Phytochemical characters of<i>teucrium marum</i>from Sardinia: an endemic plant

Bianco, Armandodoriano; Ramunno, Alessia; Am, Serrilli; M, Lo Castro; Ballero, Mauro; Serafini, Mauro

doi:10.1080/14786410310001630564

Cited by 11 publications

(10 citation statements)

References 11 publications

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“…Table 5 summarizes some important bioactive molecules isolated from the Teucrium species, mainly T. polium , using various identification techniques and different extraction procedures [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…Different techniques were used to identify the bioactive compounds in T. polium aerial parts extracts, using different solvents (water, methanol, 65.5% menthol–water, dichloromethane/methanol, acetone, ethanol 70%, and ethanol 95%) from different regions around the world [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. A literature review of the phytochemical compounds isolated from T. polium aerial parts showed the identification of more than 130 molecules dominated by terpenoids (60%) [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Alreshidi

Noumi

Bouslama

et al. 2020

Plants

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The chemical profile of Teucrium polium L. (T. polium) methanolic extract was tested using liquid chromatography coupled with high resolution mass spectrometry (HR-LCMS). Disc diffusion and microdilution assays were used for the antimicrobial activities. Coxsackievirus B-3 (CVB3) and Herpes simplex virus type 2 (HSV-2) were used for the antiviral activities. Chromobacterium violaceum (ATCC 12472 and CV026) and Pseudomonas aeruginosa PAO1 were used as starter strains for the anti-quorum sensing tests. Isoprenoids are the main class of compounds identified, and 13R-hydroxy-9E,11Z-octadecadienoic acid, valtratum, rhoifolin, sericetin diacetate, and dihydrosamidin were the dominant phytoconstituents. The highest mean diameter of growth inhibition zone was recorded for Acinetobacter baumannii (19.33 ± 1.15 mm). The minimal inhibitory concentrations were ranging from 6.25 to 25 mg/mL for bacterial strains, and from 6.25 to 25 mg/mL for Candida species. The 50% cytotoxic concentration on VERO (African Green Monkey Kidney) cell lines was estimated at 209 µg/mL. No antiviral activity was recorded. Additionally, T. polium extract was able to inhibit P. aeruginosa PAO1 motility in a concentration-dependent manner. However, the tested extract was able to inhibit 23.66% of the swarming and 35.25% of swimming capacities of PAO1 at 100 µg/mL. These results highlighted the role of germander as a potent antimicrobial agent that can interfere with the virulence factors controlled by the quorum-sensing systems.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Alreshidi

Noumi

Bouslama

et al. 2020

Plants

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“…Phytochemical studies reported the presence of both volatile and non-volatile compounds. Of the latter, several neo-clerodane diterpenoids were isolated and considered as chemotaxonomic markers of the genus [ 4 , 8 , 9 , 10 ], along with iridoids, sesquiterpenes, triterpenes, abietane diterpenes, flavonoids, and other classes of specialized metabolites [ 11 ]. Much scientific research has already been carried out on essential oils (EOs), since 99 Teucrium taxa have been investigated to date [ 7 ], highlighting the main volatile compounds, which are generally sesquiterpene hydrocarbons.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Essential Oils from Different Taxa Belonging to the Genus Teucrium in Sardinia Island, Italy

Maccioni¹,

Falconieri

Sanna

et al. 2021

Plants

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The genus Teucrium L. (Lamiaceae) is a genus growing in mild climate zones, particularly in the Mediterranean Basin and Central Asia. It is represented by 11 taxa in Sardinia (Italy), living commonly in sunny habitats. In this study, the following eight Sardinian Teucrium taxa were selected, and the essential oils (EOs), obtained by stem distillation, were analyzed by GC–FID and GC–MS: T. capitatum subsp. capitatum, T. chamaedrys subsp. chamaedrys, T. flavum subsp. glaucum, T. marum, T. massiliense, T. scordium subsp. scordioides, T. scorodonia, and T. subspinosum. The comprehensive analyses led to the identification of 87 constituents representing the majority of the volatile compounds. Significant differences, both qualitative and quantitative, were observed between the taxa. Overall, monoterpenes and sesquiterpenes characterized all Teucrium EOs: T. capitatum subsp. capitatum and T. flavum subsp. glaucum revealed the highest content of monoterpene hydrocarbons, while in the other Teucrium taxa sesquiterpene hydrocarbons prevailed. Worthy of note, diterpenes were found only in T. marum and T. subspinosum, whereas T. massiliense was rich in non-terpenic oxygenated compounds. To the best of our knowledge, this is the first comprehensive report on the chemical composition of EOs obtained from Sardinian Teucrium species.

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“…Neoclerodanes and glycosidic iridoids, already isolated by us in T. marum [6], appeared not to be present. In addition to 1, the arabinosyl-verbascoside (2) [13] was detected.…”

Section: Chemical Analysismentioning

confidence: 67%

“…Recently a new clerodane diterpenoid, Teumarine B, was isolated and identified by NMR analysis in the aerial parts of Sardinian T. marum [6]. Glucoside iridoids as harpagide, taucardoside, teucrioside, have also been reported to be present in Teucrium genus [7].…”

Section: Introductionmentioning

confidence: 98%

Endemic species of sardo-corso-balearic area: molecular composition and biological assay of Teucrium

Poli

Serrilli

Scartezzini

et al. 2007

Natural Product Research

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Phytochemical characters ofteucrium marumfrom Sardinia: an endemic plant

Abstract: In this work the iridoidic fraction of Teucrium marum from Sardinia, was examined. A new clerodane, teumarin B, was isolated and identified by 1H- and 13C-NMR spectra analysis. The endemic character of this plant was further confirmed. Teumarin B showed cytotoxic properties.

Cited by 11 publications

References 11 publications

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Characterization of Essential Oils from Different Taxa Belonging to the Genus Teucrium in Sardinia Island, Italy

Endemic species of sardo-corso-balearic area: molecular composition and biological assay of Teucrium

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