceae plants are used by local people based on their inherited empirical skills, or as a result of acquisition and exchange of traditional and/or modern knowledge [8][9][10][11][12]. Numerous ethnobotanical studies reported on the various past and current utilizations of different Lamiaceae taxa around the world and in Europe [4,[13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Lamiaceae Plants in Bulgarian Rural Livelihoods—Diversity, Utilization, and Traditional Knowledge

et al. 2022

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Lamiaceae comprises widely distributed medicinal and aromatic plants, many of which are traditionally used in European countries. The current study aimed to document Lamiaceae taxa used in rural Bulgaria (Southeast Europe) and to explore the related local knowledge and cultural practices that influence their utilization for various purposes. Field work included inventory of Lamiaceae diversity in home gardens and semi-structured interviews focused on the cultivation, collection, and utilization practices common among elderly inhabitants of 34 settlements in rural Bulgaria. We report the utilization of 27 Lamiaceae taxa, 9 of which were collected from the wild. Traditional and contemporary ways of utilizing Lamiaceae taxa as culinary and medicinal plants, in herbal teas, as repellents, ritual plants, etc., are presented. Recent knowledge on medicinal properties contributed to the introduction of new taxa in gardens (wild and cultivated), while traditional culinary practices were found to sustain the diversity of local forms (landraces).

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Section: Introductionmentioning

confidence: 99%

Lamiaceae Plants in Bulgarian Rural Livelihoods—Diversity, Utilization, and Traditional Knowledge

et al. 2022

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“…Currently, the only data available in the scientific literature regarding the biological effects of M. frivaldszkyana extracts are reports on the antimicrobial and antioxidant activities of the plant, accompanied with some information about its phytochemical metabolites [2,7]. Similar effects are reported for plants of the genus Stachys, which also belong to the Lamiaceae family [14].…”

Section: Introductionmentioning

confidence: 89%

“…However, the general interest is focused on plants that are well known in traditional phytomedicine like Rosmarinus officinalis, Lavandula officinalis, Curcuma longa, Berberis vulgaris, etc. Many endemic plants remain out of the scope of scientific studies, and information about their phytochemical composition and biological effects is scarce [2].…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Composition of Methanolic Extract of the Balkan Endemic Species Micromeria frivaldszkyana (Degen) Velen and Its Anti-Inflammatory Effect on Male Wistar Rats

Stavrakeva,

Metodieva,

Benina

et al. 2024

IJMS

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Extracts from medicinal plants are widely used in the treatment and prevention of different diseases. Micromeria frivaldszkyana is a Balkan endemic species with reported antioxidant and antimicrobial characteristics; however, its phytochemical composition is not well defined. Here, we examined the metabolome of M. frivaldszkyana by chromatography–mass spectrometry (GC-MS), ultra-performance liquid chromatography–mass spectrometry (UPLC-MS-MS), and inductively coupled plasma mass spectrometry (ICP-MS). Amino acids, organic acids, sugars, and sugar alcohols were the primary metabolites with the highest levels in the plant extract. Detailed analysis of the sugar content identified high levels of sucrose, glucose, mannose, and fructose. Lipids are primary plant metabolites, and the analysis revealed triacylglycerols as the most abundant lipid group. Potassium (K), magnesium (Mg), zinc (Zn), and calcium (Ca) were the elements with the highest content. The results showed linarin, 3-caffeoil-quinic acid, and rosmarinic acid, as well as a number of polyphenols, as the most abundant secondary metabolites. Among the flavonoids and polyphenols with a high presence were eupatorin, kaempferol, and apigenin—compounds widely known for their bioactive properties. Further, the acute toxicity and potential anti-inflammatory activity of the methanolic extract were evaluated in Wistar rats. No toxic effects were registered after a single oral application of the extract in doses of between 200 and 5000 mg/kg bw. A fourteen-day pre-treatment with methanolic extract of M. frivaldszkyana in doses of 250, 400, and 500 mg/kg bw induced anti-inflammatory activity in the 1st, 2nd, and 3rd hours after carrageenan injection in a model of rat paw edema. This effect was also present in the 4th hour only in the group treated with a dose of 500 mg/kg. In conclusion, M. frivaldszkyana extract is particularly rich in linarin, rosmarinic acid, and flavonoids (eupatorin, kaempferol, and apigenin). Its methanolic extract induced no toxicity in male Wistar rats after oral application in doses of up to 5000 mg/kg bw. Additionally, treatment with the methanolic extract for 14 days revealed anti-inflammatory potential in a model of rat paw edema on the 1st, 2nd, and 3rd hours after the carrageenan injection. These results show the anti-inflammatory potential of the plant, which might be considered for further exploration and eventual application as a phytotherapeutic agent.

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“…The presence of phenolic acids and flavonoids were determined using HPLC method described by Mladenova et al [21].…”

Section: Hplc Analysesmentioning

confidence: 99%

Endophytic microflora from Ficus carica L. leaves – isolation, characterization and potential for application

et al. 2022

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Fig leaves (Ficus carica L.) are widely used in traditional medicine as a remedy or for prevention of many health problems (lowering blood sugar and triglyceride levels, cardiovascular diseases, etc.). The aim of the research was isolation of endophytic microflora, its characterization and proving its potential for future application. Two endophytic bacteria Streptococcus sp. Fcl1 and Kocuria rhizophila Fcl20 were isolated from the fig leaves and characterized. Using HPLC method was also determined the polyphenolic profile of aqueous-alcoholic extract (70% (v/v) ethanol) and microwave-assisted aqueous extract of fig leaves, for the purpose of phytochemical characterization of the plant, for subsequent study of the endophyte-plant relationship. The main found phenolic acids and flavonoids in extracts were: (+)-catechin, vanillic acid, syringic acid, (-)-epicatechin, ferulic acid, salicylic acid, rosmarinic acid, rutin.

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Phytochemical Composition, Antioxidant and Antimicrobial Activity of the Balkan Endemic Micromeria frivaldszkyana (Degen) Velen. (Lamiaceae)

Cited by 7 publications

References 35 publications

Lamiaceae Plants in Bulgarian Rural Livelihoods—Diversity, Utilization, and Traditional Knowledge

Lamiaceae Plants in Bulgarian Rural Livelihoods—Diversity, Utilization, and Traditional Knowledge

Metabolic Composition of Methanolic Extract of the Balkan Endemic Species Micromeria frivaldszkyana (Degen) Velen and Its Anti-Inflammatory Effect on Male Wistar Rats

Endophytic microflora from Ficus carica L. leaves – isolation, characterization and potential for application

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